Tony Hunter receives Robert. J. and Claire Pasarow Award for Cancer Research
..., as researchers found ways to inhibit the special proteins called tyrosine kinases that are responsible for t... is a common way in which the body turns on or off proteins such as enzymes. Thus, phosphorylation of proteins in cells, which is often triggered by external st...MUHC-led international team identifies gene responsible for blindness in infants and children
... the retina. Both the CEP290 and LCA5 genes encode proteins with vital functions in the cilium of the photoreceptors, transporting visual proteins to the compartment where vision occurs. When these genes are mutated, which occurs in about 25 to 30...Vorinostat shows anti-cancer activity in recurrent gliomas
...ls. By inhibiting the deacetylation of histones -- proteins that help organize the structure of DNA -- vorinos...ters the expression of several important genes and proteins resulting in tumor cell death and stopping tumor growth. Dr. Galanis says that study findings indi...GSK's Pazopanib shows positive results in patients with advanced renal cell carcinoma
...rowth factor receptor (PDGFR) and c-kit, important proteins in the angiogenic process. Angiogenesis, which is the growth of new blood vessels in the body, plays a critical role in the growth and spread of tumors. , Renal cell carcinoma study (Abstract 5031) DATA EMBARGOED UNTIL SATURDAY JUNE 2, 8A...GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer
...rowth factor receptor (PDGFR) and c-kit, important proteins in the angiogenic process. Angiogenesis, which is the growth of new blood vessels in the body, plays a critical role in the growth and spread of tumors. Renal cell carcinoma study (Abstract 5031) DATA EMBARGOED UNTIL SATURDAY JUNE 2, 8AM...Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
...this is one of the key mechanisms involved in this proteins anti-inflammatory effect on the vascular system," he notes. "That suggests thinking about either activating the receptors of the target of this protein or administering the fragment." Adiponectin is the most abundant protein found in the bloodstrea...Scripps Research awarded $17 million for adult stem cell use to treat eye diseases
...ually due to the abnormal deposition of angiogenic proteins and lipids as seen in ARMD). But, unlike in the heart or brain, where the extra blood vessels can have a benefit, in the eye the new vessels wreak havoc, leaking fluid and blood and leading to vision loss. Current treatments for neovascular eye disea...Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
...called urea cycle disorders. The condition affects proteins in the liver that are necessary to process the by-... the body as urine. Mutations in several different proteins can short-circuit the urea cycle, which occurs in the liver, but the result is the same: escalating ...Ground breaking research to end in tears
... of molecules on tears- the 'tear film' - we found proteins previously thought to be confinedto the aqueous po...iate Professor Millar revealed, for the firsttime, proteins at the surface also played an unexpected role slowingdown the break-up rate of tears. "Proteins on...Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu
...rlying genetic abnormality: Information for making proteins is stored in DNA as groups of three nucleotides (codons), each specifying a different amino acid (the building blocks of proteins). In triplet repeat diseases, patients inherit a mutant gene containing abnormally long stretches of repeated codons. In...Possible new breast cancer gene
...ene sequence. More specifically, modification of proteins in the cell nucleus by another protein called ubi...ip with BRCA1. Many of the genes that encode these proteins are also altered in familial breast cancer. "Thus Rap80, by interacting with a BRCA1 region that ...Stem cells provide clues to cancer spread
...e epithelial-mesenchymal transition. They lose the proteins that cells use to bind to each other and have other protein alterations that are characteristic of spreading cancer cells. "Since ES cells can be grown in the laboratory where they keep the characteristics of the cells in the early embryo they can ...Drug eluting nanostructured coatings enable targeted drug therapy for orthopedic patients
...ocompatible metal oxides that can hold therapeutic proteins or drugs and deliver these agents in a highly-controlled manner. The fabrication strategies developed by the authors is flexible in terms of controlling the diameter and length scales of the tubes. By changing these physical parameters of nanotube...JCI table of contents -- May 17, 2007
...ls can be enhanced. During vessel development, 2 proteins EphB4 and ephrin-B2 are expressed in the endothelium that lines blood vessels. Tobelem et al. showed that EphB4 activation with an ephrin-B2-Fc chimeric protein enhanced EPC activation and new vessel growth in the ischemic hind limbs of mice. This ...UC Irvine researchers reveal first images of brain changes associated with memory
...ained with one antibody that attaches to activated proteins involved with LTP and a second one that labels synapses. Newly developed microscopic methods were used to visualize and measure synapses that had both antibodies attached. In addition to revealing new information about the formation of memory in t...Violent sleep disorder linked to a form of dementia
...eurologist and lead author of the study. Synuclein proteins are associated with synapses in the brain, and clumps of abnormal alpha-synuclein protein are present in some forms of dementia. "The problem does not seem to be present in the synuclein gene itself, but its something that happens to the protein foll...Aspirin use during pregnancy could reduce risk of pre-eclampsia
...gh blood pressure and proteinuria (excess of serum proteins in the urine). Dr Lisa Askie, University of Sydney, Australia, with funding from the Australian National Health and Medical Research Council, along with colleagues from Australia and the UK, formed the Perinatal Antiplatelet Review of International...Glucosamine-like supplement inhibits multiple sclerosis, type 1 diabetes
...and autoimmune activitiy of T-cells. Virtually all proteins on the surface of cells, including T-cells, are modified with complex sugars of variable lengths and composition. Recent studies have shown that changes in these sugars are often associated with T-cell hyperactivity and autoimmune disease. In mous...Can an omega-3 fatty acid slow the progression of Alzheimer's disease?
...l markers of Alzheimers, such as brain atrophy and proteins in blood and spinal fluid....Discovery of cellular processes which regulate heart's energy supply
...al role in coordinating the expression of a set of proteins that the heart requires to produce the energy it needs to pump effectively. "Nuclear receptors receive signals from different parts of the body," explains Dr. Gigure's. "These signals "tell" the cell what action to take by controlling which geneti...