Tag: "receptors" at medical news
Top anti-arthritis drugs cause skin disease
...dies, infliximab and adalimumab, and the TNF-alpha receptors
etanercept and lenercept. The results of the study show that 25% of patients on therapy suffered from a dermatological condition that led them to visit a skin specialist. In a control group of patients who were not undergoing TNF-alpha blocking ther...
Genetic link to cervical cancer
Certain combinations of genes that encode receptors
on innate immune cells increase the risk of develo...inhibitory signals generated by a group of protein receptors
called killer cell immunoglobulin-like receptors
(KIRs). These receptors
bind to partner proteins t...
Metabolic side effects of antipsychotics are known, but rarely monitored
...hat a patient's genetic make-up of their serotonin receptors
can predict whether a patient will gain weight or ...t risperidone actually decreases alpha 7 nicotinic receptors
in the hippocampus and cortex, big areas for memory," says Dr. Terry. As an expert in drug function...
Exercise, stress management show physiological benefits for heart patients
...oved baroreflex sensitivity, a phenomenon by which receptors
located along the walls of blood vessels respond to changes in blood pressure. These receptors
are connected to the heart by nerves, which carry the message to pump faster or slower in response t...
'Promiscuous' area of brain could explain role of antidepressants
...eeks because as serotonin is elevated, some of its receptors
had to turn off and become desensitized rather than be stimulated," Dani said. "That didn't make a lot of sense to us since desensitization is usually a rapid mechanism." Serotonin and dopamine neurotransmitter systems, which factor heavily in regula...
OHSU scientist helping explain basis of psychotic behavior
...upersensitivity, you see high-affinity dopamine D2 receptors
as the predominant form," said Grandy, a pioneer i... proportion of high-affinity D2 in a population of receptors
in animals that show supersensitivity to dopaminergic drugs," Grandy added. ...
Breakthrough findings by Ume researchers link obesity to diabetes
...ngs of the Ume team show that mice that lack GPR40 receptors
are healthy and experience normal weight gain on a...inding that mice with an increased number of GPR40 receptors
on their beta cells develop diabetes. GPR40 belongs to the class of receptors
targeted by most drugs...
Scientist works to reduce side effects of radiation therapy
... will test whether drugs designed to block certain receptors
in the brain can help prevent brain injury from ra...drugs that block peroxisome proliferator-activated receptors
(PPARs). These receptors
are known to control fat and glucose metabolism, and new evidence suggests ...
Drugs targeted at muscle cells
...t have established that a type of drug targeted at receptors
in the muscle cells increases the metabolism and a...edentary nature of typical Western lifestyles. The receptors
in the muscle cells that were studied are called peroxisome proliferators-activated delta receptors
Genetic variation linked to alcohol dependence found in a Russian population
...et out of control. Activating the function of GABA receptors
usually decreases activity in brain neurons and can decrease activity of the entire brain and body, as occurs in general anesthesia. Some of alcohol's effects appear to be mediated through GABRA2." This gene is often found in persons who do not beco...
Excess oxygen worsens lung inflammation in mice
...om surrounding cells. When adenosine binds to cell receptors
in the inflamed region, it serves as a tissue-protecting stop signal, slowing the flood of damaging inflammatory molecules, the scientists found. From these findings, they reasoned that oxygen therapy given to patients with acute lung inflammation m...
Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
...errin. "We discovered that transferrin can bind to receptors
on the intestinal epithelial cells and be transported across the GI tract to the blood stream," Shen says. "Humans naturally produce transferrin to move iron through the blood to the liver, spleen and bone marrow. It has been used to carry some prote...
Immune system lab model overcomes ethical limits on human hematopoietic stem cells studies
...argets; that the T cells carry a wide diversity of receptors
on their surfaces; and that the immune cells respond normally stimulation by multiplying. Receptors are proteins that recognize specific molecules on bacteria, viruses, cancer cells and other potential targets that stimulate the immune system. A key...
Two studies offer clues about how alcoholic behavior is 'switched' on
...atory have published two studies on how modulating receptors
for dopamine -- a chemical "signaler" in the brain...e scientists increased the number of dopamine "D2" receptors
in strains of mice with genetically varying levels of D2 receptors. Earlier Brookhaven studies have ...
Older adults with insomnia report falling asleep faster with ramelteon
...ew mechanism of action, specifically targeting two receptors
in the brain, MT1 and MT2. The MT1 and MT2 receptors
are located in the brain's suprachiasmatic nuclei (SCN). The SCN is known as the body's "master clo...
Changes in brain receptors linked to seizures and anxiety during the menstrual cycle
...new UCLA study shows that changes in certain brain receptors
can affect seizures and anxiety during the menstru... researchers found that a specific subclass of the receptors
called GABAA receptors
change in the hippocampus during the cycle. These changes take place in a par...
Breast tumor's biological traits guide hormone therapy
...n whether her tumor was positive both for estrogen receptors
(ER+) and progesterone receptors
(PgR+). For women whose tumors were ER+ and PgR+, the best course appears to be tamoxifen for two y...
While on trail of dioxin, scientists pinpoint cancer target of green tea
...otein because it binds to many different cells and receptors
in the body. It turns out that those researchers are trying to duplicate what green tea does naturally. Gasiewicz says drug makers can learn from green tea, which might modulate HSP-90 in a way that researchers haven't seen before. Gasiewicz is a wo...
Antibody combined with cancer drug shows promise against breast tumors
...estroy the vessels feeding the tumor. By targeting receptors
unique to tumor vessels, vascular targeting agents kill tumors without causing damage to surrounding healthy tissue. They also reduce the risk of side effects by operating at lower doses than traditional cancer therapies because they are effective wi...
New class of drugs may treat lung tumors resistant to Iressa and Tarceva
...a complex process of internalization, in which the receptors
take up their ligand [signalling molecule] on the cell surface, move inside the cell, release the ligand and then move back to the cell membrane,"says Haber, a professor of Medicine at Harvard Medical School. "We're starting to appreciate that a ver...
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