Mayo Clinic researchers find evidence for traumatic cause of carpal tunnel syndrome
... lining "The idea is that if we can identify the sequence of events that lead to carpal tunnel syndrome, we can design more effective interventions to prevent or reverse it," according to Peter Amadio, M.D., the Mayo Clinic orthopedic surgeon who led the NIH-funded research team. While rest, exercise and ...Order of chemotherapy, radiation has no effect on breast cancer survival
... of dying from breast cancer. "However, the best sequence of administering these two types of therapy for early stage breast cancer is not clear," Hickey said. "As far as I know, there are few good randomized trials evaluating the different timing of radiation. This is one of the problems about deciding o...DNA computing targets West Nile Virus, other deadly diseases
...cks, a human player makes a "move" by adding a DNA sequence corresponding to their move in the eight remaining wells. The well chosen for the move by the human player responds by fluorescing green, indicating a match to the player's DNA input. The move also triggers the computer to make a strategic counter-mo......on completely different sites in the physiological sequence of pathogens than current medicaments. Platensimycin, recently isolated from the mushroom Streptomyces platensis, is such an agent. A Californian team of researchers is now the first to synthesize this natural product completely in the laboratory-...Study shows six-injection allergy vaccine tames hay fever for at least 2 years
...Berkeley, CA. Short for "Amb a 1 immunostimulatory sequence conjugate", AIC contains a short piece of DNA know...stem reactions. In AIC, this immunostimulatory DNA sequence is linked to a portion of the molecule that causes ragweed allergy (known as 'Amb a1'). Allergies...New allergy vaccine provides long-lasting hay fever relief after just 6 weeks of shots
...o (UCSD) had previously observed that a particular sequence of DNA, derived from bacteria, shuts down a T-helper cell (Th2) involved in the body's inflammatory response. Creticos and his team, recognizing that allergic disease is driven by Th2 inflammation, then embarked on a series of studies to evaluate the...Experimental ragweed therapy offers allergy sufferers longer relief with fewer shots
...gen, Amb a 1, coupled to a unique short, synthetic sequence of DNA that stimulates the immune system, reduced allergy symptoms in adults for at least one year when given just once a week over a 6-week period. The therapeutic agent was provided by Dynavax Technologies Corp., based in Berkeley, CA. "For almost...Mutation plays key role in hypertension
...s and lead author of the study, determined the DNA sequence of the stretch of the kinase gene that controls how often it is copied, and thus controls the level of kinase in the cell. She found a mutation in the hypertensive animals -- an insertion of a small extra piece of DNA. The insertion changes the shap...Seeing two figures in coordinated action helps brain pick out movements of one
...ots of one figure and added many other dots to the sequence to mask the action. The researchers were able to v... Neri, who also participated in the study. "If the sequence is desynchronized, we can tolerate 10 dots. When viewing synchronized action, we can tolerate a mini...JRRD tipsheet: Focus on stroke
...be unsuccessful if a minimum level of phonological sequence knowledge does not exist; therapies that pressure subjects to communicate verbally can achieve clinically important gains in communicative ability. This study also demonstrated the importance of a careful analysis of the patient's language ability be...Quick diagnosis of flu strains possible with new microchip test
...of spots of genetic material--DNA or RNA--of known sequence onto a microscope slide. The spots, called probes,... part, on the ready public availability of genomic sequence data, notes Karen Lacourciere, Ph.D., NIAID influenza program officer. In addition to flu genome se...New lab technique churns out fungus' potential cancer fighter
...nal of the American Chemical Society, outlines the sequence of steps showing how Boeckman's group inserted, removed, or altered the three-dimensional and chemical structure of their compound until they produced complete rasfonin. Diagrams of the complete process are available on the Web at pubs.acs.org . "Ve...Brain chemical plays critical role in drinking and anxiety
...y and his colleagues injected DNA of complementary sequence to the gene of the protein, called brain-derived neurotrophic factor (BDNF), into the brains of rats to block the gene from expressing BDNF. The "anti-sense" DNA was injected into three areas of the amygdala, an area of the brain associated with emot...Teens and smoking: Why cessation interventions should start after the first puff
...esearch study, Gervais and colleagues describe the sequence and timing of 12 milestones (6 related to cigarette use and 6 to symptoms of nicotine dependence) among grade 7 students. They found that symptoms of nicotine dependence can take hold long before regular smoking, even after the first puff in some cas...Duke researchers link newly discovered gene to hereditary neurological disease
...erative disease. By meticulously examining the DNA sequence of those genes, the researchers located mutations -- changes in the DNA sequence -- in the REEP1 gene among people who have hereditary spastic paraplegia but not in their unaffected...Large-scale cross-platform study of research microarrays uncovers high concordance across platforms
... Using probe sequences that were matched at the sequence level (RefSeq and RefSeq exon), improved consisten...ison framework that matched the transcripts at the sequence level," said Kuo. "This is a first report with a relatively large-scale initiative in which the sequ...New fruit fly protein illuminates circadian response to light
...examination of the protein produced by the mutated sequence led researchers to JET, a new protein within the F...ag flies by genetically replacing the mutated gene sequence with the normal sequence, which led to the production of the wild-type (control) JET protein. When t...Radioactive scorpion venom for fighting cancer
...rocedures for the therapy, currently in the second sequence of phase-II human trials, which involve higher doses of radiation than the earliest trials. "The health physicist has the duty to ensure to ensure that these therapies are conducted both legally and safely," Jackson says. "Obviously, a key objecti...Where the brain organizes actions
...nts, the researchers asked volunteers to execute a sequence of button presses when they saw colored squares or...al action. Superordinate action chunks included "a sequence of categorization tasks, like sorting a deck of playing cards first by color, then by suit, then by ...Gut microbes' partnership helps body extract energy from food, store it as fat
...ions, Gordon and his colleagues are completing the sequence of the M. smithii genome and sequencing the genomes of many other members of the normal human gut microbial community. This effort is part of a human gut "microbiome" project. "We believe that this project is a logical extension of the human genome ...