Soy phytoestrogens may block estrogen effects
...low-estrogen environment, no evidence of increased proliferation was seen at any level of isoflavone exposure, even...estrogen environment, there was higher breast cell proliferation both when isoflavones weren't in the diet and when they were present in lower doses. However, the ad...New insight into machinery of immune cells' 'tentacles'
...ce deficient in Abi proteins have decreased T cell proliferation in response to activating stimuli, found the researchers. "These findings add important new players in the regulatory pathway downstream of Rac," said Pendergast. "And since immune system activation depends critically on the formation of the synapse,...Scythe balances life and death during development
...ng exactly how Scythe balances apoptosis with cell proliferation could provide significant insights into how organs...receive or failed to respond to signals triggering proliferation or apoptosis. The resulting organs were malformed and unable to function properly, he said. McKinnon...Scientists directly view immune cells interacting to avert autoimmunity
...utoimmune T cells and dendritic cells that lead to proliferation of autoimmune cells and eventually tissue destruction. Co-authors on the paper and collaborators in the research along with Tang, Krummel and Bluestone are Jason Y. Adams, a medical student at UCSF; Mingying Bi, MS, staff research associate; and Bri...Hormone aldosterone is promising target for stroke treatment
... unknown reasons is what causes problems, such as proliferation of the smooth muscle cells that make up the elastic walls of blood vessels. Instead of the middle filling up with plaque as it does in atherosclerosis, the middle, or lumen, of the blood vessel shrinks because the walls thickens. To further set the s...Young cancer researchers honored
...gnaling pathways, and processes that regulate cell proliferation and lead to the formation of tumors, their spread, and their response to treatment. The selection committee is confident that these three young scientists will continue to play key roles in cancer research in the future." Building a better mouse Dr...Jefferson scientists uncover more evidence for protein's role in artery blockage
...xtra GRK5 only in the vascular smooth muscle, cell proliferation continued. They turned to gene therapy and an adenovirus, which enabled them to express GRK5 in any cell. When they injured the left carotid artery in mice, they found cell growth in the artery was dramatically reduced, even four weeks after the inj...Drug not effective in preventing bypass vein clogging
...d pressure and stress on the implanted vein causes proliferation of smooth muscle within the vessel. Edifoligide, an E2F transcription factor inhibitor, showed an ability in earlier studies to block this cellular proliferation. "The results of our Phase III trial showed that the edifoligide was absolutely neutral ...Columbia study suggests benefits of Zyflamend in the early treatment of prostate cancer
... ability, in vitro, to reduce prostate cancer cell proliferation by as much as 78 percent and to induce cancer cell death or apoptosis. The research confirms Zyflamend has COX-1 and COX-2 anti-inflammatory effects, although its anti-cancer affects against prostate cancer were independent of COX-2 inhibition, sup...Contradictory immune responses explain different therapeutic effects in rheumatoid arthritis
...ounts of such growth factors, promoting lymphocyte proliferation and keeping alive the immune cells that drive infl...entiate. Two of these proteins, known as APRIL (A proliferation inducing ligand) and BlyS (B-lymphcyte stimulator), are the targets of new experimental drugs curren...Drug developed at UC Davis may prevent breast cancer, treat post-menopausal vaginal atrophy
...ecreased the growth of the lesions by reducing the proliferation rate of the precancerous cells. The article is available online in advance of its print publication date at www.breast-cancer-research.com. While similar, tamoxifen, raloxifen and ospemifine have variations in chemical structure that give them uniqu...Protein suppresses prostate cancer, enhances effects of vitamin E
... increases the effect of vitamin E in limiting the proliferation of cancer cells, the researchers found. The researchers, led by ShuYuan Yeh, assistant professor of urology and pathology at the University of Rochester Medical Center, are the first to describe the role of a protein known as alpha tocopherol associa...New therapeutic target identified in inherited brain tumor disorder
...wed that fumagillin significantly slowed the rapid proliferation of cultured mouse brain cells that resulted from the loss of Nf1, the gene that causes neurofibromatosis 1. Evaluation of the ability of this class of drugs to control brain tumor growth in small animal models is planned. "This agent and others like...Rapid restoration of immunity in immune-suppressed cancer patients using T-cell vaccines
...ents with multiple myeloma suffer from a malignant proliferation of plasma cells in their bone marrow. The standard treatment for this form of cancer is high-dose chemotherapy and transplantation of one's own blood-producing adult stem cells; however, this aggressive treatment wipes out the mature immune-system ce...Subtypes of ependymomas arise from rare stem cells in the nervous system
...pinal ependymomas included genes that regulate the proliferation and differentiation of normal primitive cells in the corresponding region of the embryonic nervous system. For example, the St. Jude team showed that more than 80 percent of genes expressed at high levels in the supratentorial and spinal ependymomas ...Immune therapy could treat leukemias, autoimmune diseases, transplant rejection
...invading microbes for destruction. Abnormal B cell proliferation causes such leukemias as multiple myeloma and acute lymphoblastic leukemia, and such autoimmune diseases as rheumatoid arthritis and lupus. The researchers, led by Professor and Chair of Immunology Thomas Tedder, Ph.D., reported their findings in th...Fellowship funds major research project on medulloblastoma
...arch for new therapeutic strategies to inhibit the proliferation of a malignant tumour," said A/Prof Glenn Marshall...lising novel small molecules which may inhibit the proliferation of the tumour....Potential 'weak link' between virus and liver cancer discovered
...sion of beta catenin was downregulated, therefore, proliferation of cancer cells will be inhibited. Based on this finding, "we think it may be possible in the near future to develop novel therapeutic approaches for treatment of the aforementioned cancers including development of gene therapy and a small molecule ...Building better therapeutic vaccines for chronic infections
...ic vaccination, or a cytokine that might boost the proliferation or survival of responding cells. Wherry's group a...nderstanding at a fundamental level why the T cell proliferation is poor when a therapeutic vaccine is administered during a state of chronic infection. He is also p......e donor. The capacity of these cells for long-term proliferation is also poor. In contrast, HESCs could provide an unlimited number of specialized cells. According to Lorenz Studer, MD, PhD, Head of the Stem Cell and Tumor Biology Laboratory at MSKCC and senior author of the PLoS Medicine study, the high purity, ...