SKCC's Gennadi Glinsky addresses predicting risk in cancer treatment outcome
.... Applying comparative translational genomics, the researchers selected for analysis the 11-gene BMI-1-pathway si...gh probability of unfavorable therapy outcome, the researchers concluded. However, if this signature expression is not found in tumor cells, there is a high probab...Gene expression pattern predicts multiple drug resistance, treatment failure in pediatric leukemia
...ltiple-drug resistance of leukemic cells is giving researchers crucial information into why standard therapies fa...ues to assess gene expression levels in ALL cells, researchers identified 45 genes closely linked with leukemic cells' ability to resist treatment by at least two ...Alternate view for pathology of AD
A new paper from researchers at the Case Western Reserve University School of Medicine challenges the classic theory that the nerve tangles seen in the brains of Alzheimer's disease (AD) victims are the cause of the disease, but rather proposes that they are a protective respons...Obesity adds risk of cardiovascular disease in siblings in families with a history of heart problems
...ents, such as the Framingham Risk Score (FRS), the researchers say. Traditional FRS scoring measures the likelih...ssure, smoking and diabetes. In the Hopkins study, researchers monitored risk factors, both traditional and BMI, for nine years in 827 siblings under age 60 from f...Tea may help prevent diabetes and cataracts
...control group which did not get tea, they say. The researchers found that both teas decreased glucose levels, which in turn affects other biochemical pathways that accelerate diabetic complications such as cataracts. "Most people, scientists included, believe that green tea has more health benefits than black te...Research reveals emotional trauma parents face when a child is diagnosed with diabetes
... traumatic and life-changing event for parents and researchers doubt whether many of them ever come to terms with it. Those are two of the key findings of a Cardiff University, UK, research study, published in the latest Journal of Advanced Nursing, which explores parents' reactions in the first year after diagn...Drugs targeted at muscle cells
...re recently awarded to an international network of researchers that includes the authors of the article. The mole... Using human muscle cells cultivated in vitro, the researchers were able to show that drugs that bind to PFAAR increase the absorption of glucose in the muscle cel...Melbourne researchers develop safer and more effective 'aspirin'
Monash University researchers and staff of the Melbourne-based biotechnology company Cerylid Biosciences Ltd, have discovered and developed a new class of anti-clotting drugs that appears to be more effective than aspirin at preventing disease-causing blood clots and has fewer si...Sex, age and sun exposure linked to frequency of sunburns
...pants was 30 years (age range, 4 - 68 years). The researchers found that most sunburn days occurred on a person'...M. and thus accumulated the highest UVR dose," the researchers state. "Campaigns to prevent sunburn should aim at reducing the number of days with risk behavior an...Surgery for children with sleep apnea improves quality of life
...mprovements in QOL scores and PSG parameters," the researchers state. "We found significantly larger QOL changes in children who underwent surgery compared with children without surgery. No strong association was identified between QOL scores and PSG parameters." "The improvements in QOL were seen six months a...Anthrax treatments' cost effectiveness shown in Stanford study
...terrorist anthrax attack? Nearly four years later, researchers may be closer to an answer. A study from the Veter...y of exposure for any given type of attack, so the researchers chose estimates based on reviews of literature and expert opinions. They estimated the probability o...Variant in gene associated with telomeres predicts longer survival of deadly brain tumor
... this deadliest form of brain cancer, according to researchers at The University of Texas M. D. Anderson Cancer C... telomerase. This study of 301 patients, which the researchers believe is the largest to date of patients with glioblastoma multiforme, found that the 36 patients ...More evidence suggests statins help cut risk for advanced prostate cancer
...ar study of more than 30,000 health professionals, researchers at Johns Hopkins and Harvard found that the longer...e before study participants got cancer. Still, the researchers caution that data are not conclusive enough to warrant prescribing the drug to reduce cancer risk al...U of T research examines nursing home quality of care
...is heavily studied in the U.S.," says Hillmer. The researchers reviewed data on factors such as staffing, use of restraints and pressure ulcers. Results indicate that not-for-profit homes south-of-the-border generally perform better than for-profit homes, especially when it comes to measures of patient care. At ...Obesity hits below the belt: Overweight Americans suffer higher rate of knee cartilage tears
...of its kind, University of Utah School of Medicine researchers found the likelihood of tearing the meniscus, the ...ectively, more likely to tear the cartilage, the U researchers report in the May edition of the American Journal of Preventive Medicine. All the extra weight Ameri...Clinical trial of gefitinib for advanced lung cancer closes early
...n Bethesda, Md., and was conducted by a network of researchers led by the Southwest Oncology Group (SWOG), Ann Arbor, Mich. AstraZeneca Pharmaceuticals LP, Wilmington, Del., which manufactures gefitinib, provided the agent for the trial under the Clinical Trials Agreement with NCI for the development of gefitini...Number and quality of kidney transplants much greater if national matching program adopted
... The transplants are performed simultaneously. The researchers have developed an interactive Web site, www.Optim... a small (regional) or large (national) pool. The researchers compared the optimized algorithm with the scheme currently used in some centers and regions. The mod...Combination chemotherapy shows small survival benefit in advanced stomach cancer
...ced stomach cancer treatments, scheduled for 2006, researchers will examine the effects of anticancer therapies still in clinical trials that specifically target stomach cancer cells...Some Alzheimer's patients can benefit from drug memantine
...ed. To account for the missing data, the Cochrane researchers also gathered publicly available information on th...s would still tend in favor of the drug's use, the researchers concluded. Two of the unpublished studies considered in the Cochrane review examine the drug's effec...Mercury levels and cognitive function investigated in adults
...of subjects exceeded the government guideline. The researchers analyzed the blood samples of 474 study participan...ts in the different aspects of brain function, the researchers concluded that overall the data did not provide strong evidence that mercury at these levels had an ...