Cancer drug side effect caused by cell 'pump' problem
...drugs. The mutation, a type of alteration called a single nucleotide polymorphism, is designated 421C>A in reference to the specific change in one of the DNA building blocks of the gene. ABCG2 pushes drugs out of cells and back into the blood, or in the case of the liver, the pump pushes drugs into...Researchers suggest new direction for development of psychotropic drugs
...cal setting, we won't fully know the usefulness of single target treatments," added Husseini Manji, MD, FRCPC, Chief, NIMH Laboratory of Molecular Pathophysiology. The most promising new direction for CNS (central nervous system) drug development appears to be focusing on treatments that act on more than o...OHSU findings may improve how people with chronic heartburn, precancer of the esophagus are screened
...ison, the skinny scope procedure is performed by a single clinician in an office setting and does not require sedation. Patients inhale a topical anesthetic that numbs their nasal passages and throat. The clinician then passes a smaller-caliber endoscope, 4.9 mm in diameter, through the nose, pharynx and th...Math model predicts cancer behavior
...has fingering, invasive projections. By changing a single condition oxygen concentration the investigators can modulate the tumor's degree of invasiveness, Quaranta said. The findings suggest that current chemotherapy approaches which create a harsh microenvironment in the tumor may leave behind the most ...The pain from fibromyalgia is real, researchers say
... functional magnetic resonance imaging (fMRI) and single photon emission computed tomography (SPECT) indicate there is a difference between patients with and without fibromyalgia. In people without pain, these structures encode pain sensations normally. In people with fibromyalgia, the neural activity in...Autoimmune disease triggered if T cells miss a single protein early on
... body's antigens is not recognized as "self," this single failure can lead to a severe autoimmune disease in...dy proteins or antigens since we have shown that a single self-antigen can trigger disease," he added. A similar mechanism may be at play involving other aut...Policy makers, networking agencies told to get their act together for nanoscience
...of Modena, Italy, noted that there is currently no single institution in charge of this research area and Europe will need about 300,000 to 400,000 personnel in the field between 2010 to 2015 while 2 million will be needed on a global scale. "I think we need to have nanomedical education and we need comm...Mayo Clinic ranked first in 2006 National Health Care Quality and Accountability
...., CEO of Mayo Clinic Rochester. "Quality is not a single element in patient care but rather a combination of many factors combined with a clear focus on each patient's needs. Quality health care requires daily attention to detail and a collaborative team to make it a reality. We are fortunate to have physi...Breast cancer drug receives FDA approval
...ame chemotherapy without Herceptin. "In terms of a single leap forward, this is probably the most dramatic we've had in a long time," Romond said. The study revealed the use of Herceptin in early-stage HER-2 positive breast cancer was effective. Herceptin was previously only used in late-stage breast cancer...Fosrenol data show evidence of trends towards improved bone formation in CKD stage 5 patients
...rating that most patients can be controlled with a single 1 g tablet per meal. (Dosing based on three meals per day. Number of meals per day may vary. To achieve certain doses, additional tablets may be required.) Of the 367 patients enrolled, 274 (75 percent) completed the study. Mean serum phosphoru...Ultrasound mammography, volcano monitoring for aircraft safety
...ll remember the first impression of the sound as a single loud noise. In short order, however, different sounds begin to emerge as one listens to a few speakers, hears the melody from the band, or even focuses upon one instrument. According to University of Maryland researcher Shihab Shamma ( sas@eng.umd.ed...ResearchChannel reveals the research environment of the future
...data points that are nearly impossible to see on a single computer screen. A variety of visualizations will demonstrate the utility of these ultra-resolution environments for analyzing large and visually complex data sets, such as co-authorship, citation and time-series social networks. "The technologies...RAND study finds vaccination of nursing home staff, residents, key to reducing flu outbreak
...urveyed more than 340 nursing homes belonging to a single nursing home corporation with facilities located across the United States. Ninety percent responded, for a final sample size of 301 nursing homes. The facilities ranged in size from 34 beds to 355. Vaccination status was self-reported and not verifie...Elderly, ill men get unneeded prostate cancer screenings
... dying within a year were given the test. "Not a single professional organization, physicians' group, or p...ry. Married men were more likely to be tested than single men. The higher the income a man had, the more likely he was to be tested. Paradoxically, African-Am...Specific strategic plans ensure timely emergency care for heart attack patients
... activate the catheterization laboratory, having a single call to a central page operator activate the laboratory, having the emergency department activate the catheterization laboratory while the patient is en route to the hospital, expecting staff to arrive in the catheterization laboratory within 20 minu...Inexpensive test detects H5N1 infections quickly and accurately
...veloped an inexpensive "gene chip" test based on a single influenza virus gene that could allow scientists t...tage over available tests because it is based on a single gene segment that mutates less often than the flu genes typically used in diagnostic tests. As a res...Maximizing womens' health benefits when resources are limited
...nnual health budget of the poorest countries and a single health check per woman in the two decades followin...the packaging of multiple health services during a single visit has great potential to maximize health gains, provided the right interventions are chosen. The...Fast test for low blood flow in dogs detects early heart trouble
...hine costs between $1.5 million and $2 million. A single test costs approximately $700....To slow AIDS in Russia, treat HIV-positive addicts, Stanford study says
...fect of two or three medicines works better than a single one to keep the virus at bay. Antiretroviral therapies have the added benefit of reducing the chances that an infected person will transmit HIV to others. To understand how antiretroviral therapy could affect HIV transmission in Russia, Owens and Br...Newest in CT imaging technology -- dual energy source -- now being utilized on patients at Penn
... obtain diverse information about the anatomy in a single scan. Radiologists utilize these images to search for narrowing or blockages in the coronary arteries of the heart. Litt continues, "We can use these images to figure out the cause when patients are complaining of chest pain. Specifically, we may ...