New strategy improves outcome for children with most common type of brain tumor
...e of chemotherapy, and a reinfusion of bone-marrow stem cells after each cycle of chemotherapy. Children with high-risk medulloblastoma have a 3040% chance of surviving to 5 years, and chemotherapy usually lasts for about 12 months. By using their risk-adapted approach to radiotherapy, Dr Gajjar and co...Combined therapies may boost immune response and long-term protection against brain tumors
...he researchers injected bone marrow-derived neural stem cells that were genetically engineered to produce IL-23. The stem cells tracked tumor cells and the IL-23 produced an immune response and long-term protection. In th...Scripps research team reverses Friedreich's ataxia defect in cell culture
...y too toxic for therapeutic use. Gene therapies or stem cell treatments may eventually be available to increase frataxin production, but such options are probably many years off. "Our small molecules offer a therapeutic approach to pursue in the near term," said Gottesfeld. ...New method shows that neocortical nerve cells are not renewed
...nreliable and controversial results. Last year, stem cell researcher Jonas Frisn from Karolinska Institutet presented a way to settle the issue with help from unexpected quarters the nuclear tests of the cold war. He used a variation on the well-known carbon-14 method that is based on the fact that at...Kids need more time than adults give them, study finds
...eir difficulties with eyewitness testimony may not stem from memory errors alone but may arise due to difficulty in perceiving some critical aspects of a scene in the first place. "We expect children to be adult-like, because of their proficiency on computers or because they display adult-like speech,...New hope in cancer vaccines emerges as novel therapies are developed and tested
... with multiple myeloma who are slated to receive a stem cell transplant from a matched donor. In this st... which will also be tested in patients at the NIH, stem cell donors will be vaccinated with the patient's tumor antigen. "The donor has a healthy immune sy...Irrational decisions driven by emotions
...The UCL study suggests that rational behaviour may stem from an ability to override automatic emotional responses, rather than an absence of emotion per se. It has long been assumed in classical theories of economics that people act entirely rationally when taking decisions. However, it has increasingl...Deployment to Iraq war associated with increased risk for adverse neuropsychological effects
...al health remain poorly understood. Knowledge gaps stem largely from a lack of predeployment health information and assessments conducted too long after war-zone exposure. Jennifer J. Vasterling, Ph.D., of the Southeast Louisiana Veterans Health Care System and Tulane University School of Medicine, New ...Discovery in 'Bubble Boy' disease gene therapy
...ers inserted normal gamma C genes into bone marrow stem cells removed from young children with the disease...e clinicians then infused the genetically modified stem cells back into the patients, restoring the ability of nine children to develop full immune systems....Malignant melanoma cells secrete protein required for embryo formation
...ls toward a normal skin cell type. Like embryonic stem cells, malignant tumor cells similarly receive and...tic" nature, which is similar to that of embryonic stem cells, expressing genes characteristic of multiple cell types, including endothelial, neural and ste...New genetic model for Parkinson's disease
...at the dopamine producing nerve cells in the brain stem slowly degenerate", says Dr. Nils-Gran Larsson. "In the microscope we can seethat the mitochondria are swollen and that aggregates of a protein, probably alpha-synuclein starts to accumulate in the nerve cell bodies. Inclusions of alpha-synuclein-ric...Message to older adults: embrace, don't fear the effects of sensible exercise
...es a week. Researchers say that people's concerns stem from the fact that during each workout, blood pressure can on average rise from 40 millimeters to 60 millimeters of mercury. The Hopkins study is believed to be the first to evaluate the effects of exercise on the heart's ability to function, to pum...Mass. General study finds potential ovarian cancer stem cells
...searchers have identified potential ovarian cancer stem cells, which may be behind the difficulty of treat...populations of tumor cells that appear to act like stem cells, driving the tumor's ability to grow and spread. If some of these specialized cells escaped d...JCI table of contents: July 3, 2006
...-jci.org/article.php?id=29148 CARDIOLOGY Cardiac stem cell therapy boosts blood vessel growth and injury...sted that injection or mobilization of bone marrow stem cells into injured heart muscle during or after myocardial infarction would be able to regenerate he...Novel gene therapy may lead to cure in hemophilia A patients
...readily in plasma, we inserted a gene into a blood stem cell so that FVIII is produced and stored in blood...rials can begin in patients. Blood and bone marrow stem cells would be harvested from hemophilia patients in much the same way they are collected from bone ...Healing the heart with bone marrow cells
...the critically important role of bone marrow adult stem cells in repairing a damaged heart, restoring its ...d heart. By binding to another molecule called the stem cell factor much like a lock and key -- the "turned on" c-kit activates the bone marrow cells to m...Dental stem cells have been characterized for tooth tissue engineering
...thods were used to generate enriched clonal dental stem cell (DSC) lines. Expanded DSC and non-DSC lines ...he-art craniofacial tissue engineering efforts via stem cells. This work was supported by the Center for Integrated Medicine and Innovative Technology (CIM...Refined stem cell therapy helps paralyzed rats recover
A therapy that combines differentiated stem cells with myelin inhibitors and a motor axon trop...ournal/ana ). Scientists' ability to differentiate stem cells toward specific mature cell lineages is assisting in the study of diseases and the development...Hopkins scientists use embryonic stem cells, new cues to awaken latent motor nerve repair
In a dramatic display of stem cells' potential for healing, a team of Johns Hopk...t animals. The research, in which mouse embryonic stem (ES) cells were injected into rats whose virus-damaged spinal cords model nerve disease, shows that ...Stanford doctors advance in bid to turn mice stem cells into blood vessels
...ken a first step toward growing blood vessels from stem cells that could eventually be transplanted into living organisms. Starting with embryonic stem cells derived from mice, surgical resident Oscar Abilez, MD, and colleagues have successfully differ...