Lipids play important role in nervous system development
...acellular chatter. "Now we have found this protein regulates lipids and lipids also travel," Dr. Xiong says. The mouse mutant is a clear example of what can happen when the lipids don't travel. The researchers also studied a similar mutant chick embryo that had reduced axon growth. For this paper, they added t...Emotional impairment linked to cognitive deficits in bipolar children
...increased activation in the part of the brain that regulates emotions. When shown positive words, they showed activation in the reward centers of the brain which are often associated with pleasure and addiction. In healthy subjects, positive and negative words activated the regions of the brain associated with...Military funds research on how nicotine impairs bone healing
... along with helping to pass on nerve signals, also regulates the behavior of certain genes. That the body has evolved to use neurotransmitter receptors in this second way, to regulate genes, may explain why the receptors appear on cells that have nothing to do with passing on nerve signals. Central to the prob...Enzyme complex thought to promote cancer development can also help prevent it
.... The M. D. Anderson researchers conclude that Akt regulates the ability of EZH2 to silence genes that are need...lence gene expression. "Our results imply that Akt regulates the methylation activity through phosphorylation of EZH2, which may contribute to oncogenesis," Hung...Scientists pinpoint inflammation gene
...s discovered that a specific gene on chromosome 15 regulates inflammation, a finding with implications for a wi... a variation in the gene's promoter region, which regulates SEPS1 expression as the most important factor among the individuals with the highest levels of infl...Brain protein linked to alcoholism and anxiety
...ety of brain functions. When CREB is activated, it regulates the production of another brain protein called neuropeptide Y. The higher-imbibing P rats were found to have lower levels of CREB and neuropeptide Y in certain regions of the amygdala -- an area of the brain associated with emotion, fear and anxiety ...Researchers shed light on anxiety and alcohol intake
...s. Levels of neuropeptide Y (NPY), a molecule that regulates the function of several neurotransmitters and is known to play a role in anxiety and alcohol-drinking behaviors, also were lower in P rats. One function of CREB is to regulate the production of NPY. "Compared to NP rats, levels of CREB and NPY were i...Gene that controls the severity of asthma identified
...ients with asthma produce MIF, a gene product that regulates immunity, in their serum and in the fluid that lines their lungs. The study by Bucala and his colleagues in Dublin, Ireland, included experiments in mice that are resistant to developing asthma because they lack the gene, and an examination of a hum...... hippocampus, an area buried in the forebrain that regulates emotion and memory, as the origin of fear memory. "This is critical as it changes how and where scientists thought fear was developed," says Zhuo, the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health. "By understanding the biomolecul...Sports doping explored during half-day symposium, Aug. 30
... muscle mass; erythropoietin (EPO), a hormone that regulates red blood cell production, might be genetically engineered to increase endurance; and 'PGC-alpha, a gene involved in muscle signaling, could be used to activate specific muscle fibers to optimize performance. Rosario M. Isasi of the Universit de Mont...Cancer quest boosted by renewal
...built cell death process or 'apoptosis' normally regulates blood cell numbers and how it is overwhelmed in malignant blood cells." He emphasises that the Centre's scientists are excited by the prospect of developing a new approach for the treatment of these malignancies, by exploiting the natural cell death ...Gene found in 90 percent of breast cancers may be cancer vaccine target
...ns have shown TRPS-1 is a DNA-binding protein that regulates how other proteins get produced. It also appears to be involved in recognition of steroids such as estrogen. Radvanyi speculates that the protein may help regulate cell growth and perhaps estrogen recognition. "Based on our findings, we believe that ...FDA approved ROZEREM (ramelteon)
...N is known as the body's "master clock" because it regulates 24-hour, or circadian, rhythms including the sleep-wake cycle. The ROZEREM NDA, submitted in September 2004 by Takeda Global Research & Development Center, Inc., was based on data collected from an extensive clinical research program, including rece...HUP becomes first in region to implant a HeartMate II Left Ventricular Assist System into a patient
...ned heart's left ventricle. An external controller regulates pump speed and a power cable connects the device to a small monitor and power base unit. It's about 1.8 inches in diameter and 3.2 inches long. It pumps blood from the heart throughout the body at up to 10 liters per minute, the full output of a heal...Discovery of T-cell 'traffic control' boosts new drug promise
...T cell trafficking. Goetzl has also shown that S1P regulates T cell trafficking by occupying a receptor on the T cell surface that suppresses the cells' normal response to a "forward march" signal. T cells respond by chemotaxis -- moving from areas of lower to higher concentration of a signaling molecule known...Strong magnetic fields aid severe depression
... the forehead, a region which, among other things, regulates the emotions and steers the psycho-motor reflexes. Effective therapy bad image One in two patients who previously did not respond to other therapies improve after a series of therapy to the extent that therapy can be continued by using medication ...Potent spice works to block growth of melanoma in lab test
...e, and others, previously found that curcumin down regulates EGFR activity that mediates tumor cell proliferation, and VEGF that is involved in angiogenesis. Besides inhibiting NF-kB, curcumin was also found to suppress STAT3 pathway that is also involved in tumorigenesis. Both these pathways play a central ro...Notch protein signaling directs early T-cell development
...the investigators found that Notch, a protein that regulates diverse cell-fate decisions in multi-cellular organisms, is active in very early T-cell progenitors in the thymus of mice. Notch contributes to the subsequent differentiation of these early T-cell progenitors into T cells. "Notch signaling instruct...Diets rich in calcium and vitamin D may decrease risk of PMS
... calcium supplements and vitamin D, a hormone that regulates the absorption of calcium, may reduce premenstrual occurrence and severity. Elizabeth R. Bertone-Johnson, Sc.D., of the University of Massachusetts, Amherst, and colleagues compared the diets and supplement use of 1,057 women aged 27 to 44 years who ......lled the suprachiasmatic nucleus, or SCN. The SCN regulates 24-hour biological rhythms including the sleep-wake cycle and is also called the body's "master clock." WHY: An estimated 60 million people in the U.S. suffer from insomnia, and approximately half of all older adults experience one or more symp...