Tag: "receptor" at medical news

JCI table of contents, June 8, 2006

...y found that this involves signaling via Toll-like receptor 2 (TLR2). The results of this study provide important new insights into Treg signaling and how Tregs affect the immune function of regulated T cells. Clinically, the upregulation of Treg function has important implications for the control of autoimmu...

Mechanism for neurodenegerative diseases linked to transport proteins

...seases, including SBMA, in which a mutation in the receptor for testosterone leads to the loss of motor neurons. In the new study, Brady and his co-workers were able to show that polyQ-AR, the mutated protein in SBMA, caused inhibition of fast axon transport by activating an enzyme called JNK that can inhibit...

Serotonin, acting in a specific brain region, promotes sleep in fruit flies

...blems. The researchers also identified a serotonin receptor that affects sleep, and showed that it acts in a specific region of the fly brain known as the mushroom bodies. Interestingly, the mushroom bodies are required for learning and memory in flies. Given that consolidation of memory is one of the functio...

Study evaluates benefits and risks of tamoxifen and raloxifene for reducing risk of breast cancer

...ssue of JAMA. Tamoxifen is a selective estrogen receptor modulator (SERM) that has been used to treat both early and advanced breast cancer for more than three decades, according to background information in the article. Raloxifene is a second-generation SERM currently used as a medication for the preven...

Results good for HER-2 positive breast cancer patients using trastuzumab

...oting protein called human epidermal growth factor receptor (HER-2). These tumors tend to grow faster and are generally more likely to recur than tumors that do not overproduce HER-2. Trastuzumab is the first identified monoclonal antibody designed specifically to attack this overexpressed protein, and is u...

Clinical trial confirms novel EGFR antibody targets tumors but not normal tissues

...t 806 specifically targets epidermal growth factor receptor (EGFR) on a wide range of tumor types but has no uptake by normal tissues. This result is markedly different to other mAbs, which target wild-type (wt) EGFR on normal tissues. According to Andrew M. Scott, M.D., the Director of LICR's Melbourne Cent...

Skin rash in patients treated for liver cancer determines survival

...patinib that prevents two epidermal growth factors receptor (EGFR) pathways from becoming activated in cancer cells. The EGFR pathway has been implicated in the growth and spread of many cancers. When the researchers evaluated the toxic effects of treatment with lapatinib, they found that twenty of the pati...

New sleep medication shows less potential to foster abuse and dependence

...o share abuse liability with BZRAs [benzodiazepine receptor agonists]." The findings also indicate that ramelteon will not produce benzodiazepine-like physical dependence in humans. Thus the authors say these findings are potentially important for the treatment of sleep problems....

Early results find activity in drug that turns on tumor 'death' receptors

...lls, work in tandem with the tumor-necrosis factor receptor (TNFR) super-family, which can signal cell destruc... cells. Herbst suspects that Apo2L and other death receptor agents being developed for cancer treatment will work best when used with chemotherapy and/or radiat...

Better survival seen for early breast cancer patients switched from tamoxifen to Aromasin

...y breast cancer, found that postmenopausal hormone receptor positive patients, which represented 85% of all patients in the trial, who switched to Aromasin reduced their risk of breast cancer recurring by 35% versus patients who stayed on tamoxifen for 5 years. At the earlier time point, a difference in overa...

How sweet it isn't: Repeat episodes of low blood sugar spell diabetic disaster

...I, which activates corticotrophin-releasing factor receptor 2 (CRFR2), impairs the sensitivity of glucose-sensing neurons in the brain. In contrast, administration of CRF, which activates CRFR1, amplifies the response to hypoglycemia. The data suggest that the regulation of the counterregulatory response to h...

Obesity linked to all types of breast cancer

...pected, weight gain increased the risk of estrogen receptor positive tumors, but not of tumors that did not present estrogen receptors. Dr. Feigelson and her colleagues conclude that "these data further illustrate the relationship between adult weight gain and breast cancer, and the importance of maintaining ...

Researchers link two more genes to sudden infant death syndrome

...amined caveolin-3 (CAV3) and the cardiac ryanodine receptor (RyR2) and found molecular and functional evidence in both to implicate them as SIDS-susceptibility genes. Researchers examined the tissue of 135 unrelated cases of SIDS -- in infants with an average age of 3 months old -- that had been referred to M...

A bone of contention in drug-induced osteomalacia

...ugh their activation of the steroid and xenobiotic receptor (SXR), which induces expression of the enzyme CYP3... CYP24, which itself is regulated by the vitamin D receptor (VDR). A 2005 study by another research group that also appeared in the JCI reported that activation...

JCI table of contents, May 11, 2006

...ugh their activation of the steroid and xenobiotic receptor (SXR), which induces expression of the enzyme CYP3... CYP24, which itself is regulated by the vitamin D receptor (VDR). A 2005 study by another research group that also appeared in the JCI reported that activation...

Inhaled steroids help young children breathe but do not prevent chronic asthma

... corticosteroids and had less need for leukotriene receptor antagonists or additional inhaled steroid treatments. The researchers found that the inhaled corticosteroids appeared to slow the growth of the children in the treatment group; however, this effect appeared to be temporary. The difference in growth ...

Long-term estrogen therapy linked to breast cancer risk

...cal records, which they used to record the hormone receptor information. Tumors were classified as positive or negative for estrogen receptor or progesterone receptor based on how they responded to specific hormonal therapies. Throughout the...

JCI table of contents: May 4, 2006

... drugs bind to but do not activate the histamine 1 receptor (H1R), subsequently blocking the allergic response...tial benefit for patients. TITLE: The H1 histamine receptor regulates allergic lung responses AUTHOR CONTACT: Paul J. Bryce Northwestern University Feinberg Sch...

Halting histamine action means hallelujah for hay fever sufferers

... drugs bind to but do not activate the histamine 1 receptor (H1R), subsequently blocking the allergic response. Interestingly, a recent study in Nature reported that mice deficient in H1Rs were still able to mount a Th2 immune response. In an effort to clarify this discrepancy, Paul Bryce and colleagues from ...

Italian researchers find fenretinide cuts the risk of second breast cancers in young women

...ive in pre-menopausal women against both oestrogen receptor positive and oestrogen receptor negative breast cancer Professor Veronesi said that fenretinide appeared to work by re-imposing ord...

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(Date:10/31/2014)... emits over a wide part of the electromagnetic spectrum ... built in Lund, Sweden. The MAX IV facility presents ... together its component parts in a storage - ring ... a few hundred metres. Nevertheless, if these various challenges ... experiments that require source brightness and transverse coherence will ...
(Date:10/31/2014)... Ebola one important hurdle has just been cleared – ... of North Carolina at Chapel Hill and colleagues have ... be infected with Ebola and display symptoms similar to ... current issue of Science , will significantly improve ... desperately needed to curb the worldwide public health and ...
(Date:10/31/2014)...  HITLAB SM , a healthcare innovation and ... HITLAB Innovators Summit SM on December 1, ... partner with the Clinton Foundation,s Health Matters Initiative, ... Business School Alumni Club of New ... Operations Research, bringing together leaders in healthcare and ...
Breaking Biology News(10 mins):A new generation of storage -- ring 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3
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