Regulator of lipid metabolism ensures high quality breast milk
...etter understanding of PPAR could help explain the role lipids and inflammation play in hair loss and other skin disorders and facilitate the development of new treatments for these diseases. PPAR acts as a genetic switch, sensitizing the body to insulin and lowering levels of circulating glucose. In fa...New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
...he first evidence that the XBP1 protein may play a role in breast cancer pathways. Through molecular profiling of the downstream effects of the spliced XBP1, Dr. Clarke and his colleagues discovered that expression of several anti-apoptotic genes responsible for programmed cell death including BCL2 a...Pathway links inflammation, angiogenesis and breast cancer
...esis - the creation of new blood vessels - plays a role in cancer formation related to the inflammatory pr...Fa). "What we found is a previously unrecognized role for IKKbeta, a protein kinase activated by TNFa," Hung says. IKK inactivates a cancer-suppressing pr...Bioengineering to prevent iron deficiency?
...authors believe genetic engineering can play a key role eg. The iron content in rice can be increased two- to three-fold by introduction of the ferritin gene from the soy bean. Another problem the reduction of bioavailable iron due to high phytate content could also be solved by introducing genes which...Hormone regulates fondness for food
...ding or appetising properties of food play a major role and can lead to overeating when they over-ride the biological cues that govern hunger and fullness. Understanding eating behaviour therefore means that we must take into account physiological and hormonal pathways and also the brain processes evok...Stress may leave your mouth a mess
...ers speculate that the hormone cortisol may play a role in the possible connection between stress and periodontal diseases. A study in the July issue of the JOP found that increased levels of cortisol can lead to increased destruction of the gums and jaw bone due to periodontal diseases. It is well know...Obesity linked to hyperparathyroidism in chronic kidney disease
... in CKD." Parathyroid hormone plays an important role in maintaining normal bone structure. When hyperparathyroidism develops, it can lead not only to bone abnormalities but also to increased rates of cardiovascular disease and death. Although decreased kidney function is the main reason for hyperpara...Diets high in choline may increase risk for colorectal polyps
...lts were contrary to expectation based on cholines role [in one-carbon metabolism], there is a potential b... cancer. Clearly, one-carbon metabolism and its role in [cancer development] is more complicated than originally anticipated, and our understanding of th...Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
...g that non-pharmaceutical interventions may play a role in planning for future influenza pandemics, accord...onpharmaceutical interventions can play a critical role in mitigating the consequences of future severe influenza pandemics and should be considered for inc...Novel candidate biomarker for heart failure also strongly predicts risk of death
...s have suggested that ST2, which appears to have a role in the inflammatory response, also may be expressed within the heart in situations involving stress to the cardiac muscle, including heart failure. To more closely examine ST2s potential as a heart failure biomarker, the research team analyzed data ...ACC/AHA release revised UA/NSTEMI guidelines
...d. Because platelets are thought to play a key role in recurrent heart attack, the anti-platelet therapy clopidogrel is now recommended for at least one year after placement of a drug-eluting stent and shorter term for bare metal stent and with medical therapy. In addition we are emphasizing the value...New research finds high prevalence of smoking among physicians in China
... the general population. Physicians can play a key role in encouraging smokers to quit, yet up to now, little has been known about Chinese physicians attitudes and practices regarding smoking. In this first-of-its kind-study, researchers found that 23 percent of 3,552 hospital-based physicians surveyed we...Fat is the new normal, FSU researcher says
...ording to Heiland. Biological forces also play a role in the rise of obesity. An additional pound of body weight is more likely to be fat, which does not metabolize calories nearly as well as muscle tissue, Heiland explained. Therefore, any increase in calorie consumption -- say, one more cookie each da...Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
...ess going. Dong and his colleagues examined the role of TOPK. This enzyme is not very active in normal tissues, but it is quite active in cancerous cells taken from blood, breast, prostate and colorectal tumors, among others. The onset of cancer could trigger the permanent turning-on of TOPK. One piece...National quality agenda, payment reform, care integration keys to improving quality, patient safety
... that the federal government should play a leading role in helping finance health information technology. Fifty-eight percent said that insurers/payers should step in. As expected, health information technology was identified as a promising vehicle for improving quality and efficiency, said Anthony Shih...Nottingham center to help UK to meet its carbon targets
....1m for a new centre that is set to play a crucial role in the fight against climate change. The Centre ... and other energy-intensive industries that have a role to play in helping the UK to meet its 2050 target of 60% reduction below 1990 levels. ...Brief motivational interviews work best long term for college students sent to alcohol counseling
...refore, in-person interventions may have a special role for mandated students, or alternatively the effects of in-person interventions may last longer than written feedback (which has not been tested in other studies)."...Landmark study finds adult Delawareans with disabilities in only 'fair' to 'poor' health
...ved quality of life." Caregivers play a critical role in the lives of Delawareans with disabilities. Nearly two-thirds of the respondents indicated they need help with routine tasks such as household chores and shopping, and about a third require assistance with eating, bathing and dressing. Most care...Obese girls less likely to attend college
...h and behavioral issues seem to play a significant role in keeping obese girls from enrolling in college. The study found obese girls were more likely to consider committing suicide, use alcohol and marijuana and have negative self-images. The disconnect between obesity and college enrollment was more...Should adult male circumcision be recommended for HIV prevention in the US?
...60%. While adult male circumcision may also have a role to play in preventing HIV transmission in the US, ...) in a paper in PLoS Medicine, "the extent of this role on a population basis is unknown." Patrick Sullivan (Division of HIV/AIDS Prevention,CDC) and coll...