Use of oral fluids to diagnose and treat disease
... to demonstrate how these fluids contribute unique proteins to oral fluid, and to establish what proteins are found in healthy, "normal" oral fluid. In the future, this information will be compared with tha...Inhibiting blood to save the brain
...ssue of Journal of Experimental Medicine. "Blood proteins have been neglected as a therapeutic target, but this research shows that a blood clotting factor is an important player in MS." MS is an inflammatory disease that affects the central nervous system, causing symptoms such as loss of balance and ...Simmer to receive research in Biological Mineralization Award
... formation. Early in his career, in studies on the proteins guiding tooth enamel development and maturation, h...ation of dentin sialophosphoprotein (DSPP)-derived proteins (DSP, DGP, and DPP) have pushed our understanding of these important proteins to new levels. The I...Researchers hot on the trail of brain cell degeneration
...the study, the Rho protein, belongs to a family of proteins able to influence signals that had been linked to cell degeneration. The two teams' analysis demonstrated that over-stimulation causes activation of Rho as well as cell destruction signals. Blocking Rho activity by genetic modification keeps the prot...Therapeutic unshackles p53 and causes tumor regression
...action between the KSHV protein LANA and the human proteins p53 and MDM2, releasing p53 to mediate apoptosis. As treatment with Nutlin-3a induced substantial tumor regression in mice with established human PEL, reactivation of p53 using Nutlin-3a might provide a viable therapeutic for the treatment of individ...Infection detectives use disease 'fingerprints' to track common infections in children
...he activation of very specific genes that code for proteins called receptors in leukocytes, the white blood cells that help the body fight infections. Researchers surmised that if they looked at the leukocytes, they could detect the specific pattern of receptors similar to a disease "fingerprint" and be abl...Strenuous physical activity associated with lower breast cancer risk
...rmone receptor type, or which hormones can bind to proteins on the surface of the tumor. Strenuous activity appeared to be associated with a lower risk of estrogen-receptornegative but not estrogen-receptorpositive breast cancers. "In summary, these results provide additional evidence supporting a protecti...U of M discovers protein linked to elevated BMI in people of American Indian and Mexican ancestry
...important discoveries related to blood coagulation proteins involved in bleeding disorders such as hemophilia ... and thrombosis. The university has licensed these proteins to three pharmaceutical companies who are developing them as therapeutic agents. Nelsestuen is recog...CRP liver protein induces hypertension, UT Southwestern researchers have found
...l constriction. This was due to alterations in key proteins in the vascular wall that are involved with angiot... as made a connection between nitric oxide and the proteins responsible for angiotensin II activity. "Whether these same processes are operative in humans is ...Scientists create dual-modality microbeads to improve identification of disease biomarkers
...ads are mixed in a liquid such as urine. Viruses, proteins or other biomarkers are captured on the bead surfa... virus in the liquid sample based on the number of proteins or viruses attached to the surface of the beads. Tushar Sathe, a graduate student in the Wallace ...Physicists set 'speed limit' for future superconducting magnet
...use even more powerful MR technology to study DNA, proteins and other complex molecules. About a dozen labs around the country take advantage of the highest magnetic field now in use -- 21.1 Tesla, which produces a magnetic field 10 times larger than your average hospital machine. Increasing the field of the ...Prematurity more accurately predicted by advances in proteomic technology
Abnormal proteins in amniotic fluid that signal a higher risk of del... MR scoring relies on identification of a group of proteins that serve as biomarkers characteristic to women who will deliver preterm. A normal MR score is 0...ACS News Service Weekly PressPac -- January 31, 2007
...aging never-before-seen objects such as individual proteins traveling along the microtubules that make up a cell's skeleton and act as superhighways for molecular transport. Zhang and colleagues point out that existing superlenses, including one developed by his group in 2005, can form an image at the near ...NHLBI awards 12 Women's Health Initiative contracts
... association of adipokines (physiologically active proteins from body fat cells) with cancer and stroke risk, and the role of these proteins in the association between obesity and the risk of cancer and stroke. "Physical Activity, Obesity...New research brings initial find of Alois Alzheimer to fore once again
The two dominant proteins that determine how much blood flows through the bo...gnized early last century. The research, putting proteins often linked to heart disease front and center in a brain disease whose causes remain a mystery, har...Transdermal vaccine effective in treating Alzheimer's disease in mouse model
... immune cells aggressively attacked the body's own proteins produced by the vaccine. The USF researchers targeted the skin as the route of vaccine delivery in mice bred to develop age-related brain degeneration mimicking Alzheimer's. They found that transdermal immunization with Ab does not appear to trigg...Einstein's tea leaves inspire new blood separation technique
...g). Separating blood plasma from red blood cells, proteins and other microscopic particles is an essential step in many common medical tests, including those for cholesterol levels, drugs in athletes, blood types in donors and glucose levels in diabetics. Current testing requires samples to be taken in a doc...Exploring the molecular origin of blood clot flexibility
...y that alpha-helical structures in some blood-cell proteins unfold at low levels of mechanical force. But "it wasn't known before that the coiled coil region of the fibrinogen molecule would be the part to unfold under the stress induced by the atomic force microscope," notes Brown. Once the origins of the ...JRRD releases single-topic issue focused on vision rehabilitation
...s to grow in cell culture on surfaces that contain proteins believed to foster RPE migration and proliferation. We found that old as well as young RPE cells can grow in cell culture on surfaces that contain appropriate extracellular matrix ligands. These results will guide us in developing techniques to provi...Researchers warn milk eliminates cardiovascular health benefits of tea
...tudy showed that the culprit in milk is a group of proteins called caseins, which they found interacted with t...hem to tea on its own and tea with individual milk proteins added, and got the same result." Milk contains a number of different proteins: by testing each one ...