Fc gamma receptor gene variants associated with rheumatoid arthritis
...DRB1 alleles encoding the 'shared epitope' protein sequence (SE positive), a known risk factor for RA, have a 10 times higher risk of developing RA than SE negative individuals with other FCGR3 variants. The Fc gamma receptors play important roles in the initiation and regulation of many immunological and in...Gene for B-cell development factor might be involved in multiple sclerosis
...nce of a polymorphism at a single point in the DNA sequence of the gene EBF-1 also called a single nucleotide polymorphism (SNP) - in 356 patients diagnosed with MS and 540 healthy individuals acting as controls. Both groups consisted of white Spanish individuals. The authors also compared the variants of a ...Penn study finds physically abused boys may be more likely to commit domestic violence as adults
... be able to make major strides toward breaking the sequence of aggression."...Retinoblastoma researchers find success with two-drug combination
...s. The investigators made their findings during a sequence of experiments. First, they tested the ability of drugs and drug combinations to kill retinoblastoma tumors removed from patients and grown in tissue cultures. Then the team determined how much drug to use, and how often to use it, by doing pharmacok...Fox Chase study: Radiation then tamoxifen after lumpectomy for early-stage breast cancer pts
...ENVER--Fox Chase Cancer Center researchers say the sequence of tamoxifen and radiation following lumpectomy for early-stage breast cancer patients does not affect disease control, survival or complication rates, but administering tamoxifen concurrently with radiation has negative cosmetic results. These find...Genomes of more than 200 human flu strains reveal a dynamic virus
...kind, researchers have determined the full genetic sequence of more than 200 distinct strains of human influen... Until now, the researchers note, most of the gene sequence information available to scientists comprised only relatively short fragments of flu genes that enco...Hopkins geneticist discovers mutations in cancer cells that suggest new forms of treatment
...sing pharmaceuticals. "We picked these proteins to sequence because receptor tyrosine kinases sit on the cell surface where anticancer drugs can get at them," said Gregory J. Riggins, M.D., co-lead author of the study and an associate professor in the Department of Neurosurgery at The Johns Hopkins University...New tools used to control foodborne hepatitis A outbreaks related to green onions
...were slightly different from each other. The viral sequence from each outbreak, however, was identical to one ...anned. "This research highlights the role of viral sequence analysis in improving our overall understanding of the roughly 50 percent of hepatitis A cases in th...Researchers discover how malaria parasite disperses from red blood cells
...d Health and Human Development have determined the sequence in which the malaria parasite disperses from the r... the center of the cell. (A diagram of the entire sequence appears at http://www.nichd.nih.gov/new/releases/malaria_graphic.cfm .) The cell's lop-sided appea...Genetic on-off switches pinpointed in human genome
...enome, scientists have discovered the location and sequence of over 10,000 DNA regions that function as genetic on-off switches, or "promoters" in human fibroblasts. Fibroblasts are relatively generic, easily maintained, human cells that form connective tissues throughout the body. By knowing the specific seq...Study shows how sleep improves memory
...ve healthy, college-aged individuals were taught a sequence of skilled finger movements, similar to playing a piano scale. After a 12- hour period of either wake or sleep, respectively, the subjects were tested on their ability to recall these finger movements while an MRI measured the activity of their brain...Online analytical toolbox for cancer and other biomedical research
...up developed to combine gene information with gene sequence information. The toolbox is detailed in a paper, ..., and patient outcomes as well as gene expression, sequence and gene ontologies. Acharya says the extent of knowledge that can be extracted from any of the ind...Johns Hopkins team finds 'ancestral' hepatitis-C virus at the root of evolution in infections
...researchers to compare changes observed in the RNA sequence to corresponding shifts in the body's immune respo...raise the possibility that a hepatitis-C consensus sequence could be the best practical option for a vaccine," says infectious disease specialist David Thomas, ...New memory drug works best in combination with older remedy
...SGS742 had less CREB2 bound to this important gene sequence than did the rats that had not been treated. "This indicates that SGS742-treated rats had an easier time activating the appropriate genes necessary for memory consolidation," Haberman said. "The fact that SGS742 improved memory even when it was given...Treatment helps in preventing TB among those at high risk
...was 22.1 months. Employees were invited in random sequence to attend a workplace HIV clinic. Isoniazid, 300 mg/d, was self-administered for 6 months among attendees with no evidence of active tuberculosis. A total of 1,016 of 1,655 men included in the analysis attended the clinic at least once. Six hundred s...Drug to block mother-to-child HIV transmission induces resistance more often than previously thought
...ing a less-sensitive conventional technique called sequence analysis, researchers had previously estimated that viral resistance to nevirapine emerged in approximately 40 percent of women after receiving the single-dose therapy. In contrast, Dr. Johnson and colleagues concluded that resistance emerges in at l...Ramelteon demonstrates no abuse potential according to study results
...as administered to patients in a randomly-assigned sequence and included: ramelteon (16 mg, 80 mg, 160 mg); triazolam (0.25 mg, 0.50 mg, 0.75 mg); and, placebo. Measures of "drug-liking," were assessed each day using questionnaires completed at intervals between 0.5 hours pre-dose, up to 24 hours after ...The anatomy of sarcasm: Researchers reveal how the brain handles this complex communication
...hend sarcasm depends upon a carefully orchestrated sequence of complex cognitive skills based in specific parts of the brain. Yeah, right, and I'm the Tooth Fairy. But it's true: New research details an "anatomy of sarcasm" that explains how the mind puts sharp-tongued words into context. The findings app...Breast tumor's biological traits guide hormone therapy
...elp physicians choose the most effective treatment sequence with tamoxifen and the newer aromatase inhibitors, according to a study led by researchers from Dana-Farber Cancer Institute in Boston. The findings (abstract 529) will be presented in a poster session at the American Society of Clinical Oncology's a...Innovative study finds way to 'bio-synthesize' an anti-cancer compound
... found the chemical pathways in the microbe's gene sequence that are responsible for producing patellamide A a...mides in the draft genome. Ravel's group found the sequence for Patellamide A, and after further examination Schmidt's group found the Patellamide C sequence ...