Tag: "resistance" at medical news
JCI table of contents: January 19, 2006
...sceptible to EBV infection they demonstrate normal resistance
to other pathogens, which the authors suggest may be due to the mature IgM that is ultimately produced by these IgM+CD27+ B cells. TITLE: Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotypeswitched, memory B cells in ...
Older drugs may be good stopgap treatment for malaria in Africa
...ccess to artemisinin drugs and areas where malaria resistance
to Fansidar and amodiaquine is still low. The rev... be considered useful and safe only in areas where resistance
to both drugs is low. They warn that resistance
may have increased since the studies in the review, ...
JCI table of contents, January 26, 2006
...E: Glucocorticoids exacerbate obesity and insulin resistance
in neuron-specific proopiomelanocortin-deficient mice AUTHOR CONTACT: Malcolm J. Low Oregon Health & Science University, Portland, Oregon, USA Phone: 503-494-4672; Fax: 503-494-4976; E-mail: firstname.lastname@example.org View the PDF of this article at: https:/...
Mathematics and statistics combat epidemics & bioterror
...za-like illness, to microbial strains with unusual resistance
profiles. As a test bed, Platt and colleagues wil...phylococcus aureus, and from a national antibiotic resistance
monitoring consortium (55 hospitals in Argentina). Co-investigators at Brigham and Women's Hospital...
Avantogen and Innovate merge key oncology program, RP101, RP101
...ith cytostatic drugs to prevent the development of resistance
to chemotherapy. In early 2005 the partners announced dramatic results observed in the clinical pilot study ofRESprotect in which thirteen pancreatic cancer patients in stage III and VI of disease weretreated with RP101, and gemcitabine plus cisplati...
Call not to use certain type of anti-viral drugs for influenza a virus for 2006 flu season
... Oct. 1 through Dec. 31, 2005, and tested for drug resistance
as part of ongoing surveillance. "Of the 209 A (H3...s screened, we found an alarmingly high adamantane resistance
rate of 92 percent," the researchers report. "These viruses were isolated from patients residing in ...
Obesity may be factor in accelerated type I diabetes in some patients
...nd fuel them. Type 2 diabetes results from insulin resistance
(a condition in which the body fails to properly use insulin), combined with relative insulin deficiency....
Unique vascular dysfunction in women's heart disease described in major journal supplement
...en on coronary angiography, it results in abnormal resistance
that limits blood flow to the heart tissue. But without angiographic evidence of a blocked artery, a woman's symptoms are likely to be discounted. Women's symptoms often are different than men's, too, contributing to under-diagnosis. As the disease i...
Researchers break chain of biochemical events that brain cancer cells use to evade therapy
...researchers have found a way to decrease the cells resistance
to therapies that are designed to trigger cell death. The findings resulted from laboratory experiments conducted at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute and are based on the manipulation of a series of intricate bioche...
Macrophage signaling may affect hormone resistance in prostate tumors
...a mechanistic explanation for at least one form of resistance
to androgen antagonists. "It was of particular interest for us to determine whether a macrophage/prostate cancer cell interaction occurs, if it is a common event in prostate cancer, and whether this serves as a source of inflammatory signals capable...
Glaucoma patients appear to have increased eye pressure during sleep
...ith the heart when lying down, which increases the resistance
in flow of fluid in the eye and may create additional pressure, they write. Takeshi Hara, M.D., Jichi Medical School, Tochigi, Japan, and colleagues measured the intraocular pressure of 148 patients with untreated glaucoma at the Hara Eye Hospital in...
MIT thinks small to find safer metals
...ipulating the structure of metals to improve their resistance
to cracking, corrosion and other wear and tear, Schuh said. Schuh already has tested steel coated with chromium and his new alloy, and the alloy has held up better against some types of corrosion. Schuh said that while replacing chromium as a metal c...
Obesity is a significant predictor of periodontal disease
...ysis of this national sample suggests that insulin resistance
mediates the relationship between obesity and peri...in resistance. Individuals in the highest insulin resistance
category lost 1.1 more teeth compared to individuals in the lowest category. "People who have a high...
Scientists uncover genes for virulence in strain of community-acquired MRSA
...ists have identified the genes responsible for the resistance
and virulence of one of the most predominant strai...0 has acquired mobile genetic elements that encode resistance
and virulence determinants that could enhance fitness and pathogenicity."...
Chocolate milk could be key to longer, healthier life
...ell known that consuming proteins and sugars after resistance
training increases the synthesis of proteins used for force i.e. it builds muscles. Dr Miller's research will tell us whether doing the same after aerobic exercise can also increase the synthesis of mitochondrial proteins which affect our ability to ...
Johns Hopkins scientists exploit novel route to reverse enlarged hearts in obese mice
...oned that CNTF might be a way to get around leptin resistance
by activating a related signaling pathway with similar effects on body weight and metabolism," he says. Hare and his colleagues tested the idea on mice with left ventricular hypertrophy (LVH), a condition in which the left ventricle expands and stif...
Insulin levels in African American children worsen through puberty
... and ethnicity-specific characteristics of insulin resistance
in childhood and adolescence. They evaluated the d...unique effect on beta cell compensation to insulin resistance
in young African Americans. Puberty is a transient phase that may act as an accelerator to increase ...
PDT kills drug-resistant bacteria, fungus in lab tests
...going cancer therapy, HIV patients who demonstrate resistance
to antibiotics and the elderly with persistent oral infections." Photodynamic therapy is based on the propensity of certain types of cells or organisms to absorb light-sensitive drugs. This selective retention allows researchers to direct a laser b...
Protein that regulates quiescent blood stem cells may enhance recovery from radiation and chemo
...apacity for repopulation and demonstrated enhanced resistance
to the effects of chemotherapeutic drugs and radiation, which is also seen in wild-type mice transplanted with MEF-deficient HSCs. "This feature can also be helpful to maintain HSCs in an undifferentiated state during gene therapy protocols," explai...
Hopkins study shows low-dose aspirin suppresses clumping of blood platelets in both sexes
... In this test, an ohm is the measure of electrical resistance
caused by platelets as they impede the flow of electricity in a wire probe inside a test tube filled with blood. Moreover, platelet aggregation was largely suppressed in at least three other key pathways related to their function when platelets were...
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