Protein potentially links diet, obesity and asthma
... new protein in human airway epithelial cells that regulates allergic airway inflammation. This protein adipocyte/macrophage fatty acidbinding protein aP2 is known to regulate the uptake by fat cells of fatty acids and has been previously linked to insulin resistance in diabetes and the development of athero...Cycles of cell death, proliferation key to liver cancer
...ancer is known to involve the NF-kB pathway, which regulates gene expression. In research published in the journal Cell in 2005, Karin and his colleagues at UCSD implicated the pathway's activator, IKK , in chemically induced liver cancer. However, the surprising outcome of those studies was the finding that...Growth hormone stimulators improve physical function in older adults
...ect physical function throughout our lives, and it regulates metabolism and body composition. As adults move into middle age, growth hormone production begins to taper off. Many of the effects of aging increased abdominal fat, reduced muscle mass, and decreased physical function look very similar to the symp...JCI table of contents, June 8, 2006
...Y T cell activity during the immune response: what regulates the regulators? Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress activation of the immune system and in doing so help prevent aggressive immune responses against our own tissues. However little is known abo...Green tea and the 'Asian Paradox'
...G also reduces the amount of platelet aggregation, regulates lipids, and promotes proliferation and migration of smooth muscle cells, which are all factors in reducing cardiovascular disease, he said. Sumpio said other reports show that EGCG prevents growth of certain tumors. Tea, according to studies, also c...Early results find activity in drug that turns on tumor 'death' receptors
...struction of these cells. "Normally, the p53 gene regulates cell suicide in the presence of cell damage, such as that induced by chemotherapy and radiotherapy, but this gene is mutated - and therefore inactivated - in more than half of all cancers. We expect this agent to work even in those patients with muta...New mechanism explains glucose effect on wakefulness
...ttle about how the basic energy molecule, glucose, regulates such wakefulness and other energy-related behaviors. Now, in an article in the June 1, 2006, Neuron, Denis Burdakov of the University of Manchester and his colleagues have pinpointed how glucose inhibits neurons that are key to regulating wakefulness...Baylor researchers develop 'bubble' technique for potential treatment of Type I diabetes
...r had been subsequently lowered. Another gene that regulates insulin production, known as hexokinase I, was successfully delivered using UTMD as well, and resulted in increased blood insulin and decreased blood sugar in the rats. "Not only was their blood sugar lowered, but there was no evidence of any damage...New study finds that Ramelteon shows potential for circadian phase shifting
...N is known as the body's "master clock" because it regulates 24-hour, or circadian rhythms, including the sleep-wake cycle. "For many people, especially those who need to fall asleep earlier than their normal bed time or travelers entering a new time zone, these changes can create a disruption, confusing their...A bone of contention in drug-induced osteomalacia
...A4. The authors conclude that while SXR negatively regulates CYP24 expression and subsequent vitamin D breakdown, it can also enhance vitamin D hydroxylation and breakdown by inducing the expression of CYP3A4. This explains how SXR activators can cause osteomalacia. The study establishes SXR as a potential the...JCI table of contents, May 11, 2006
...A4. The authors conclude that while SXR negatively regulates CYP24 expression and subsequent vitamin D breakdown, it can also enhance vitamin D hydroxylation and breakdown by inducing the expression of CYP3A4. This explains how SXR activators can cause osteomalacia. The study establishes SXR as a potential the...UCSD researchers link novel mutated gene to meal retardation and imbalance
...ough the exact mechanism of how the CEP290 protein regulates cerebellar development remains unknown." In 2004, Gleeson and his colleagues along with scientists at Harvard University discovered mutations in the AH1 gene found on chromosome 6 DNA. The gene is responsible for the most common of three known for...JCI table of contents: May 4, 2006
...fit for patients. TITLE: The H1 histamine receptor regulates allergic lung responses AUTHOR CONTACT: Paul J. Bryce Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Phone: (312) 503-0077; Fax: (312) 503-0078; E-mail: p-bryce@northwestern.edu . View the PDF of this article at: https...Scientist works to improve treatment for brain tumors
...receptor for interleukin 13 (IL13), a protein that regulates the immune system. Debinski combined IL13 with a bacterial toxin to create a cytotoxin drug to target cancer cells and less healthy cells. The efficacy of the first generation of the drug has been has been tested in a clinical trial (phase III) invol...JCI table of contents, April 20, 2006
...surface to normal after injury. TITLE: Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response AUTHOR CONTACT: Julia A. Segre National Human Genome Research Institute, Bethesda, Maryland, USA. Phone: (301) 402-2314; Fax: (301) 402-4929; E-mail: jsegre@nhgri.nih.gov . Vi...Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
... known to be an important part of the pathway that regulates feeding behavior. Scientists at Emory University School of Medicine had previously identified the Hap1 protein as crucial for the normal function of the hypothalamus. In experiments with knockout mice in which the Hap1 gene was eliminated, the mice...ROZEREM (ramelteon) showed significant reduction in time to fall asleep
...N is known as the body's "master clock" because it regulates 24-hour, or circadian rhythms, including the sleep-wake cycle. The FDA approved ROZEREM in July 2005 for the treatment of insomnia, characterized by difficulty with sleep onset. It is approved for long-term use in adults. *ROZEREM is not a control...Brain imaging can predict effectiveness of cognitive behavior therapy for treating depression
... as being negative. The subgenual cingulate cortex regulates emotions and plays a part in turning the amygdala on and off," said Dr. Siegle. "If the amygdala doesn't get 'turned off' in a person with depression, when exposed to negative information, the person may ruminate, going over this information again an...Reduced insulin in the brain triggers Alzheimer's degeneration
...terioration was not related to the pancreas, which regulates insulin for the body. When pancreatic insulin is deficient or the body fails to respond to it, the result is Type 1 or Type 2 diabetes. Previous work by the researchers with postmortem brain tissue of Alzheimer's patients showed a strong link between...Protein that regulates quiescent blood stem cells may enhance recovery from radiation and chemo
... each day. The researchers demonstrated that MEF regulates a little-understood state of quiescence that enabl...lege of Medicine. These results suggest that MEF regulates HSCs' decision to remain quiescent or divide, and the researchers speculate that treatments to dimin...