Draining away brain's toxic protein to stop Alzheimer's
...o try to reduce amyloid-beta levels in the body by synthesizing an altered, super-potent form of sLRP that binds amyloid-beta more efficiently than natural sLRP. In blood samples from patients with Alzheimers disease, the modified version of sLRP, known as LRP-IV, soaked up and virtually eliminated amyloid-beta. ......e, and biocompatible. The researchers start out by synthesizing gold nanoparticles within amine-terminated dendrimers. Next, dye molecules and a targeting molecule, folic acid, are attached to the ends of the dendrimers. Finally, the remaining amine groups are acetylated to ensure that the complex particles do no...How to lose weight and not go hungry: HU researcher develops drug that mimics feeling of 'fullness'
...niversity researchers developed a novel method for synthesizing a peptide (a peptide is a compound linking two or more amino acids) which can serve as an analog to the naturally occurring aMSH hormone. They were able to demonstrate that their peptide, which they call BL-3020, displayed good metabolic stability to...Scientists equip bacteria with custom chemo-navigational system
...reprogramming bacteria so that microbes capable of synthesizing an anti-cancer drug, for instance, can be used to target diseased cells while sparing healthy cells of side effects. Likewise, scientists are researching ways to use bacteria to clean up oil spills or remove other pollutants from soil, water and wast...Tissue engineered scaffolding allows reproduction of cartilage tissue
...lage cells to maintain their characteristics while synthesizing cartilage in the scaffold structure in vivo," notes study author Dr. Byoung-Hyun Min. "Cell-derived scaffolding may hold great promise for the future. A variety of applications are possible for the engineering of cartilage tissue as the shape and por...Northwestern chemists develop new method for synthesizing anti-cancer flavonoids
...ght hand are very similar but are not the same. In synthesizing flavonoids, you want to make one handedness over t...nd pharmacist," said Scheidt, who looks forward to synthesizing and evaluating new compounds with Bergan. "We may not be quite as sophisticated as nature, but our c...National Inventors Hall of Fame announces 2007 inductees
...2000) and Miguel Ondetti (1930-2004) Captopril By synthesizing captopril during their careers at Bristol Myers Squibb, Cushman and Ondetti created the first medical treatment that significantly reduced hypertension. Captopril ws the first of a new class of drugs called ACE inhibitors. Donald Davies (1924-200...Novel Ames Lab composite may replace depleted uranium
...ientist Dan Sordelet leads a research team that is synthesizing nanolayers of tungsten and metallic glass to build a projectile. "As the projectile goes further into protective armor, pieces of the projectile are sheared away, helping to form a sharpened chisel point at the head of the penetrator," said Sordelet....BC catalyst discovery promises faster, cheaper drug production
...eral costly and wasteful steps from the process of synthesizing certain molecules. "Our new catalyst will significantly improve the efficiency with which biologically and medicinally active molecules can be prepared," said Prof. Hoveyda, who is also chair of the department. "Such a catalyst, by shortening synthe...Journal of Evidence-Based Dental Practice joins the curriculum at NYU College of Dentistry
...elop critical skills in filtering, appraising, and synthesizing information for use in clinical decisions, in order to achieve optimal health outcomes for every patient in any number of clinical circumstances." Billed as "The Clinical Connection to Evidence and Innovation," The Journal of Evidence-Based Dental ...New compound unusually potent at blocking brain cancer growth
...s. In the Cell paper they described their success synthesizing a panel of different PI3 kinase inhibitors, showing for the first time the structural basis of the inhibitors' abilities to block different PI3 kinases. They used the new compounds to dissect the role of PI3 kinases in insulin signaling and in cancer...Growing health effects of global warming outlined on regional scale
...ealth at the Australian National University. "This synthesizing paper points the way to strategic research that better assesses the risks to health from global climate change." The UW-Madison and WHO assessment appears only weeks before global leaders convene in Montreal during the first meeting of the Conferenc...Work on cancer-killing compound nets FSU professor major grant
...ific breakthrough in his lab enabled a process for synthesizing large quantities of taxol, a compound derived from the Pacific yew tree that has proven successful at combating breast cancer. "I came to FSU as an undergraduate and met Professor Holton then," Dudley said. "His presence was one of the factors that d...Hebrew University researcher develops compounds to control bacteria
... quorum sensing process. Jabbour has succeeded in synthesizing modified chemical compounds, resembling the structure of the natural auto inducer-2, that can disrupt the signaling. By altering the molecular structure in these compounds, Jabbour was able to show that it is possible to control the quorum sensing re...New fat is needed to clear old fat from the system
...netically engineered mice missing an important fat synthesizing enzyme in the liver. As a result, the mice, called FASKOL mice (Fatty Acid Synthase KnockOut in Liver), could not produce new fatty acids in the liver. Because liver fatty acids are vital for maintaining normal sugar, fat and cholesterol metabolism, ......s like some cholesterol-lowering drugs. Until now, synthesizing this framework - an indole - was inefficient, requiring six to 10 steps and often producing toxic by-products. "This new method only takes three steps and results in less waste," says Lautens, the NSERC-Merck Frosst Industrial Research Chair in New M...