DNA vaccine against multiple sclerosis appears safe, potentially beneficial
...elated diseases, such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and myasthenia gravis, the authors conclude....Warfarin better than aspirin at stroke prevention in elderly people with atrial fibrillation
...21 strokes, two intracranial haemorrhages, and one systemic embolus. In the aspirin group, there were 48 serio...4 strokes, one intracranial haemorrhage, and three systemic emboli. Thus patients taking warfarin were less than half as likely to suffer a serious event (52% l...Stem cell transplantation procedure results in long-term survival for amyloidosis patients
...-term survival for patients diagnosed with primary systemic light chain (AL) Amyloidosis. The findings appear prepublished in the First Edition of Blood and can be viewed on Blood Online at http://www.bloodjournal.org/papbyrecent.shtml . BUMC was the first to begin using this treatment in 1994 and is the...Low libido in menopause linked to trouble sleeping
...ith interest in sex. Likewise, she added, although systemic hormone therapy with estrogen can reduce vaginal dryness, it can also lower womens natural testosterone, which affects some womens libido. Before starting any drug treatment for changes that happen in menopause, women need to weigh their individual...GSK announces launch of largest ever Phase III trial in lung cancer treatment
...vents were mild local (pain, redness, swelling) or systemic (fever, fatigue, muscle pain) reactions observed within the 24 hours of injection. Out of 182 patients, one patient was withdrawn from the clinical trial due to adverse events possibly related to the MAGE-A3 treatment. Based on available results, GSK...Cedars-Sinai researchers present new endocrine findings at 2 international conferences
...inking the pituitary gland to the understanding of systemic illness, mental disorders and the aging process, advances in subcellular mechanisms in the pathogenesis of pituitary disorders, and the publication of new data reflecting long term medical treatment outcomes in patients with acromegaly. Melmed, who ...Vorinostat shows anti-cancer activity in recurrent gliomas
...l lymphoma in patients who have failed two or more systemic therapies. An additional group of patients in this study was treated with vorinostat prior to surgery, and a gene and protein analysis of their resected tumors was performed. This analysis confirmed increase in histone acetylation and showed gene cha...Pre-operative chemotherapy does not increase survival rates for nonsmall cell lung cancer
...n-small cell lung cancer, not be delayed, and that systemic treatments should be administered postoperatively....GSK's Pazopanib shows positive results in patients with advanced renal cell carcinoma
...nced or metastatic RCC who have not received prior systemic therapy or have failed one prior therapy (cytokine or bevacizumab-containing regimen). All patients received 800 mg of pazopanib taken orally, once-daily during a 12 week lead-in period. Based on data available on 60 patients at the time of a plann...GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer
...nced or metastatic RCC who have not received prior systemic therapy or have failed one prior therapy (cytokine or bevacizumab-containing regimen). All patients received 800 mg of pazopanib taken orally, once-daily during a 12 week lead-in period. Based on data available on 60 patients at the time of a plann...Human stem cell treatment restores motor function in paralyzed rats
...t for debilitating muscle spasticity is continuous systemic or spinal drug treatments using implanted pumps. These approaches, while effective to a degree, are often accompanied by side effects and eventual drug tolerance that lessens their efficacy. These research findings could offer great hope to people...Research shows aerobic exercise helps maintain muscle in elderly
...tion in which either a complete lack of insulin or systemic resistance to the hormone's activity (as in type 2 diabetes) causes blood sugar levels to soar out of control. Recent studies have shown, however, that insulin also provides crucial assistance in building muscle, and that its ability to do so drops o...Help for pediatricians in treating behavioral health problems only partially successful
...th disorders in primary care is evolving. She said systemic changes including use of financial incentives to motivate primary care pediatricians to identify, treat and refer behavioral patients, increased access to mental health providers for consultations, practice guidelines and use of technology for contin...High pretreatment PSA velocity predicts worse outcome
...h aggressive prostate cancer and in whom effective systemic treatment in addition to mono-therapy with RP or RT is needed to decrease PCSM rates."...New insights into chronic inflammation and atherosclerosis
... remain unclear. Does atherosclerosis result from systemic inflammation, a hallmark of these rheumatic diseases, or from local inflammation of vessels? To shed light on the link between chronic inflammation and atherosclerosis, a team of researchers in Norway and the United States, affiliated with the Clev...Nearly half of children in Kenya with common type of severe malaria affected neurologically
...ugh prostration may be a general feature of severe systemic illness, the occurrence of seizures in 60 percent of patients suggests frequent involvement of the central nervous system."...Novel treatments may help alleviate constipation, IBS in women
...fect locally in the intestine while having minimal systemic exposure. Thirty-six women suffering from IBS with constipation (IBS-C) were examined in a double-blind, placebo-controlled study, which consisted of a five-day baseline and a five-day treatment period. The endpoints were gastrointestinal transit...Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
...ations is one of the most promising strategies for systemic siRNA delivery, and such nanoparticles are expected to enter Phase I clinical trials by late 2007. Our most recent work examines the impact of various dosing schedules and surface modifications on the efficacy of these siRNA nanoparticles in preclini...Smoking and sleep top the list of lifestyle factors impacting oral health
... as the body of evidence linking oral disease with systemic diseases continues to grow because ultimately these lifestyle factors might impact a patient's overall health."...Treatment of kidney condition requires an individualized approach
...dney inflammation caused by the autoimmune disease systemic lupus erythematodes. The body produces antibodies against its own organs and treatment is absolutely necessary. The condition is rare. Each year 6 in every 100,000 people in the Netherlands develop the disease. Up until 40 years ago patients died fro...