Tag: "receptor" at medical news

Regulator of lipid metabolism ensures high quality breast milk

... Mouse mammary glands deficient in PPAR, a nuclear receptor that regulates the storage of fat, produce toxic milk that causes inflammation and baldness in suckling pups, report scientists at the Salk Institute for Biological Studies. We were quite surprised by the unexpected quality control mechanism that ...

New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi

...t Minetta Liu, MD, it is expected that all hormone receptor positive metastatic breast cancers will eventually... found that XBP1 is co-expressed with the estrogen receptor in breast tumor cells. This may mean that the effects of XBP1 over-expression occur when the protein...

Penn study finds pro-death proteins required to regulate healthy immune function

... Specifically, the team found that when the T-cell receptor was stimulated on mutant cells lacking both proteins, proliferation was severely reduced relative to normal cells. Closer investigation showed that the amount and rate of calcium release from intracellular stores was altered in the mutant cells. T...

NIH scientists target future pandemic strains of H5N1 avian influenza

...ne portion of the H5 protein--a portion called the receptor binding domain. They showed that as few as two mutations to this receptor binding domain could enhance the ability of H5N1 to recognize human cells. Additional mutations w...

ACC/AHA release revised UA/NSTEMI guidelines

... protect the muscle--- and prescribing aldosterone receptor blockade, a new drug category that wasnt available previously for people with heart failure, said Wenger. High-dose antioxidant vitamin supplements such as beta carotene, vitamins E and C and folic acid for secondary prevention are no longer recomme...

Hormone therapy offers new hope for ovarian cancer patients

...earch UK and involved 44 women with high oestrogen receptor (ER) levels, whose cancer had relapsed after surgery and chemotherapy. Scientists used a blood-borne tumour marker, CA-125, to track the progress of tumours during hormone treatment. They discovered that one quarter of the women showed no tumour g...

How to lose weight and not go hungry: HU researcher develops drug that mimics feeling of 'fullness'

...is naturally excreted during eating and binds to a receptor in the brain called MC4R. When this communication ...ce in the blood, it could make its way to the MC4R receptor and close the circuit to send out the full signal. The result is that a person seriously wishing ...

UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells

... attaching a ligand against a cancer-cell-specific receptor can make the nanoparticles recognizable by cancer cells. A critical obstacle and challenge for cancer therapy is the limited availability of effective biocompatible delivery systems. Since many effective anticancer agents have poor water solubility...

Low-carb diets' effects linked to rise in newly identified 'starvation hormone'

...as a mediator of peroxisome proliferator-activated receptor " (PPAR"). Scientists have known that PPAR""controls fats use as an energy source during starvation. In addition, some drugs that lower "bad" cholesterol work by targeting PPAR"" Kliewers group showed that FGF21 is induced directly by PPAR" in live...

Extra pay does not improve hospital performance

...-converting enzyme (ACE) inhibitors or angiotensin receptor blockers for weakened left pumping chambers. These measures were selected because clinical trials have proven that their use improves the outcomes for heart attack patients. The monetary incentive for the CMS study was relatively small. Over a two-...

USC researchers show that molecular markers predict tumor recurrence

...r endothelial growth factor protein (VEGF) and its receptor VEGFR-2 as one of the most important activators of tumor angiogenesis. Patients with polymorphisms in the EGFR and VEGFR genes had a higher likelihood of tumor recurrence, the study shows. The results also show that patients with stage II colorecta...

Benefits of trastuzumab are lasting, reducing both HER2 + breast cancer deaths and recurrence

...R2 + cancer that was further sub-typed as estrogen receptor (ER)-negative. So far, 118 patients in the trastuzumab treatment group have developed progressive disease, a second primary cancer or contralateral breast cancer (cancer in the other breast), compared with 243 patients in the chemotherapy group. I...

Hot flashes may be welcome sign in women with breast cancer, study says

... a stronger predictor of outcome than age, hormone receptor status or even how advanced the breast cancer was at diagnosis. The study results were presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago today. "Hot flashes are a very common and disruptive problem in breast...

AMPAKINE compounds a new potential treatment for respiratory depression

...ced respiratory depression is to administer opiate receptor antagonists, drugs that block the effectiveness of...INE compounds act on the most common excitatory receptor in the brain, the AMPA "Glutamate type receptor," which has been shown in rodent models to boost the...

Study finds difference in survival rates among white and black women with advanced breast cancer

...Adjustment factors included: patient age; estrogen receptor status; and tumor grade. Patients were divided into three subgroups: those diagnosed from1988 to 1993; from 1994 to 1998; and from 1999 to 2003. Overall, the median age of the women was 62 years old; median breast cancer-specific survival was 20 mo...

GSK's Pazopanib shows positive results in patients with advanced renal cell carcinoma

...bitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit, important proteins in the angiogenic process. Angiogenesis, which is the growth ...

GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer

...bitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit, important proteins in the angiogenic process. Angiogenesis, which is the growth ...

MRI detects cancers missed by mammography in breast cancer patients

...a common type of tumor, one classified as estrogen receptor (ER)-positive, says the contralateral breast studys lead investigator, oncology resident Johnny Bernard Jr., M.D., who works with Dr. Vallow. This result mirrors findings of a 969-patient study reported in April 2007 in the New England Journal of Med...

Detecting cold, feeling pain: Study reveals why menthol feels fresh

Scientists have identified the receptor in cells of the peripheral nervous system that is ...in this case that can cause pain. As such, the receptor known as menthol receptor TRPM8 -- provides a target for studying acute and chronic pain, as can re...

Scripps Research awarded $17 million for adult stem cell use to treat eye diseases

...scular endothelial protease and protease activated receptor signaling; from the Nemerow and Siuzdak groups in molecular tools for the modification and analysis of progenitor cells; and from the Balch lab on the cell biology of retinal pigmented epithelial cells. In addition, a member of the Friedlander lab, S...

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(Date:10/14/2014)... – October 14, 2014 – Scientists from The Scripps ... the National Institutes of Health (NIH) to lead an ... hemorrhagic fever disease in Africa. The study aims to ... some patients die, while others survive the inflection. ... the basic mechanism of how Lassa fever virus causes ...
(Date:10/14/2014)... international team of researchers, led by the Chinese Academy ... Nature Genetics a brief genomic history of ... the tomato plant. , The C.M. Rick Tomato Genetics ... in this study by providing seed of both cultivated ... which builds on the first tomato genome sequence completed ...
(Date:10/14/2014)... – Over the past decades, we have seen numerous ... the needs of infants for social contact and stimulation ... thrive. , Infancy and childhood are critical ... A generation of research suggests that enriched environments, full ... cognitive function. In contrast, deprivation and stress may compromise ...
Breaking Biology News(10 mins):Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2Institutional rearing may increase risk attention-deficit disorder 2
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