Simmer to receive research in Biological Mineralization Award
...e made significant observations on the alternative splicing of amelogenin RNA transcripts, and he expressed and characterized recombinant amelogenin (AMELX) protein. In later years, his work revolved around the evolution of enamel proteins. These basic science advances led directly to improvements in our unde...Key to lung cancer chemo resistance revealed
...uggesting other ways of dismantling KEAP1, such as splicing the gene to make a shortened, ineffective protein, he said. The researchers plan to confirm their findings with a larger set of samples and then to screen for appropriate drugs. Funding for the study was provided by the National Cancer Institute...Newly discovered behavior in cancer cells signals dangerous metastasis
... genetic copying program inside cells. Alternative splicing determines how the DNA is chopped into pieces and ... proteins the gene produces. In cancer cells, the splicing machinery goes awry -- as do myriad functions within the cells. When the splicing process proceeds o......ory occur. Researchers have long agreed that mRNA splicing takes place within the cell nucleus. In the nucleu...r proteins) and introns (non-coding regions). mRNA splicing works by cutting out introns and merging together the remaining exon pieces, resulting in an mRNA ca...