Cause of gender differences in blood pressure, kidney damage under study
...eral. In high blood pressure, free radicals damage proteins critical to blood vessels and the kidneys. The body has natural mechanisms for keeping free radicals in check, including endogenous antioxidants. "But if you get increases, it can overwhelm the natural ability of the body to take care of it," she s...Green tea extract protects against brain damage in new mouse model of HIV-related dementia
... green tea greatly diminished the neurotoxicity of proteins secreted by the human immunodeficiency virus, sugg... effects of HIV upon the brain. The virus secretes proteins known as Tat and gp120, which have direct toxic effects on the neurons. The proteins also have indi...'Wrapping' Gleevec fights drug-resistant cancer
...ffects were tested against more than 250 catalytic proteins called kinases, which are in the same class of proteins as KIT, to make sure the drug would not have unintended consequences. Finally, a range of in vitro t...Iyengar yoga can promote well-being in women breast cancer survivors
...ction of genes in immune cells can be regulated by proteins called transcription factors. Transcription factor nuclear factor-kappa B (NF-?B) is linked to immune cell activation and to the stress response. The study, entitled Down-regulated lymphocyte NF-?B activation in breast cancer survivors following y...Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level
...is and a sophisticated computer algorithm to study proteins known to be associated with human diseases. When t...brils. "Structural analysis of micro-crystals of proteins is an example of how basic research can have a profound impact on our understanding of health, biote...Largest ever grant for University of Copenhagenhagen
...most advanced laboratory facilities to study human proteins and their significance for health and disease. "...eptional donation, we can boost research into what proteins look like and how they behave and interact in cells and tissues in healthy and sick people. This ins...Green tea compound suppresses factors causing cartilage, bone destruction in arthritis
...GCG markedly blocked IL-1's ability to produce the proteins and enzymes that infiltrate the joints of persons with rheumatoid arthritis causing cartilage degradation. The scientists decided to extend their study to see if the green tea compound also has the capability to block the activity of two other p...Green tea compound may be a therapy for people with rheumatoid arthritis
...arkedly blocked the ability of IL-1 to produce the proteins and enzymes that infiltrate the joints of persons with rheumatoid arthritis and cause cartilage degradation. The laboratory now is focused on the inhibitory role of EGCG in gene expression. The scientists plan to test EGCG in animal models of rheu...$7.5 million NIH grant to Yale for Autism Center of Excellence
...th project focuses on a family of genes and linked proteins found to be associated with forms of autism. Autism is a complex brain disorder that inhibits a persons ability to communicate and develop social relationships, and it is often accompanied by extreme behavioral challenges. Autism affects about two...Speeding 'fingertip' discovery -- 20 years of protein info in 1 place
...antage of a new technique that reads the makeup of proteins to identify nearly all chemical changes nature makes by adding phosphate to proteins manufactured in human cells. The Hopkins team then added its list of these so-called phosphorylat...Head and neck cancer vaccine targets proteins to create immune response
... are assisted by helper T cells that secrete small proteins called cytokines to regulate or "help" the immune response. Given that the proof of principle for the vaccine has been determined, a phase I clinical trial of the vaccine has begun at the University of Pittsburgh Cancer Institute to assess its saf...Research could lead to treatment for Alzheimer's disease
...ue formation is made up of fibrous clumps of toxic proteins that cause the devastating symptoms of Alzheimer's disease, said Ghosh, who has a dual appointment in the chemistry and medicinal chemistry and molecular pharmacology departments. "Interdisciplinary research and the tools available today allowed us...Researchers discover gene crucial for nerve cell insulation
...em. The overproduction or underproduction of the proteins PMP22 and MPZ account for the majority of inherited peripheral neuropathies, Dr. Svaren said. Ultimately, the sequence of activating genes "switches on" the Schwann cell, which wraps the nerve axon, the arm-like projection that conveys nerve impuls...Diet and lifestyle -- In the cancer fight, eating well is the best revenge
... major isoflavone in soy, reduce production of two proteins whose chemotactic attraction to each other is nece...ein, levels of CXCR4 and CXCL12 messenger RNAs and proteins decrease in a dose-dependent manner, compared to untreated cells, according to Hsu. To assess whe...Experimental flu vaccine appears promising in early tests
... "The use of recombinant DNA techniques to express proteins in cell culture has been a successful approach for generation of highly effective vaccines for the prevention of hepatitis B virus and human papillomavirus. Among the available expression technologies, recombinant baculovirus is especially well suite...Weak immune response critical to disease that causes most infant hospitalizations
...nfected and influenza-infected babies, looking for proteins and cytokines immune signaling molecules made by T cells, and we saw no evidence that T cells had been activated in the RSV babies," said UTMB professor Roberto Garofalo, a senior author of a paper on the research scheduled to appear in the April 1...A sweet step toward new cancer therapies
...to assemblies of sugars called glycans attached to proteins on cancer cell surfaces as accomplices in the grow... molecules---to analyze proteins. In this process, proteins are introduced into the mass spectrometer and fragmented by heating until the weakest bonds break. "...Blocking immune cell action increases Alzheimer's-associated protein deposits
...the brain. Since CCR2 is known to bind chemokines, proteins that attract immune cells and are elevated in brains affected by Alzheimer's, the receptor could be important for the movement of microglia to the site of amyloid-beta deposits. To test that possibility, the investigators used a mouse model of Alzhe...... breaking down the communication between cells and proteins involved in forming clots. TRA, which is manufactured by Schering-Plough Corporation, was given in addition to established anti-clotting drugs to 1,030 patients undergoing cardiac catheterization and related intervention at 77 sites in six countries ...