Tag: "receptors" at medical news
New study finds that Ramelteon shows potential for circadian phase shifting
...e mechanism of action that selectively targets two receptors
located in the brain's suprachiasmatic nucleus (SCN). The SCN is known as the body's "master clock" because it regulates 24-hour, or circadian rhythms, including the sleep-wake cycle. "For many people, especially those who need to fall asleep earlier...
New data show OAB therapy Enablex® does not impair memory function compared to alternative
...imuscarinic agents, meaning they act on muscarinic receptors
in the body associated with bladder control. "Beyond balancing efficacy, tolerability and safety, selecting an appropriate overactive bladder treatment requires consideration of possible cognitive effects. These data indicate that Enablex may be a go...
Late-breaking Digestive Disease Week news
...ese medications also interact with opioid-specific receptors
outside the brain and spinal cord, resulting in co...ly block the effect of these medications on opioid receptors
outside the central nervous system. Since methylnaltrexone does not cross the blood-brain barrier, i...
Type of stress, not duration, key to heart enlargement
...nced alteration in the function of beta-adrenergic receptors
located on the surface of the heart muscle cells. These receptors, are protein switches that nestle in the cell membrane and are activated by the hormone adrenaline to enhance the heart's pumping action in response to exercise or stress. "When blood...
Early results find activity in drug that turns on tumor 'death' receptors
...evaluate a new type of drug that activates "death" receptors
on cancer cells has found it to be both safe and s...ay to induce cell suicide, through so-called death receptors
that are located on the outside of all cells. These receptors, which are believed to be especially n...
Targeted therapy shows significant benefits over standard treatment for advanced kidney cancer
...s respond to this immunotherapy. Sunitinib targets receptors
on kidney cancer cells that may play a role in tumor growth and the development of blood vessels that feed a tumor. Previous clinical trials, also led by Dr. Motzer, showed that sunitinib caused some renal cell cancers to shrink, but this study is th...
New sleep medication shows less potential to foster abuse and dependence
...that the drug's targeting of the brain's melatonin receptors
rather than its benzodiazepine receptors
make its subjective side effects different from those of old and new sedative hypnotics. The resear...
Health risks continue well after the surgery is over
...uced tissue injury become large, express different receptors
on their surface and, when exposed to a superimposed infectious stimulus like lipopolysaccharide, respond with an overwhelming release of pro-inflammatory cytokines that are harmful to the host." The mice die rapidly and these re-programmed macrophag...
News Tips from The Journal of Neuroscience
...e signaling proteins operate by binding to patched receptors
and trigger intracellular signaling cascades that control such things as tissue patterning during development. Sharghi-Namini et al. examined mice deficient for desert hedgehog (dhh) that is selectively expressed and secreted from myelinating Schwa...
Drug attacks prostate cancer in mouse model by destroying its blood supply
...by inactivating the platelet-derived growth factor receptors
(PDGF-R) on the cell surface. This prevents the receptor's activation either by PDGF binding to it externally or by a signal generated internally by the cell. Activation of PDGF-R stimulates the birth of new blood vessels, promotes cell division and...
JCI table of contents, June 8, 2006
..., drugs that interact with these enzymes and their receptors
may be of potential therapeutic value in obesity. TITLE: Ghrelin action in the brain controls adipocyte metabolism AUTHOR CONTACT: Francoise Rohner-Jeanrenaud Centre Medical University, Geneva, Switzerland. Phone: 41-22-379-54-36; Fax: 41-22-379-52-...
Transporter is possible target for safer pain medicine
...y. Opioid peptides are natural pain relievers with receptors
first identified because they react to opium throughout the body, says Dr. Vadivel Ganapathy, chair of the Department of Biochemistry and Molecular Biology at the Medical College of Georgia. Studies have shown, for example, opioid peptide levels in...
Study uncovers 'significant' functional differences of novel estrogen receptor
... interfere with apoptosis and DNA repair. Estrogen receptors
mediate the majority of the actions of estrogen, i...eptor (hER), which is mediated by specific nuclear receptors
including hER-?66. However, questions regarding the functional significance of cell plasma membrane-...
NYU researchers decorate virus particles, showing potential to enhance MRI capabilities
... particles so that they are recognized by specific receptors
on cell surfaces, we may be able to use MRI to image tumors much smaller than can currently be seen."...
Study reveals biochemical signature of cocaine craving in humans
...ed with a radiotracer designed to bind to dopamine receptors
in the brain. During scanning, the PET camera pick...ound radiotracer so that levels of tracer bound to receptors
can be compared with levels in the blood. As the body's natural dopamine levels rise, this "endogeno...
Altered activity in receptor pair points to further complexity in schizophrenia pathology
...e from patients with schizophrenia. By stimulating receptors
in the prefrontal cortex, the research team tracke...archers to believe that enhanced activity of erbB4 receptors
results in a decrease in NMDA receptor activity. Low levels of NMDA receptor activity are believed...
Sequence of therapies not associated with improved survival from inflammatory breast cancer
...and radiotherapy, followed by endocrine therapy if receptors
are positive) has significantly increased overall survival compared with single-modality or dual-modality regimens, but overall survival remains low compared with that associated with noninflammatory breast cancer," the authors conclude. "Although t...
JCI table of contents: July 3, 2006
...al gland where such hormones are produced. Liver X receptors
(LXRs) are known to limit the accumulation of exce... synthesis in a variety of tissues. TITLE: Liver X receptors
regulate adrenal cholesterol balance AUTHOR CONTACT: David J. Mangelsdorf University of Texas Southw...
Inflammatory processes in arteriosclerosis revealed
... blood vessel wall such that they start to express receptors
for a leukotriene, LTB4. This enables the cell... Solna. The study has investigated all enzymes and receptors
that are involved in the formation and signalling of leukotrienes in arteriosclerotic tissue (harden...
Scripps research scientists test anti-obesity vaccine
...s because drugs seeking to modulate obesity-driven receptors
via agonist or antagonist effects have been remarkably unsuccessful. They are effective only while treatment is maintained and when treatment stops, weight returns. For obesity treatments to work, they must affect energy intake, absorption, expenditu...
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