Stanford study reveals protein's Jekyll-and-Hyde role in cancer growth
...iko Yokoyama, a postdoctoral scholar in pathology, suspected that MLL was somehow deactivating menin's suppressive powers. They tested the theory with mouse cells in vitro by introducing the mutated MLL oncoprotein and letting leukemia begin to thrive. Yokoyama then genetically removed menin from the cancer ce...Cochrane Library publishes the most thorough survey of MMR vaccination data
...such as triggering Crohn's disease or autism, were suspected on the basis of unreliable evidence," says lead author Dr Vittorio Demicheli who works at Servizo Sovrazonale di Epidemiologia, Alessandria, Italy. These findings will be published on 19 October, 2005 in The Cochrane Library. "Public health decisions...Even very low levels of environmental toxins can damage health
...t exposure to widespread toxins that have known or suspected serious potential health effects," say Wigle and Lanphear....Early life stress can lead to memory loss and cognitive decline in middle age
...as revealed by UNESCO last year. While it has been suspected that early life stress can lead to later cognitive impairment, it is not yet possible to affirm this suspicion in human studies, because children's genetic background or other confounders make these analyses too complex. The current study allows inv...Breast cancer increases while experts disagree on causes - Debate in crisis say academics
...er, and it being impossible to ask questions about suspected environmental hazards. Even the epidemiological studies that have been done may have been misfocussed. One research scientist interviewed said, "All the big, solid epidemiology studies we've got have allbeen done on blood and they don't show any asso...Study proves genetic variations influence cystic fibrosis' severity
...dings appear to exonerate certain other previously suspected mutations. Besides Drumm and Knowles, authors of the report include Drs. Fred A. Wright and Fei Zou, associate professor and assistant professor of biostatistics, respectively, at the UNC School of Public Health, and, at Case, Drs. Mark D. Schluchter...Brenner Children's Hospital pediatrician says one symptom no longer a clear sign of child abuse
... in many ways from the children we were seeing for suspected sexual abuse who did not have warts." Sinal and he...t), however the physician treating the child never suspected or reported child abuse. "This is the same virus in a different location in the body and child abuse...New immune cell found to be a key to inflammatory diseases
... already linked to an immune system gone awry. "We suspected that IL-17 is a player in autoimmune and inflammatory diseases, but we didn't understand where IL-17 came from before this finding," says the study's lead investigator, Chen Dong, Ph.D., an associate professor in the Department of Immunology. "Now we...Research offers new approach to developing treatments for cocaine and amphetamine addiction
...s were absent from the brain. CART peptides were suspected to play a role in cocaine and amphetamine drug addiction more than 10 years ago after Dr. Couceyro and colleagues discovered the gene for these neuropeptides. Cocaine and amphetamine were found to increase CART gene activity within a brain area assoc...How can physicians assist in the investigation of bioterrorism or other biocrimes?
...ics and outlines how physicians should: Report a suspected biocrime Collect forensic evidence that can assist the investigation (the process is analogous to the way in which physicians collect and preserve evidence when they treat a patient who has been the victim of a sexual assault) Document details of t...Post-stroke tests not used often enough, especially in women
...itted to the hospital with a confirmed or strongly suspected diagnosis of ischemic stroke -- eliminating the possibility that the difference in testing was due to differences in diagnosis. In all 57 percent of men and 48 percent of women had either a trans-thoracic echocardiogram (called a TTE for short) or a...Psychologists find more sensitive tests for predicting Alzheimer's as well as changes in cognition
... They looked for information-processing breakdowns suspected to happen early in the disease, before the appearance of language and visuospatial problems. Problems with attention, the authors say, could "underlie the difficulty with daily activities often seen in the early stages of the disease." Duchek and Ba...Biosensor reveals new information about suspected cause of Alzheimer's disease
...he size and structure of a miniscule toxic protein suspected of triggering Alzheimers disease. The findings, researchers say, could help scientists better understand the underlying mechanisms of the disease and lead to the development of new treatments that could slow or possibly arrest its progression. The fi...Report reveals high rate of heart attack amongst ethnic minorities in Scotland
...llustrates what many in the health profession have suspected for years - that some ethnic minority communities suffer disproportionately from health problems, particularly around heart disease. "Building up a comprehensive picture of the relationship between ethnicity and health is crucial if we are to most e...Standardized guidelines improve outcomes in stroke care
...t. Its data includes all patients diagnosed with a suspected stroke or TIA (mini stroke), at admission or discharge, who were admitted to one of seven medical institutions in California, including UCSF Medical Center....BMJ highlights lack of international cooperation to investigate scientific fraud
...e argue that journals should keep "black lists" of suspected papers and authors. Others suggest that journals should ask authors to deposit a copy of their raw data in a secure archive so that these could be audited if questions arise. Perhaps journals should be more ready to share their concerns about publish...Minimally invasive solid tumor biopsy may replace surgery to get diagnostic specimens
...e to surgery for obtaining diagnostic samples of a suspected solid tumor in children, according to results of a...ars. Adults were included in this study because of suspected recurrence or metastasis (spread) from previously diagnosed childhood cancers. The researchers deter...Predicting the outcome of drug-induced liver disease
...gust 2005 issue of Hepatology, analyzed reports of suspected drug-induced liver injury received by the Swedish ...had mixed liver injury. In 633 cases, one drug was suspected of causing the liver injury, while in 151 cases more than one drug may have been responsible. A tota...Small-bowel injury in children more common in abuse than accident cases
...aediatricians should look more closely at children suspected of being abused to exclude intra-abdominal injury. We have shown that small bowel injury can occur accidentally from road traffic accidents or falls but it is more common in abused children. Injuries to the small bowel need special consideration espe......ease alone. After controlling for other known or suspected risk factors, the researchers found that patients who had ever used statins had no reduction in their risk of developing dementia from any cause (Alzheimer's disease, mixed Alzheimer's disease and vascular dementia or vascular dementia alone) compare...