Tag: "protease" at medical news
Asymptomatic HIV-infected newborns may benefit from early drug treatment, Stanford study shows
... of a special type of antiretroviral drug called a protease
inhibitor. They followed the children for the first three years of life, tracking at what age they developed AIDS and the rate of survival through their third birthday. As might be expected, infants born later in the study period were more likely to ...
Lag-time often occurs before new treatments for pediatric HIV infection are used
...day's complex regimens of NRTI in combination with protease
inhibitors (PIs) and/or nonnucleoside reverse tran...st frequently through 1997. In 1998, 2 years after protease
inhibitors were approved for adult HIV infection and at the time pediatric guidelines were issued, r...
UIC developing drug for SARS
...tute of Allergy and Infectious Diseases to develop protease
inhibitors that would block key enzymes in the SAR... study's principal investigator. "By administering protease
inhibitors early, when feverish symptoms have started, the drugs could reduce the viral load and ame...
New HIV guidelines support use of FUZEON + active boosted PI for treatment-experienced patients
...s support the use of FUZEON with an active boosted protease
inhibitor (PI) for the management of treatment-exp...able, when combined with one of the latest boosted protease
inhibitors (PI) such as lopinavir, tipranavir or TMC 114. The guidelines recommend the treatment goa...
Columbia study shows how doctors may manage blood glucose levels during heart surgery
...ed the first human study to show that aprotinin, a protease
inhibitor, was associated with lower blood glucose levels during coronary artery bypass graft (CABG) surgery. The research presented today at the American Society of Anesthesiologists 2005 Annual Meeting in Atlanta, Ga., showed that CABG patients rec...
TPV EU approval provides new HIV active drug to be combined with FUZEON
...linical trials combining FUZEON with other boosted protease
inhibitors, including lopinavir/r and TMC 114/r. The use of FUZEON with tipranavir for the management of treatment-experienced patients was supported by recently updated treatment guidelines by the Department of Health and Human Services in the US, w...
Cancer cell communication exposed
...tumour cells. The "switch" involves a cell-surface protease
called ADAM 10 that regulates the signals that promote tumour growth and motility of cancer cells. Understanding the structure of the ADAM 10 molecule provides the basis for developing pharmaceutical drugs to inhibit tumour growth and metastasis - th...
Investigational boosted protease inhibitor, TMC114, works better with FUZEON
...UZEON (enfuvirtide) to the investigational boosted protease
inhibitor (PI), TMC114/r, more than doubles the proportion of patients reaching undetectable levels of the virus. This latest study provides further evidence that FUZEON now makes undetectable viral loads more achievable for patients failing on their...
Study sets new gold standard for initial antiretroviral treatment of HIV infection
...anscriptase inhibitors, such as efavirenz, or with protease
inhibitors, which were not used in this study....
Ethnic differences in response to HIV medicines
...etic variants of lipoproteins apoC-III/apoA-I, and protease
inhibitors (a class of drugs used against HIV) aff...ated with less dyslipidemia in patients exposed to protease
inhibitor-containing highly active antiretroviral therapy. HIV-1 infection has become a chronic, man...
Race/ethnicity predict lipids, heart-disease risk in HIV-1 patients on protease inhibitors
...a particular class of anti-AIDS medicines known as protease
inhibitors. The study, published in the January i..., found in the blood of HIV-1 infected patients on protease
inhibitors as part of combination antiretroviral therapy. These blood fats, known as lipids, put peo...
The smoking gun: Elastin fragments drive emphysema
...e studies suggest that the degradation products of protease
activity, in addition to the proteases themselves, may be promising targets for emphysema therapy....
Update on tuberculosis -- 2005
...ighly active antiretroviral agents, especially HIV protease
inhibitors," said Dr. Yew. He noted that an alternate member of the rifamycin class called rifabutin has much less effect against the antiretroviral agents. "Thus, rifabutin-based therapy appears to be a better choice for HIV tuberculosis," he added....
Bone resorption cells offer drug targets for osteoporosis, rheumatoid arthritis, and more
...years, scientists have documented that some of the protease
inhibitor drugs that have had such a dramatic effe...s on the osteoclasts, suggesting that changing the protease
inhibitor being given might diminish bone loss, or that patients on protease
inhibitor drugs may nee...
Understanding cell death may bring new life to kidney treatment
...the kidney fails, he says. One goal is finding the protease
that cleaves Bid he doesn't think it's Bax and following the ensuing cascade to better understand the process so it can be manipulated to stop needless cell death or, in the case of cancer, enhance self-destruction. In related research, Dr. Dong's ...
Novel therapy combinations gain ground in treating hepatitis
...etter patient outcomes. A new oral peptidomimetic protease
inhibitor, VX-950, has previously shown substantial anti-viral effects in combination with the frequently used hepatitis therapy pegylated interferon (pegIFN). In this study, researchers evaluated the safety and antiviral response of VX-950 in combi...
JCI table of contents, June 8, 2006
...pment of resistance to chemotherapy. TITLE: Serine protease
HtrA1 modulates chemotherapy-induced cytotoxicity AUTHOR CONTACT: Elizabeth Zimmermann Communications, Mayo Clinic Cancer Center, Rochester, Minnesota, USA. Phone: (507) 284-5005; E-mail: email@example.com . View the PDF of this article at: http...
World's first approval of new HIV drug TMC114 provides potent new treatment option with FUZEON
...e US approval of TMC114 (darunavir), a new boosted protease
inhibitor (PI), provides the opportunity to build a potent new treatment combination with the fusion inhibitor FUZEON (enfuvirtide) that can successfully combat the HIV virus in treatment resistant patients. Data have shown that up to two-thirds of p...
W.M. Keck Foundation announces 2006 class of Distinguished Young Scholars in Medical Research
...s, such as those associated with HIV infection and protease
inhibitor drug treatment. Russell DeBose-Boyd, Ph.D., Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas - Dr. DeBose-Boyd studies an enzyme, HMG CoA reductase, that controls the production of cholesterol...
Research leads to first treatment for drug-resistant HIV
...ne of the most common treatments existing today, a protease
inhibitor. Protease is an enzyme necessary for HIV to reproduce properly. A protease
inhibitor binds to protease, making it unusable by the virus. Without the use of protease, HIV is in...