Antibody combined with cancer drug shows promise against breast tumors
...aid. In mice with breast cancer tumors, growth was suppressed by 50 percent using 3G4 alone and 70 percent for docetaxal alone. The reduction in lung tumor colonies was 82 percent with 3G4 alone and 78 percent with docetaxal alone. Peregrine Pharmaceuticals is developing a version of 3G4 called Tarvacin for can...Nutrition gene key in regulating immune system
...ust were never activated, or if they were actively suppressed by IDO. They all look like resting T cells. Now we do know that there are differences." MCG researchers want to know more about how GCN2 puts T cells to sleep. "Whatever it's doing doesn't appear to be killing the T cells. It would be nice to be able...Other highlights in the May 18 JNCI
... apoptosome-mediated cell death in tumor cells and suppressed the growth of lung tumors in a mouse model. The authors conclude that acyl-CoA synthetase inhibition may be a novel strategy to induce p53-defective tumor cell death. Contact: Tetsuo Mashima, Japanese Foundation for Cancer Research, 81-3-3520-0111, ...Enhancing innate immunity improves Crohn's disease symptoms
... macrophages, not the T cells and B cells that are suppressed by other Crohn's disease therapies." The strategy appears to help a significant number of patients. In 2002, Korzenik and Dieckgraefe published results from a preliminary15-patient, open-label study in The Lancet reporting that GM-CSF treatment imp......wed that phytochemicals in this popular snack food suppressed the growth of oral bacteria associated with caries and gum disease," said Christine Wu, professor and associate dean for research at the UIC College of Dentistry and lead author of the study. Phytochemicals are compounds found in higher plants. The d...USC researchers link cellular stress to drug resistance in tumors
...showed that tumor cells in which the GRP78 gene is suppressed are unable to mount a resistance to the chemotherapy drug etoposide. "Our studies imply that anti-vascular and anti-angiogenesis therapy that results in severe glucose and oxygen deprivation will induce GRP78 expression that could lead to drug resist...Treatments for prostate cancer may affect employment
...se would have quit to keep working, which may have suppressed unemployment numbers. Additionally, those still working had decreased their weekly hours work by 4 hours on average, and 43% of them attributed their inability to work at their former capacity to cancer treatment-related symptoms. After 12 months, t...Potent spice works to block growth of melanoma in lab test
...sed, says the researchers. "The NF-kB machinery is suppressed by both short exposures to high concentrations of curcumin as well as by longer exposure to lower concentrations of curcumin," they say in their study. Given that other studies have shown curcumin is non-toxic, these results should be followed by a t...Mouse studies of oseltamivir show promise against H5N1 influenza virus
...mivir for five days survived. Although oseltamivir suppressed the virus in the mice, the virus continued to grow if the drug was stopped after five days. Mice given the drug for eight days fared better. Survivors included one of 10 mice given the lowest daily dose, six of 10 given the middle-range daily dose, a...Other highlights in the July 20 JNCI
...y during the dark phase of the lightdark cycle--is suppressed by exposure to light during the night. Studies of night-shift workers have found an association between night-shift work (a surrogate for light exposure at night) and an increased risk of breast cancer, but the association between melatonin levels an...HIV therapy success rates similar in developing and developed world, study shows
...ies. The general success rate in keeping the virus suppressed after being on the program for 12 to 18 months is about 60 per cent. The results are published this month in the journal Clinical Infectious Diseases. Doucette said she was not surprised with the results, except for the fact that people in developing...Rats' response to 'stop snacking' signal diminished by high fat diet
...ormone, the rats on the low fat diet significantly suppressed their intake of the snack but not the rats on the high fat diet." Covasa adds, "These results suggest that a long-term, high-fat diet may actually promote short-term overconsumption of highly palatable foods high in dietary fat by reducing sensitivi...Marijuana-derived drug suppresses bladder overactivity and irritation in animal models
...ubacute bladder inflammation. IP 751 significantly suppressed bladder overactivity in both animal models without affecting bladder contractility. By doing this, IP 751 can ease bladder pain. By stopping the underlying cause of irritation - overactivity of the bladder - IP 751 is able to eliminate the associated...Suppression of FOXO1a gene might kill resistant ARMS tumors
.... Jude team found that the expression of FOXO1a is suppressed in ARMS and that the gene potently suppresses tumor activity when re-introduced into ARMS tumor cells in the laboratory. Therefore, the investigators theorize that the observed loss of FOXO1a activity is a pivotal step in the ARMS development. The FO...Researchers pinpoint molecular basis for phantom pain
...ns in the thalamic region of the brain that can be suppressed with specially designed molecular agents. "A majority of people with spinal cord injury and limb amputations experience phantom sensations of excruciating pain at or below the level of their paralysis or loss," said Bryan Hains, associate research s...Kidney transplant patients face higher cancer risk
...raviolet radiation, commonly caused by sunburns, a suppressed immune system, and family history of abnormal moles. Studies demonstrate that the immune system plays a critical role in monitoring the body for and destroying early cancerous cells, including melanoma. Patients taking immunosuppressants after orga...Kidney transplant patients face higher skin cancer risk
...raviolet radiation, commonly caused by sunburns, a suppressed immune system, and family history of abnormal moles. Studies demonstrate that the immune system plays a critical role in monitoring the body for-and destroying-early cancerous cells, including melanoma. Prior studies have shown that patients taking i...Penn study finds direct role for glial cells in brain cross-talk
... When adenosine accumulated, nerve impulses were suppressed and could not be transmitted across the synapse. This helps explain why high adenosine levels can suppress epileptic seizures. In contrast, low levels of adenosine increased the transmission of nerve impulses. The modulation of neuronal activity th...Curcumin halts spread of breast cancer in mice
...tory response, triggering metastasis, and curcumin suppressed it, causing cell death. Extracted from the roots of the curcuma longa plant, curcumin is a member of the ginger family. While it is not used in conventional medicine, it is widely prescribed in Indian medicine as a potent remedy for liver disorders, ...Infertility researchers identify one gene's critical role in the human embryo implantation process
...sterone was present without estrogen, the gene was suppressed and the endometrium would not be receptive to implantation. "Our next step," says Kao, "will be to explore other regulatory mechanisms or other chemicals - instead of hormones - that might provide us with a more specific approach to modulate this gen...