Technique may speed drug production, reduce costs and waste
...lling drugs, there are often hundreds of litres of solvent used, not to mention the many purification processes involved. Not only are you speeding up the process, you're also reducing waste and energy used in manufacturing." A provisional patent was filed by U of T's Innovations Foundation in March. The res...Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
...group of control mice received an injection of the solvent used to carry the drugs. The investigators then injected each mouse with NMDA, a drug that stimulates the NMDA receptor. Excessive stimulation of these receptors by NMDA, such as during stroke, leads to nerve cell damage. In mice that had first rece...Genes and environment interact to promote cancer
...n 2004, Duke researchers showed that an industrial solvent (EGME) and a commonly prescribed drug, Valproic acid, potently boosted estrogen and progestin activity inside cells. The elevated hormone levels are likely responsible for the reproductive failures and breast cancers seen among women exposed to these...New analytical techniques developed to quantify composition of fake anti-malarials
...pray containing alcohol and water. Typically, this solvent mixture reacts with a solid sample, such as a tablet, picking up molecules from its surface and transferring them to a detector. But artesunate is a relatively unstable molecule that fragments easily and causes DESI to lose its sensitivity. So Ferna...Sandia work launched on space shuttle shows live cells influence growth of nanostructures
...a cell, researchers use time-consuming fixation or solvent extraction techniques," says Brinker. "We can spin-coat a cell in seconds, pop the cell into an electron microscope, and it doesn't shrink when air is evacuated from the microscope chamber." The cell can be immediately imaged, says Brinker. "Spin-c...Obesity in men linked to infertility
...woman, age, cigarette smoking, alcohol intake, and solvent and pesticide exposure. After adjustment, there was a general increase in infertility with increased BMI, reaching a nearly 2-fold increase among obese men. When researchers divided the sample into two equal groups by men's age, they found that ...BC catalyst discovery promises faster, cheaper drug production
...catalyst is easy to prepare, requires little or no solvent and therefore minimizes waste, and can be used in air and can be recycled several times," Prof. Snapper added. "Together, these properties make our discovery an important one both from the theoretical as well as the practical point of view." "This i...Solvent exposure linked to birth defects in babies of male painters
...to evaluate and compare the influence of resulting solvent exposures on reproductive health," said Dr. Bursty... showing that water-based paints did not eliminate solvent exposure among construction painters. Organic solvents are widely used in many industries includin......nto the mass spectrometer, the droplets lose their solvent and continuously fragment until nothing is left but the charged molecules, which then proceed into the QTOF mass spectrometer. This allows the analysis to be carried out continuously over longer periods of time so that larger samples can be examined.......spheres is very uniform and depends largely on the solvent in which the linking reaction takes place. The researchers used this method to produce capsules with diameters ranging from 50 to 600 nm. The little disks used in this process deserve special consideration: Kim and his colleagues chose to use curcur...Students devise oral quick-dissolve strips for rotavirus vaccine
...ocess used to make breath strips because the harsh solvent and high temperatures used would destroy the vaccine. They also had to devise a protective coating that would remain intact when exposed to stomach acid but would dissolve in the chemically neutral environment of the small intestine. Through ext...New mangosteen research establishes xanthone measurement standard
...e purified by preparative HPLC, utilizing the same solvent system and UV detection as for the analytical method, said Walker. Each compound has unique UV absorption spectra that allows for easy identification of the xanthone found naturally in the mangosteen fruit." Research lab ChromaDex developed the stan......at the folic acid attachments project out into the solvent and are readily available for binding to cells, whereas the dye molecules stay far removed from the metal nanoparticles and thus retain their bright fluorescence. Many cancer cells, including those implicated in cancers of the ovary, kidney, uterus,...Scientists train nano-'building blocks' to take on new shapes, as reported in Science
...hnique relied on divalent organic counter ions and solvent mixtures to drive the organization of the block copolymers down specific pathways into snake-like, one-dimensional structures. Much of the research was conducted using the high-powered microscopes in the UD College of Engineering's W. M. Keck Elect...