High risk of breast cancer associated with genetic variation in leptin and its receptor
...either of two genetic variations that lead to high serum levels of the cytokine leptin and to overexpression of leptin in fatty tissue, are more at risk of developing breast cancer than others. A study published today in the open access journal BMC Cancer suggests that individuals with a specific genetic v...Cholesterol levels discounted as a biological marker for suicide risk among alcoholics
...hers examine both demographic factors and selected serum lipid concentrations in alcoholic patients. Resul... undetected. We wanted to investigate if elevated serum cholesterol levels could serve to identify these individuals early enough to help them." "Recent stu...Androgen deprivation therapy does not keep localized prostate cancer from spreading, new study says
...articularly those with high Gleason score and high serum PSA," Beer said. "These data will be useful for men with localized prostate cancer choosing between aggressive treatments such as surgery or radiation, observation and androgen deprivation therapy." In an earlier OHSU Cancer Institute study of the ef...Predicting cardiovascular problems in liver transplant patients
...ial blood pressure, height, weight, medication and serum levels of creatinine, total cholesterol, HDL-chole...factors to those previously established, including serum high sensitivity C-reactive protein, fibrinogen, homocysteine, lipoprotein and apolipoproteins A1 an...Conference examines latest research on drug-induced liver injury
... the DILIN in which patients' DNA, lymphocytes and serum is being examined in an attempt to tease out what causes susceptibility to idiosyncratic DILI, so that diagnostic tools can be created that will help identify those patients most at risk. One important component is that all subjects have agreed to lo...Seattle Heart Failure Model is able to accurately predict survival for patients with heart failure
...ables like hemoglobin, cholesterol, uric acid, and serum sodium. The model was derived by examining 1,125 heart failure patients, and validated in five additional groups, totaling 9,942 patients. The accuracy of the model was excellent. "What is unique about this model is that one can estimate the change ...Purdue chemical-analysis method promises fast results
... chemicals normally present in the urine, blood or serum of healthy people. The DESI experiment allows testing to be done without separating the compounds of interest from biological fluids, Cooks said. "For example, we can place a small drop of urine on filter paper and then test the samples, recording a ...UC Davis study shows grape seed extract may be effective in reducing blood pressure
... milligrams of grape seed extract also had reduced serum oxidized LDL cholesterol levels. "Generally, the higher their initial oxidized LDL level was, the greater the drop by the end of the study," he said. The extract has received the GRAS (generally recognized as safe) certification from the FDA and has ...H5N1 avian flu virus vaccine induces immune responses in healthy adults
...a neutralizing antibody response to the vaccine at serum dilutions of 1:40 or greater, whereas only 22 percent of the 100 people evaluated who received the 15-mcg dose developed a similar response to the vaccine. Generally, all dosages of the vaccine appeared to be well tolerated: Almost all reported si...Cinnamon, cloves improve insulin function, lower risk factors for diabetes, cardiovascular disease
...evel of clove supplementation showed a decrease in serum glucose from an average 225 to 150 mg/dL, triglyce...s from an average 235 to 203 mg/dL, a decrease in serum total cholesterol from 273 to 239 mg/dL, and a decrease in LDL from 175 to 145 mg/dL. The individua...Japanese encephalitis widespread in Bali
... the disease the virus was only detected in their serum and not in their cerebrospinal fluid. Of these 90 children, only one was over 10 years old. Of the children with confirmed Japanese encephalitis, nine died and 31 were left with serious neurological disability. The authors conclude that the annual in...Prostate cancer research may be faster with PSA endpoints
...hors observed that the risk of death, in men whose serum PSA levels declined by at least 30 percent in the first three months of treatment, was reduced more than 50 percent. Findings are published in the Journal of the National Cancer Institute (April 19, 2006 issue). "The findings show that PSA levels c...FOSRENOL significantly reduces tablet burden for end-stage renal patients with hyperphosphatemia
...phosphate binder therapies provides continued mean serum phosphorus control for end-stage renal disease (ES...rated every two to three weeks until an acceptable serum phosphate level is reached.) Further, the study found that the doses of FOSRENOL needed to control m...Predicting outcomes for kidney transplant patients
...tly, kidney failure is determined by measuring the serum creatinine, but creatinine is an unreliable indicator during acute kidney injury and does not reflect the degree of damage until a steady state has been reached, which may be several days. Dependable diagnostic testing is currently not available for ...Patients with nonalcoholic fatty liver disease have an increased risk of heart disease
...not have this increased risk. "Given that elevated serum ALT in the absence of viral hepatitis or excessive alcohol consumption is most commonly due to NAFLD in the U.S., our results suggest that NAFLD is associated with an increased risk of coronary heart disease," the authors state. They also evaluated w...A non-invasive method for measuring beta cell mass during diabetes
... as a surrogate measure of beta cell mass. However serum insulin concentrations provide an imprecise measure of beta cell mass, and no reliable non-invasive measure of beta cell mass has been available, until now. In a study appearing online on May 18 in advance of print publication in the June issue of th...No link between short-term testosterone use and prostate cancer, study says
...n older men. However, this study showed that when serum testosterone levels are increased to the mid-norma.... The groups were comparable at baseline for age, serum T and DHT, Prostate-Specific Antigen (PSA), Prostate Volume (PV) and median prostate levels of T and...Biologic therapies lead evolution of Crohn's treatments
...RI and analysis of cerebral spinal fluid (CSF) and serum for JC virus. An independent expert committee reviewed all suspected cases of PML and made final determinations of whether the patient had PML. In addition to patients from clinical trials, four post-marketing reports of suspected PML were also ref...U of MN study finds health education helps African American light smokers kick the habit
...domly taken to check for tobacco-related compounds serum cotinine and carbon monoxide, which, if present, indicated an individual was using tobacco products. Quit rates for participants using nicotine gum were 14.2 percent compared to 11.1 percent for the placebo group. Participants receiving health educat...Calorie restriction appears better than exercise at slowing primary aging
...y CR -- only in the people on CR diets. But their serum concentrations of two other hormones -- thyroxin (...sm. Interestingly, body fat levels did not affect serum T3 concentrations. The people in the CR group and the endurance athletes had similar amounts and com...