'Fickle' enzyme helps protect, but also can promote heart failure, animal study shows
...ng enzymes, nitric-oxide synthase-3 (NOS3). NOS3 stops functioning normally when levels of its cofactor, called tetrahydrobiopterin (BH4), decrease. Results not only showed that BH4 levels drop in hypertrophied hearts, but also that NOS3 uncouples, or splits apart, in the absence of its cofactor. Less N...Moderate to severe sleep apnea significantly raises stroke risk, study finds
...lly collapses, during sleep. As a result, a person stops breathing briefly multiple times throughout the ni...aid. Another possible reason is that when a person stops breathing, the lack of oxygen kicks in the body's "fight or flight" response. Part of that reaction ...Post-marketing analysis examines cholesterol-lowering drugs' side effects
...e effects, they generally go away when the patient stops taking the drug. As reported in Circulation: Journal of the American Heart Association, the researchers analyzed adverse events reports (AERS) sent to the U.S. Food and Drug Administration for rosuvastatin and compared them to AERS rates during the s...Despite alternatives, addictive drugs most often prescribed for sleep problems
...experience severe withdrawal-like symptoms once he stops taking the medication," he said. Office visits by people 50 and older were about 5 times as likely to result in a drug treatment for sleep problems as were visits by 18- to 34-year-olds. And people 65 and older were twice as likely as the 18- to 34-y...University of Maryland scientist wins 2005 Kettering Prize
... the standard breast cancer drug, tamoxifen, which stops working after five years. Samuel A. Wells, Jr., M.D., president of the General Motors Cancer Research Awards, says that Dr. Brodie was chosen to receive the 2005 Charles F. Kettering Prize after a "very rigorous selection process" by top scient...Arteries bio-engineered from elderly cells
...subunit) component of the enzyme telomerase, which stops telomeres from shortening. He showed that expression of hTERT permitted some human cells to continue to divide indefinitely, in effect making them immortal. Using arterial cells from a two-year-old child, the Duke team reported in 2003 that when the ...UCI researchers create method for predicting most effective use of cancer-fighting drugs
...hese mutant cells become a problem and the therapy stops being effective. The finding will help physicians determine when a combination of drugs will be more effective in fighting a cancer. Researchers Natalia Komarova and Dominik Wodarz present their findings in this week's online edition of the Proceedi...Potent spice works to block growth of melanoma in lab test
...EDT) on Monday, July 11, demonstrates how curcumin stops laboratory strains of melanoma from proliferating and pushes the cancer cells to commit suicide. It does this, researchers say, by shutting down nuclear factor-kappa B (NF-kB), a powerful protein known to promote an abnormal inflammatory response tha...Study shows new imaging tracer clarifies cause of chest pain up to 30 hours after pain stops
... a common cause of chest pain, long after the pain stops and blood flow to the heart returns to normal," says lead investigator Vasken Dilsizian, M.D., professor of medicine and diagnostic radiology and nuclear medicine at the University of Maryland School of Medicine and director of Cardiovascular Nuclear...NASH clinical research network launches trial for treatment of liver disease in children
...ecomes so damaged from scarring that it completely stops functioning, a liver transplant is necessary. Researchers are concerned that the disease may progress in children and increase their risk for cirrhosis, liver failure, and death as adults, particularly if they drink alcohol or contract viral hepatiti...Long-term smoking is associated with up to 40 percent increased risk of breast cancer
...ng and encouraging finding was that once a woman stops smoking, within about 10 years of quitting her risk of breast cancer falls back to that of a never-smoker. This suggests that recency of smoking may be particularly important with respect to breast-cancer risk, Li said. "We know that smoking is asso...Annual report to the nation finds cancer death rates still on the decline
...ortunities so we must continue to pull out all the stops to ensure proper screening and access to treatment regardless of one's age, race, or geographic location." For breast cancer, data on trends in the treatment of early-stage disease show that the proportion of women diagnosed with stage I or II (earl...Innovative gel reduces post-operative pain
...ofessor of otolaryngology at Rush. "It effectively stops the bleeding and may advance the healing process." The plasma gel replaces temporary sponges or sterile packing at the surgical site which, according to Dutton, can be uncomfortable, painful and may restrict breathing. Unlike the traditional material...Enzyme complex thought to promote cancer development can also help prevent it
... the researchers developed a "mutant" protein that stops EZH2 from being phosphorylated, and they say this molecule might provide the basis for either a small-molecule drug or a gene therapy treatment, Hung says. Indeed, in their study, the research team used the agent to reduce tumor growth in a mouse mod...Growth hormone illegal for off-label anti-aging use, study warns
...ng clinics market HGH with claims that the hormone stops and reverses aging and provides many other benefit...hough there is no evidence that HGH administration stops or reverses aging, many people spend a great deal of money on these products," Perls said. "On the c...Successful tests of new treatments in mice for eye disease causing irreversible blindness in humans
...set of these diseases, it is known that the retina stops functioning due to loss of the lecithin retinol acyl-transferase enzyme (LRAT). LRAT is required for regeneration of a pigment necessary for the eye to detect light. LCA can be caused by mutations in the gene encoding RPE65, a key protein involved i...Heart mapping technique safely guides catheter repair of arrhythmia
...erform cardiac ablation, a mainstay treatment that stops abnormally fast and potentially fatal heartbeats, or arrhythmias. The Hopkins findings, to be presented at the American Heart Association's Scientific Sessions 2005 on Nov. 13 in Dallas, Texas, provided information and technology used by the United...UC Davis researchers discover genetic switch involved in cells' response to radiation therapy
...during transcription and replication. Camptothecin stops DNA topoisomerase I during the unwinding process, ultimately killing the cell....'No sweat' CT-guided injection treats embarrassing hand condition
...s technique is the most secure treatment today and stops sweating from the hands to the armpits with very little chance of recurrence," said the study's lead author, Hugues Brat, M.D., head of the radiology department at Centre Hospitalier Hornu - Frameries, in Hornu, Belgium. Up to three out of every 100 ...... North America (RSNA). "This treatment immediately stops blood flow in the fibroid tissue, which results in a significant, sustained decrease in symptoms for up to 12 months," said the study's lead author, Fiona M. Fennessy, M.D., Ph.D., instructor of radiology at Harvard Medical School and staff radiologi...