Hope for arthritis stems from within
... and can even cause as much damage as good. "We're responding to a real need," said reader in bioengineering Dr Bahaa Seedhom. "Orthopaedic surgeons are looking for ways to repair cartilage defects in young people which will delay, maybe even prevent, the need for total knee replacement." The bioengineers have ...JCI table of contents, January 26, 2006
... now show that the reason some Asians have trouble responding to GTN is that 3050% of this population possess an inactive mutant form of the gene known as ALDH2*2. The study, which appears online on January 26 in advance of print publication in the February 2006 issue of the Journal of Clinical Investigation, e...Immune system response to viral DNA is unique
...findings is how this newly described system avoids responding to genomic DNA that is contained within all cells. "If this 'tolerance' to self DNA were to break down, cells might mount an antiviral response against their own DNA," he said. "Further characterization of this pathway will shed light on the mechani...Epidural injection does not reduce long-term pain for people with shingles
...h severe acute pain from herpes zoster who are not responding to standard analgesic therapy."...Mutation that protects against HIV infection may raise risk of West Nile virus illness
...larify the roles of various immune system cells in responding to WNV infection. They discovered that while most mice survived WNV infection, mice genetically engineered to lack CCR5 receptors suffered rapid and uniformly fatal infection by the virus. Further investigation showed that CCR5 promoted the movement ...Mysterious condition still more prevalent among Persian Gulf vets
... CMI without serving in the field of combat may be responding to other types of life stress, such as divorce, job pressure or a death in the family. Blanchard currently is conducting a follow up study of 100 individuals with CMI and 100 without CMI. The study includes an extensive evaluation of participants' st...New generation clinical trials could save time and money, improve patient care
...ombinations and use biomarkers to determine who is responding to what medication," says Berry. "At the end of the day, when they enroll the last patient in the study they want to be able to treat that patient optimally depending on the patient's disease characteristics. Using a Bayesian approach, the trial desi...Initial results help clinicians identify patients with treatment-resistant depression
... clinicians face. For example, if a patient is not responding adequately to an initial medication in 4 or 6 weeks, what is the next best treatment option? Beyond just judging safety and efficacy, STAR*D measured practical outcomes, including, in subsequent phases of the study, how well the individual is actu...Free care by Florida emergency physicians climbs faster as uninsured patient visits increase
...are they provided in 1998. The 83 physician groups responding provided substantial uncompensated, or free, emergency care, ranging from 26 to 79 percent with an average of nearly 47 percent. Uncompensated services are those for which no payment is received from either the patient or from a public or private in...Government reforms may bring an end to free healthcare
...ect of an NHS led totally by patients, with supply responding purely to consumer demand without any recognised cap on expenditure." If the Government does not change tack, this "can only lead to user charges," they warn. Current UK policy seems based on US systems, say the authors. But these may not be transf...Immunological karma: T cells reactive to old flu infections make unrelated viral infections worse
... flu) may come back to haunt you, by overzealously responding toa subsequent, unrelated viral infection like EBV, thereby increasing theseverity of the immune response and causing IM. Their results appear onlineon November 23 in advance of print publication in the December issue of theJournal of Clinical Invest...Thanksgiving gluttony misaligned with 'intuitive eating' approach examined in new study
...o interpret body signals, cravings and hunger, and responding in a healthy, positive, nurturing way. Learning the body's signals can be difficult at first, but Hawks suggests thinking about hunger and satiety on a 10-point scale, where "10" is eating until one is sick and "1" is starving. Intuitive eaters keep...Imperial receives Gates Foundation grant to develop new tests for managing AIDS treatment
...ollege and the Bill & Melinda Gates Foundation are responding to these urgent pleas for help."...Magnetic probe successfully tracks implanted cells in cancer patients
...cines" have been disappointing, with some patients responding very well but others not at all. A critical issue behind each patient's success on the treatment, however, is whether the cells get to the lymph nodes, where the immune system's fighters are normally "trained" by dendritic cells. Until now, there's b...Neurons generated in the adult brain learn to respond to novel stimuli
...previously unencountered odors and in subsequently responding to those smells. "These contrasting responses suggest that adult-born olfactory neurons have a unique role in the brain, becoming linked to new smells while the older neurons essentially step out of the way. And since adult-born neurons are continu...Sexually satisfied but feeling frumpy: It's body image, not 'the change'
...us did not have a significant impact on the sexual responding of the women in this study." Analysis of the surv...sults support a link between body image and sexual responding that needs further study." The study is detailed in a paper, "Feeling Frumpy": The Relationships Be...Vitamin D, taxotere combination extends the lives of men with advanced prostate cancer
...rostate cancer research subjects who are no longer responding to hormonal therapy, a condition known as androgen-independent prostate cancer (AIPC). Two hundred, fifty subjects participated in the study at 48 sites between September 2002 and January 2004. The estimated survival of subjects receiving DN-101 ...Tracking desertification with satellites highlighted at UNCCD COP
...t and demonstration of a handsome software package responding to needs and requirements of our users to better monitor and assess desertification and land degradation using Earth Observation technology" explained Olivier Arino of ESA. "The intention is that once the system has been successfully demonstrated it ...Booster vaccination against hepatitis B not necessary for long-term protection
...at infant and adolescent immune systems can recall responding to hepatitis B more than 10 years after immunisation. Professor Zanetti concludes: "In light of our findings, the use of routine booster doses of hepatitis B vaccine does not seem necessary to maintain long-term protection in immunocompetent individ...Physician pay-for-performance programs may produce little gain in quality
... little evidence, clinicians and policy makers are responding to a major policy trend, while researchers determine how to inform those decision makers. In this context, investigators and research funders need to develop strategies that address 4 fundamental aspects of research: study design, selecting theory-dr...