Chronic alcohol exposure can affect brain protein expression
...ve identified several novel central nervous system proteins that are affected by chronic alcohol exposure. They also confirmed the involvement of additional proteins previously suggested as targets of alcohol toxicity, and observed abnormal behavior in the fish resu...Previously approved drugs may be helpful in fatal pediatric disorder
...test a synthetic compound that activated genes for proteins that break down cholesterol and remove it from cells. At the same time, Synthia H. Mellon, Ph.D., of the University of California-San Francisco, was treating the same mouse line with a naturally occurring nervous system steroid similar to the cholest...Researchers identify antibiotic protein that defends the intestine against microbial invaders
...ter surfaces," Dr. Hooper said. "Once bound, these proteins quickly destroy their bacterial targets. They're killer proteins with a sweet tooth." The protein, called RegIIIgamma in mice and HIP/PAP in humans, belongs to a p...Columbia researchers restore memory lost in mice with Alzheimer's
...le called CREB, which is inhibited by amyloid beta proteins in people with Alzheimer's. By increasing Uch-L1 l...o create new memories. "Because the amyloid beta proteins that cause Alzheimer's may play a normal, important physiological role in the body, we can't destroy...Scientists stop autoimmune disease without shutting off immune system
...protection because their immune system attacks the proteins that hold skin cells together. They develop severe blisters and raw sores as the top layer of their skin falls apart, leaving them extremely vulnerable to infection. The development of drugs that completely suppress the immune system offered a life...Scripps research team reverses Friedreich's ataxia defect in cell culture
...own as the "histone code theory." Histones are proteins that are the chief constituent of the nucleosomes ...plets cause an unusual DNA structure that attracts proteins such as histone deacetylases (HDACs), removing critical acetyl groups from the histones, packaging t...3-D forms link antibiotic resistance and brain disease
...is indispensable to all forms of life. Enzymes are proteins that speed up biochemical reactions. CoA plays a pivotal role in the cells' ability to extract energy from fatty acids and carbohydrates; bacteria need CoA to make their cell walls. The job of pantothenate kinase is to grab a molecule of pantothenic ...Boosting key protein in brain could improve seizure treatment, Stanford study finds
...ompound in the brain. Neuropeptides are very small proteins that often help transmit signals between neurons, the specialized cells in the brain that generate and transmit thought. "This finding really emphasizes that our brains have the inherent capacity to stop seizures," said John Huguenard, PhD, associa...Study finds cardiac toxicity rates high with herceptin use
... is a monoclonal antibody that latches on to these proteins and inhibits tumor growth. Other clinical trials t...otes that some animal studies have shown that HER2 proteins play an important role in the development of cardiac cells, so the treatment may affect their normal...Clinical trial evaluates first-line approaches for treating HIV
...wn as protease inhibitors blocks the maturation of proteins that HIV needs to assemble itself into an infectious virus. ...Arthritis drug helps debilitating inflammatory disease
...cryopyrin, which belongs to a group of interacting proteins involved in regulating inflammation and programmed cell death, which plays a crucial role in ridding the body of cells that are no longer needed. The mutations, scientists have found, lead to an imbalance of a cytokine, or chemical messenger, called ...Zebrafish show advantages in assessing human cancer cell-induced angiogenesis in vivo
...ls can be delivered directly in the fish water and proteins can be injected, assessment of cytotoxic, apoptotic or anti-angiogenic effects of potential drug candidates, singly or in combination, is straightforward. "Our research demonstrates that zebrafish provide important advantages as a research model, w...Nicotine found to protect against Parkinson's-like brain damage
...e may stimulate the release of naturally occurring proteins called growth factors that play a key role in nerve cell growth and repair. "It is also possible that the nicotine may activate the immune system to protect the cells from MPTP-induced damage," said Quik. According to Quik, Parkinson's disease sympto...New bird flu drug promises to beat the problem of resistance
...ted with two different types of enzymes. These are proteins which carry out specific jobs for the virus. The... infect other cells. (Differences in the H and N proteins allow scientists to distinguish between the different types of influenza virus. For instance, the cu...Key event in cell death occurs as single, quick event
...ng investigators to observe the release of certain proteins from pores in the membranes of mitochondria. These...n the membrane surrounding them holds a variety of proteins that are released during apoptosis. Results of the study indicate the formation of pores in the mit...Keep the baby, toss the bathwater: How kidneys retain proteins, discard waste
...d debate about how the kidney keeps valuable blood proteins from harmfully slipping into the urine, a serious ... (GBM), normally plays a key role in keeping blood proteins out of the urine. The finding, reported in the August issue of the Journal of Clinical Investigati...Pigeons provide clue to solving common problem in heart patients
... Heart Association. Genes "express," or produce, proteins that are used in building tissue. The process begins with "transcription," or the copying of a gene's DNA sequence. It is not known which genes might control the pigeons' heart vessel tissue-building process, so Wagner's group focused on "transcrip...MIT researchers watch brain in action
...researchers to monitor over time the expression of proteins in the brains of live mice. The study exploited ...o 1 millimeter deep, enough for researchers to see proteins expressed within individual neurons within the brain. They then created a mouse model in which a ...Cerebrospinal fluid used to deliver therapeutics for Lou Gehrig's disease to brain
...rig's disease, in rats. The aggregation of toxic proteins in the central nervous system (CNS) underlies many...e, and ALS. Several strategies for removing excess proteins from the brain have been tried, but few have been successful due to the impermeability of the protec...Promising therapy for ALS delivers antisense drug directly to nervous system
...is. Neurotoxicity from an accumulation of mutant proteins is believed to be at the root of many neurodegenerative diseases. ALS can be caused by a mutation in a protein called SOD1, and the antisense drug effectively silences the gene that codes for this mutant protein found in the cells of patients with ...