Stanford researchers find culprit in aging muscles that heal poorly
...longer for injured muscles to heal. Even then, the repairs aren't as good. But now that the researchers have uncovered the conduit that conveys the work orders to muscle stem cells, that knowledge could open the door to new therapies for injuries in a host of different tissues. The key to the whole process...New treatments prevent brain injury hours after stroke in rats
...ty of the DNA repair enzyme PARP-1, which normally repairs cell damage from brain infection. In response to reperfusion following ischemia or brain trauma, PARP-1 is overactivated. As a result, it quickly depletes all available NAD+, in a sense its "fuel," and is unable to repair cell damage, leading to brai...Molecule helps cells plug leaks following lung injury
...atients. Very little is known about how the lung repairs this lining layer, called the endothelium, said You-Yang Zhao, research assistant professor of pharmacology. "We thought it likely that the ability of cells to repair and restore the endothelium might depend on their ability to proliferate and fill ...New sunscreen ingredient to heal sunburn and help prevent skin cancer
...efit from a new sunscreen ingredient that actively repairs sunburnt skin and helps prevent the onset of skin cancer, according to research published in the Journal of Investigative Dermatology. Unlike conventional sunscreen lotions which merely act as a filter for UVA and UVB sunlight, the new ingredient ...JCI table of contents: July 3, 2006
...rom 19 years in minimally conscious state as brain repairs itself Three years ago, 39-year-old Terry Wallis who had persisted in a minimally conscious state (MCS) for 19 years after a traumatic brain injury resulting from a motor-vehicle accident, recovered basic motor function and the power of speech. Usi...JRRD tipsheet: Focus on stroke, Parkinson's treatment, wheelchair durability
...6 percent of participants had completed wheelchair repairs in the past 6 months, 16 percent had completed general maintenance, and 27 percent had completed tire repairs. Neither hours of wheelchair use nor wheelchair age affected repair or maintenance frequency. Better understanding of wheelchair maintenance...Study first to show potential of light-activated gene therapy for knee injuries
...Thus, an SOS system evolved that calls for genetic repairs when UV light causes too many mutations. Specifically, UV light turns on signaling proteins called stress kinases, which activate DNA polymerase, the enzyme that re-builds DNA chains when damaged. Current technologies can direct UV light with great ...Virginia Tech research finds Swedish method of human cartilage repair shows good durability
...esults showed that Brittberg's ACI method produced repairs of excellent durability," said Furey. "But additional research is needed in this area of tissue engineering. Conventional repair methods such as abrasion arthroplasty gave significantly higher wear than that of normal cartilage. Articular cartilage,...Women's silent health problem: Study finds fecal incontinence is prevalent in US women
...t improve the formation of stools, to surgery that repairs the sphincter muscles. In some cases, an artificial bowel sphincter can be implanted under the skin to mimic the natural function of the anal sphincter. Biofeedback which involves daily exercises to improve the strength of muscles used to hold back ...Hospital volume doesn't explain racial disparity in cardiovascular procedure deaths
... angioplasty procedures, abdominal aortic aneurysm repairs and carotid endarterectomy procedures performed from 1998 to 2001. The data were contained in the Nationwide Inpatient Sample, a collection of information from nearly 1,000 non-governmental hospitals across the United States. The analysis confirmed ...Toward the future of cancer prevention
...ted less-effective variants of a gene (XRCC1) that repairs DNA damage from radiation, exhibited longer survival. People with more efficient DNA repair function who were given chemotherapy, particularly platinum-based drugs like cisplatin, had a lower overall survival rate than those with less efficient DNA...Bluhm Cardiovascular Institute surgeons implant heart pump in comparative study of two devices
...h complex bypasses or valve repairs. However, when repairs are not possible, we have a team with the experience and knowledge to evaluate patients and offer transplant if at all possible. If not, we can offer the latest generation of heart pumps, and it is hoped that participants will do well with these." "...Neural cell transplants fight immune attack in mice with multiple sclerosis
...n MS. Evidence suggests that the body successfully repairs some myelin damaged in MS, but not enough to keep up with its loss. Research has shown that adult brains contain stem cells also known as precursors or progenitors that might serve as replacement cells. It has been hoped that, given the right signa...Researchers develop 'genetic blueprint' to predict response to esophageal cancer treatments
...riants of a base excision repair gene (XRCC1) that repairs DNA damage from radiation exhibited longer survival. Those with the GG variant had a median survival of more than 57 months, compared to almost 23 months for patients with a GA variant and only 14 months for those with an AA variant. The researchers...