Tag: "receptor" at medical news

Breastfeeding reduces risk of breast cancer for women who delay childbirth

... protection against both estrogen and progesterone receptor positive and negative tumors." While having a fi...rst birth, their breastfeeding history and hormone receptor status. Previous results from the Women's CARE Study have shown that early age at first pregnancy...

Diet and lifestyle -- In the cancer fight, eating well is the best revenge

...ls express very high levels of the CXCR4 chemokine receptor on the surface of their cells, and the organs to which these cancers metastasize secrete high levels of the CXCL12 chemokine ligand. This attraction stimulates the invasive properties of cancer cells and acts like a homing device, drawing the cancer...

Treatment of in-hospital cardiac patients is focus of Jefferson University presentations

...condition. They included ACE-inhibitor/angiotensin receptor blockers, beta blockers, aldosterone antagonists or loop diuretics. By analyzing a number of measures, including hemoglobin concentration (the component of red blood cells that carry oxygen) which determines the severity of the anemia, the researcher...

Blocking immune cell action increases Alzheimer's-associated protein deposits

...research team focused on a molecule called CCR2, a receptor on the surface of microglia and other immune cells...re elevated in brains affected by Alzheimer's, the receptor could be important for the movement of microglia to the site of amyloid-beta deposits. To test that...

EVEREST data on use of tolvaptan published in JAMA and featured at ACC

...igational oral medication tolvaptan, a vasopressin receptor antagonist, was associated with improvements in si...tential to be the first available oral vasopressin receptor antagonist. Short-Term Studies: Pre-Specified Secondary Endpoints In the two short-term studie...

Research agreement to advance new imaging technology

... of two-dimensional images which are captured by a receptor as it rotates around the patient into a three dimensional image. While these technologies have provided doctors an invaluable view into the human body, the images often contain flaws. Radiologist Vaseem Chengazi, M.D., Ph.D., an associate profes...

Inhibiting blood to save the brain

...mouse model, the researchers identified a specific receptor called Mac-1 that is expressed by microglial cells and binds to fibrinogen. Mice expressing a mutant form of fibrinogen that failed to bind Mac-1 had fewer inflammatory lesions and less severe MS symptoms. Blocking the interaction between Mac-1 and...

Nevada scientist authors influential AIDS/HIV paper

...n of HIV by eliminating the "door handle" by which receptor molecules on the surface of a white blood cell nor...the drug, you can count the number of CD4 (surface receptor molecules for HIV) on the surface of the cell. If you treat the cell with the drug for a half a day,...

Insight on fruit fly immune system could lead to new types of vaccines, Stanford researchers say

...tudy, the researchers conclude that a much-studied receptor called Toll is involved, as are other processes. Pham is now teasing apart the finer aspects of how the fruit fly protects itself against S. pneumoniae. Schneider and Pham said they hope their work encourages the search for a similar adaptive respo...

Addiction breakthrough may lead to new treatments

...y demonstrating that changes in a neurotransmitter receptor in a particular part of the brain actually pre-dates drug use. Using positron emission tomography (a PET scan), they discovered that rats that were behaviourally impulsive, but which had not been exposed to drugs, had significantly less brain dopamin...

How T lymphocytes attack

... their task, their cell surface carries a membrane receptor which is complementary to the antigen in the pathological cells to be eliminated. Alerted by the presence of this antigen, the T lymphocytes are activated. Having identified an infectious or tumour cell, they bind to it and target it with a fatal l...

Strenuous physical activity associated with lower breast cancer risk

... activity and the risk of breast cancer by hormone receptor type, or which hormones can bind to proteins on the surface of the tumor. Strenuous activity appeared to be associated with a lower risk of estrogen-receptornegative but not estrogen-receptorpositive breast cancers. "In summary, these results prov...

USC-led study suggests exercise reduces risk of developing invasive breast cancer

...east cancers or have characterized risk by hormone receptor status," said Leslie Bernstein, professor of preve...ence in the effect of physical activity by hormone receptor status. "This finding was somewhat unexpected; however, if it is repeated in future studies of ph...

Batten down the hatches against HIV

...nter into a T-cell, the virus must first dock to a receptor known as CD4. Also involved is the co-receptor CXCR4. The use of short interfering RNA strands allows the CD4 and CXCR4 genes of the T-cell to be shut off. The T-cell then strops producing these receptors and the virus cannot find any points of attac...

Updated guidelines advise focusing on women's lifetime heart risk

...ne replacement therapy (HRT) or selective estrogen receptor modulators (SERMs) such as raloxifene or tamoxifen...Hormone replacement therapy and selective estrogen receptor modulators (SERMs) are not recommended to prevent heart disease in women. Antioxidant supplements (...

New class of targeted cancer drugs shows promise in slowing progression of recurrent prostate cancer

...hat blocks the human epidermal growth factor (HER) receptor family shows promise in prolonging the lives of pa...single-agent antibody designed to bind to the HER2 receptor and inhibit the ability of HER2 to pair with other HER family members (HER1, HER2, HER3 and HER4). I...

Drug reduces unscheduled trips to doctor for childhood asthma attacks

...ters. Montelukast sodium, a specific leukotriene receptor antagonist that has been shown to be effective in children, is used to prevent mild, persistent asthma. It reduces the swelling and inflammation that tend to close airways, and relaxes the walls of the bronchial tubes, allowing more air to pass throu...

Gene expression test reveals ER and HER-2 status of breast tumors

...e hormone estrogen and the role of a growth factor receptor known as HER-2 that makes a tumor vulnerable to a ...al growth factor receptor-2 (HER-2) positive. Each receptor status requires different types of treatment. The gene expression tests were 90 percent accurate f...

Mechanism of hallucinogens' effects discovered

...producing mice lacking the receptors, but in which receptor activity could be selectively restored in the cortex. The researchers found that mice without functioning receptors showed no hallucinogenic response to LSD, but restoring the receptors rendered LSD hallucinogenic in the animals. The researchers wr...

Tamoxifen discontinuation rates surprisingly high in clinical practice

...en treatment. Tamoxifen is a selective estrogen receptor modulator that inhibits the stimulatory effect that estrogen has on the development of specific types of breast cancer. Scientists estimate that over 40,000 recurrences are prevented each year worldwide because of this drug. However, the optimal dura...

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(Date:10/29/2014)... as ,facultative, form part—together with other cells—of tissues and ... from the others. However, they have a very special ... cells again. This phenomenon is something that happens in ... tissue growth, thus allowing the regeneration of the organ ... the underlying mechanism that allows these cells to retain ...
(Date:10/29/2014)... organisms in the living world compete with members ... in how much they invest into their competitive ... to get access to high-quality resources, while others ... of the lower-quality resources that are left over ... animal and human societies seems to fluctuate considerably ...
(Date:10/29/2014)... of kidney cancer patients in Europe sheds light on ... an apparent link between exposure to aristolochic acid and ... research, by an international team led by scientists from ... Montreal, underscores the importance of investigating possible sources of ... of the Aristolochia genus, also has been suspected of ...
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