Findings about anti-cancer agent could make it more effective
...e DNA, the genetic "code" found in all cells. The results were reported in Anaheim, Calif., today at the American Association for Cancer Research's 96th Annual Meeting and will be published June 1 in Cancer Research. Eleven years ago, Gmeiner set out to develop a compound that would be more effective and h...CML found to wield 'death factor' that kills normal blood marrow cells
ANAHEIM - Based on surprising results from animal experiments, researchers at The University of Texas M. D. Anderson Cancer Center have revamped common beliefs about how chronic myeloid leukemia (CML) functions within bone marrow - a discovery they hope may some day lead to additional th...Technique may speed drug production, reduce costs and waste
...ducts. "This new method only takes three steps and results in less waste," says Lautens, the NSERC-Merck Frosst Industrial Research Chair in New Medicinal Agents via Catalytic Reactions and AstraZeneca Professor of Organic Synthesis. Indoles are ring structures containing carbon and nitrogen. In the process,...Increasing benefit seen in novel drug that treats Gleevec resistance
...usly being given higher doses of the drug. "So the results change daily as patients fare increasingly better ...es points out. Despite what he calls very exciting results from the use of AMN107, he stresses that CML patients should not think that they need to switch to t...Electroshock therapy speeds improvement in schizophrenia patients
...y compared to treatment with antipsychotics alone results strongly favor the medication group," reviewers found. They also found "very limited data" suggesting that people treated with ECT are less likely to relapse. Further, one trial indicated that the combination of ECT and antipsychotics offered signif...Early detection of lung cancer
...arly-stage detection of lung cancer. The published results correspond to the first 1000 persons who took part...the early detection of lung cancer. Once the first results are published, the project will continue to review, by means of CAT, those patients who have not dev...Study links cigarette smoking with progression of multiple sclerosis
...ntrol neurological damage from the disease. Study results appear in the March 9, 2005 issue of Brain. Miguel Hernn, lead author of the study and an assistant professor of epidemiology at HSPH, noted that "the findings are interesting because no modifiable risk factors for the progression of MS are ...Study shows antibiotic treatment does not reduce risk of secondary cardiac events
...moniae in causing coronary heart disease, the ACES results do not tell us anything about a possible role of C. pneumoniae in the early development or acceleration of disease in the coronary arteries," said the study's principal investigator, Dr. J. Thomas Grayston, professor of epidemiology in the University...Feeling safe and secure? CUMC scientists find it's all in the caudoputamen
...e active when the mice felt safe and secure. "Our results show there's more to the feeling of safety and security than the simple absence of danger," Michael Rogan says. "We have found that there is another part of the brain that is involved in calculating how much protection or shelter is in the environmen...Better referral training for emergency doctors helps improve patient care
...e implemented at the Lister Hospital with positive results and there has been widespread support for the new approach. Teaching for EM junior medical staff is now focused on this area. The topic of referrals now has more prominence and role playing has been introduced. New doctors are not allowed to refer o...New study shows antibiotic treatment does not reduce risk of secondary cardiac events
...tle, the study's principal investigator. The ACES results are confirmed and extended by the similarly negative findings of the PROVE-IT trial published in the same issue of the New England Journal of Medicine. PROVE-IT tested a different antibiotic, a fluoroquinolone, and used a different treatment schedule...New research pinpoints best treatment for stroke
...that do present in time can receive treatment that results in hemorrhage. A 2003 study published in Stroke wh...lts of the study presented shows that CT perfusion results correspond exceedingly well to MRI studies on several parameters including measuring cerebral blood ...Pregnant women with epilepsy face dilemma
...oritative source for current clinical and research results on all aspects of epilepsy. As the journal of the International League Against Epilepsy, Epilepsia presents subscribers with scientific evidence and clinical methodology in: clinical neurology, neurophysiology, molecular biology, neuroimaging, neuroc...Propensity for obesity, diabetes, may occur in utero
...ers returned to normal during the suckling period, results showed, but islets from 12-day-old suckling 2-HC rats showed a capacity for insulin oversecretion when maintained in culture medium containing high glucose levels. By the 28th day, approximately 4 days after weaning to rat chow, 2-HC rats once again...Canadian youth 4th highest in international obesity study
... surveyed. While difficult to explain, the dietary results only underline the importance of focusing on physical activity rather than food intake as the primary way to combat overweight and obesity, the researcher emphasizes. "The adolescent obesity epidemic is a global issue," concludes the paper, which app...Anti-malaria drug combination could help address treatment crisis in Africa
...centre, Paris France) and colleagues describes the results of a randomised trial, which found that the effectiveness of the artemether-lumefantrine drug combination was very high, exceeding 96%, whether given supervised or unsupervised. Adherence to the complicated, twice-daily, three-day regimen might be su...'Virtual colonoscopy' effective in finding most polyps but may miss small ones
...re is no evidence that availability of the CT scan results in more screenings being done. CT scanning uses computers and software to display images of the colon as if the viewer were seeing the inside of it through an endoscope, the instrument used in traditional colonoscopy. It does not require sedation, a...Rare surgery performed to remove pancreas, prevent diabetes
...rvives. Only a few other cases were attempted, and results were not uniformly good, so the procedure fell out of favor until recently, when new advances in cadaveric islet cell transplantation made outcomes more favorable....High levels of immunosuppressant may lead to tumor recurrence
...sporine levels did not affect rejection rates. The results of this study appear in the May 2005 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on beha...Environmental factors, particularly air pollution, increases risk of myocardial infarction
...nate affect on people. The new thesis presents the results of Mats Rosenlund's research into environmental fa...of pollutant emission since 1960. According to the results of the study of the hardness of the drinking water, there is no evidence that the hardness of the wa...