Hopkins geneticist discovers mutations in cancer cells that suggest new forms of treatment
... because receptor tyrosine kinases sit on the cell surface where anticancer drugs can get at them," said Gregory J. Riggins, M.D., co-lead author of the study and an associate professor in the Department of Neurosurgery at The Johns Hopkins University School of Medicine. In the study, published in the Octobe...1.7m to build world's first SIMS instrument combined with infra-red spectroscopy
...iculate pollutants. The new instrument will enable surface and bulk analysis to be carried out simultaneously by combining SIMS surface analysis with infrared spectroscopy. The project, which will span a four year period, is funded by t...New immune cell found to be a key to inflammatory diseases
...e invaders that already have been displayed on the surface of other immune system cells. (These T helper cells are also called CD4 T cells since they express CD4 molecules.) Once the antigen has been bound, these T helper cells become activated, and they morph into "effector" cells which then boost an immune...Synthetic protein eases arthritis symptoms in mice
...(NIH). The protein prevents the assembly of a cell surface receptor, thus blocking transmission of chemical s...s showed that in ALPS a form of PLAD blocks a cell surface receptor and prevents a needed chemical signaling pathway from functioning correctly. In ALPS, the s...The ACCP strives to close the 10/90 gap between rich and poor nations
...electronic access to ACCP publications in place of surface mailing print copies. Chair of the recently established International Development Committee, Barbara Ameer states the working goal of the group is "to strengthen the capacity of clinical pharmacologists worldwide in pursuit of the College's missi...Genomes of more than 200 human flu strains reveal a dynamic virus
...nts of flu genes that encode two of the virus' key surface proteins, hemagglutinin (H) and neuraminidase (N). In collaboration with David Lipman, M.D., and colleagues at NCBI, NIAID will rapidly make this sequence information publicly available through GenBank, an international, searchable online database. T...Large sinus tumors can be removed endoscopically, study finds
...the sinuses between the eyes. They can go over the surface of the eye socket, go up to the skull base. It's a slow-growing tumor but it's a destructive tumor." Patients may complain of nasal obstruction, or primary care physicians may notice the growths on annual exams. Once found, a computerized tomography ...Researchers find multiple proteins that stick to medical devices
...w the adsorption of multiple blood proteins on the surface of a biomaterial over time. "Traditionally, most studies were limited to the 'big three' proteins in blood - albumin, fibrinogen and IgG", Elbert said. The results were published in the Oct. 1, 2005 issue of the Journal of Biomedical Materials Rese...Aussie blokes dying for a health policy, say UWS men's health experts
...th much more closely, to see what lies beneath the surface before we go about trying to fix things." The experts say this will only come through increasing expenditure on specific men's health programs and developing men's health policies. "Australian men are virtually dying for a national health policy. S...Heart failure patients have impaired cooling response, UT Southwestern researchers find
...S Oct. 11, 2005 Reduced blood flow to the skin's surface may be a key cause of heat-related illnesses in patients with congestive heart failure, UT Southwestern Medical Center researchers have found. The first study to investigate how heat affects people with heart failure shows that one of two ways the bo...Immune therapy could treat leukemias, autoimmune diseases, transplant rejection
...rgeting a protein called CD19 that is found on the surface of B cells. As their experimental animal models, they used mice that had been genetically altered to produce a human version of the CD19 protein on their B cells. Their studies demonstrated that CD19 mAbs did tag B cells containing that protein, and...Therapeutic vaccine for ovarian cancer in clinical trials
...n by the immune system as the proteins on the cell surface are seen to be 'self proteins'. Prima's technolog...onse against a protein called mucin-1 found on the surface of ovarian cancer cells and those of other types of cancer. Prima is trialling one of its three prop...Subtypes of ependymomas arise from rare stem cells in the nervous system
...er Cell.RGCs are unspecialized cells that line the surface of the ventricles (fluid-filled spaces in the brain) and the spinal cord, and give rise to normal mature cells in the nervous system. The St. Jude study found strong evidence that when rare populations of RGCs acquire mutations that disrupt the cell ...Military funds research on how nicotine impairs bone healing
...urotransmitter, like a lock receives a key, on the surface of the nerve cell receiving the signal. As part of...oline, nACHRs must transfer signals from the outer surface of the cells they occur on to their inner compartments. nACHRs can do this because they form gateway...In a crisis, creating DNA vaccine could help save lives, slow spread of 'bird flu'
... the construction plans for a protein on the outer surface of the H5N1 virus. When that DNA is injected into cells, it would quickly reproduce the protein and trigger immunization in much the same way as a conventional vaccine. In contrast, producing conventional vaccines from viruses incubated in fertilized...Inhaled nitric oxide may help sickle cell disease
...moglobin releases its oxygen to the tissues. Those surface irregularities create unfortunate puzzle pieces that help hemoglobin S molecules fit together to form the polymer. The neutral charge permits this abnormal bonding that eventually deforms the red blood cells that carry them, Dr. Head says. "As the po...Lipids play important role in nervous system development
...f the protein that helps the lipid get to the cell surface so it can help axons grow, says Dr. Wen-Cheng Xion...leagues found the lipid is transferred to the cell surface at just the right time and place by phosphatidylinositol transfer protein-α, which humans also h...Tracking desertification with satellites highlighted at UNCCD COP
With a quarter of the Earth's land surface affected, the United Nations Convention to Combat ...ight relevant land use change along with increased surface reflectivity, temperature, dryness and dustiness. Infrared sensors can detect vegetation stress due ...Sandia researchers determine that common anthrax sampling methods need improvement
...tical evaluation of current swab, wipe, and vacuum surface sample collection methods. The investigation was i...bbing technique, 125 spores must be present on the surface to obtain a positive culture. Five hundred spores must exist before a positive culture is observed i......d generic medications. "We have only scratched the surface in taking advantage of the money-saving potential of clinically sound generic drugs," said Steve Miller, MD, Express Scripts Vice President, Research, and a study author. "As additional generics come to market and the use of prescription drugs grow...