The odd couple: Unlikely receptor pair key to failed asthma treatments
...rent study, Liggett and colleagues found that PGE2 promotes the pairing or "dimerization" of EP1R with beta2AR, uncoupling b2AR from its signaling cascade, and reducing it's ability to cause muscle relaxation in response to beta2-ARactivating drugs. This may explain why in individuals with severe asthma whose...JCI table of contents: May 1, 2006
...rent study, Liggett and colleagues found that PGE2 promotes the pairing or "dimerization" of EP1R with beta2AR...California, demonstrate that blocking IL-23, which promotes the differentiation of destructive T cells, and its downstream factor IL-17 can significantly suppre...The Lancet Neonatal Series at one year of age has anything changed?
...ing for health-sector reform and strengthening now promotes an emphasis on health for newborn babies as well as mothers and children. However, much still needs to be done to reduce neonatal deaths and accelerate progress towards MDG 4. In their Viewpoint, the authors restate their call for action from last y...World-leading microscope shows more detail than ever
...health, lifestyle and culture. EPSRC also actively promotes public awareness of science and engineering. EPSRC works alongside other Research Councils with responsibility for other areas of research. The Research Councils work collectively on issues of common concern via Research Councils UK. Website address ...Health Partnership Act endorsed By American College of Physicians
...lth insurance coverage for all under a system that promotes continuous quality improvement and the objective assessment of the effectiveness of care in terms of both cost and quality," Kirk emphasized. Under the legislation, she noted, participating states would be measured not only on their ability to incre...Gossip creates friendships, it does not break them
...es about others may have positive consequences; it promotes closeness and friendship. In their study, the authors find that negative attitudes are frequently shared among friends and can even promote friendships among strangers. Gossip is alluring because it establishes in-group/out-group boundaries, boosts...More than just genetics: Lifestyle choices impact GI health
... is produced in the stomach as a response to food, promotes satiety and tends to decrease food intake. Surprisingly, participants who consumed the HGI-HGL breakfast experienced more satiety and fullness compared to those who consumed the other breakfast options. However, this breakfast also caused higher le...Epidemic of unneeded amputations
...l blockages, restores blood flow, and this surgery promotes wound healing, often enabling patients to leave the hospital the next day. CLiRpath has been the subject of rigorous clinical trials, with limb salvage observed in 95 percent of patients surviving to six months(1). The procedure is now available in ...Green tea and the 'Asian Paradox'
...unt of platelet aggregation, regulates lipids, and promotes proliferation and migration of smooth muscle cells, which are all factors in reducing cardiovascular disease, he said. Sumpio said other reports show that EGCG prevents growth of certain tumors. Tea, according to studies, also can improve gastrointe...Drug attacks prostate cancer in mouse model by destroying its blood supply
... PDGF-R stimulates the birth of new blood vessels, promotes cell division and migration, and inhibits a protective form of cell suicide known as apoptosis, all harmful effects in the service of a cancer cell. With imatinib preventing activation of PDGF-R, Fidler said, the endothelial cells died by apoptosis...JCI table of contents, June 8, 2006
...METABOLIC DISEASE A matter of fat: ghrelin hormone promotes storage of energy as fat The hormone ghrelin is p...II HDACs. CaMKII-mediated phosphorylation of HDAC4 promotes the export of HDAC4 out of the cell nucleus, and prevents its entry into the nucleus, thereby liftin...Smoking, eating and thinking: New research on the brain, hormones, and behavior
...s, induces labor, encourages maternal behavior and promotes positive relationship interactions. This work establishes a new role for oxytocin in influencing food tastes and limiting intake of sweets. Whether oxytocin also plays this same role in humans is not yet known, but the investigators hope to extend th...Forget the label. Portion size is all in your mind
...ve a culturally enforced 'consumption norm,' which promotes both the tendency to complete eating a unit and the idea that a single unit is the proper amount to eat." The concept of unit bias helps explain how environmental differences in portions and package sizes impact overall consumption and may provide a ...Cycles of cell death, proliferation key to liver cancer
...in inflammatory cells, such as tissue macrophages, promotes tumor development. In their latest work, the research team studied what precedes inflammation V the injury of hepatocytes caused by toxic chemicals, which sets in motion the inflammation process. Their research showed that the absence of IKK in hepa...ESA donates mosaic of global images taken by Envisat to United Nations
...nited Nations Institute for Training and Research, promotes projects and programmes designed to enable developing countries and local communities in particular to gain access to such technologies and supports humanitarian aid activities. ...Perth researchers to trial bird flu vaccine
...s trial we will increase the dosage to see if that promotes good immunity in a larger proportion of participants, but even with the increase, the total amount of vaccine is still the same as what would be found in conventional flu vaccines." If the vaccine is found to be safe and effective, stocks would the...Proteins spur diabetic mice models to grow blood vessels, nerves
...herapy involves netrins, a family of proteins that promotes nerve development. In a study to be published this...ad shown Netrin-1, a member of the netrins family, promotes blood vessel growth in laboratory cultures. But, until now, it had not been demonstrated that netrin...Highlights from the July 2006 Journal of the American Dietetic Association
...as been suggested that one reason higher education promotes more healthful diets is that better-educated people may get better nutrition information." Most participants in the survey said they rely on doctors and newspapers as their top sources of nutrition information, followed by magazines and television....Rush University Medical Center maintains Magnet status for quality nursing
...ghly skilled nurses and foster an environment that promotes quality patient care. In all, a little more than 200 hospitals out of approximately 5,000 hospitals nationwide have been awarded Magnet designation since the program was formally established in 1993. "Everyday our nursing staff demonstrates excelle...Identifying medical proxy should be part of routine medical care
... patient's relationship with his/her physician and promotes continuity of care. "Advance care planning is not about documents -- it is about persons and their relationships," Lipkin said. ...