Blocking the Odc gene is effective in preventing cancers
...ssing drug DFMO induces p27Kip1 and p21Cip1, which then act as brakes on cell division in laboratory models that normally give rise to BL. The St. Jude investigators also showed that tumors from eight of 14 patients with BL also over-expressed the Odc gene, which indicates that this gene is an important t...UCLA researchers find common gastrointestinal condition keeps patients up at night
... acid backs up as far as the throat and voice box, then the sleeper may wake up coughing and choking. If the acid only backs up as far as the esophagus, then the most common symptom is heartburn. 5 The symptoms most likely to wake them include persistent co...60 per cent of first-time mums say prolonged labour will affect them for life
... with assisted vaginal or caesarean delivery. They then compared their experiences with 171 women who had had normal deliveries. Just over a third of women who had experienced prolonged labour (34 per cent) felt negative about the overall experience, compared with just four per cent of women with a normal...Study demonstrates longest reported survival rate for locally advanced lung cancer patients
...on-small cell lung cancer. But S0023 patients were then randomized to receive either a placebo or gefitinib (Iressa) as maintenance therapy. The study was designed to assess whether maintenance therapy with gefitinib improves overall survival and progression-free survival. The interim analysis of 573 pat...Antibody combined with cancer drug shows promise against breast tumors
...ut and be positioned on the external surface. VTAs then can bind to this exposed phospholipid, causing the body's white cells to attack and destroy the vessels feeding the tumor. By targeting receptors unique to tumor vessels, vascular targeting agents kill tumors without causing damage to surrounding hea...Researchers prevent post-traumatic brain damage
.... Combined with inflammation, this wave of damage then continues to progressively kill vital brain cells,...you can shut down this delayed response to injury, then the lesion won't spread, the scar won't form, and you could save a lot of tissue that would have die...New methods offer alternatives for patients undergoing obesity surgery
...ure ranged from 60 to 90 minutes and patients were then followed for three, six and nine months, with no significant complications reported. Patients were able to return to work the following day. This pilot study demonstrates that the less-invasive method used in endoscopic intraluminal suturing is safe...New class of drugs may treat lung tumors resistant to Iressa and Tarceva
...resistance mechanisms must exist. The researchers then started with Iressa-sensitive NSCLC cells and crea...face, move inside the cell, release the ligand and then move back to the cell membrane,"says Haber, a professor of Medicine at Harvard Medical School. "We'...Changing medication packages could help patients follow prescriptions, study suggests
...vidual pills are put in small plastic bubbles, and then backed with foil. A person pushes on the bubble, forcing the pill through the foil to retrieve it. The card also has more room to print important information about the proper use of the medication. Although putting medication in blister packs isn't a...Biologic therapies for bowel disease show promise in clinical trials
...nd 10 mg/kg or placebo at weeks zero, two and six, then every eight weeks for 46 weeks (ACT I) or 22 weeks (ACT II). Patients in both studies were assessed for clinical response (defined as a decrease in Mayo score of =30 and =3 points, accompanied by a rectal bleeding score of 0 or 1 at week eight), cli...New therapy may give options to those with neuroendocrine tumors
...took the drug as a pill once a day for four weeks, then went without the drug for two weeks to complete the cycle. Patients continued cycles for a year. The study presented data on 93 patients-52 with islet cell tumors and 41 with carcinoid tumors. Among islet-cell patients, five had a partial response to...New stomach cancer therapy potentially more convenient and better tolerated
...fusion of cisplatin on the first day of treatment, then took S-1 twice a day every day for three weeks, and took a week off to recover before starting the cycle all over again. In all, 41 patients participated and were evaluable; researchers have examined information on the drug's safety in 30 patients a...Nutrition gene key in regulating immune system
... through food. "If the T cells are just starving, then you don't need a receiver. They just die. But the T cells didn't seem to be dying. They seemed to be rendered selectively non-responsive," says Dr. Munn. "That sounded more like the T cell was participating in this process." So the researchers starte...Richard A. Meyer, MD, receives the 2005 AIUM William J. Fry Memorial Lecture Award
...ospital in Cincinnati, Ohio, from 1965 to 1967. He then took a 2-year break from Children's Hospital to se... in the planning and designing of the AIUM office, then in Rockville, Maryland. Much of his planning and design efforts were carried over to the current AIU...Researchers find way to streamline new non-Hodgkin's lymphoma treatment
... imaging scan within 24 hours of the injection and then again within two to three days to verify that the radioactivity is going to the cancer sites. Some even perform more scans four to five days later. But Conti and colleagues found that most of those scans are unnecessary. In their study, they saw that...Cutting-edge technologies signify a new era for colorectal cancer screening
...imensional map of the patient's colon. The System then directs each of the segments to follow the shape of the colon, as identified by the physician. Because the System is designed to follow the natural shape of the colon, less force is applied to the colon wall. This could potentially eliminate or sig...Timing of introduction of gluten into infant's diet associated with appearance of celiac disease
...sposed individual at risk for celiac disease. Only then will it be possible to know the true effect of exclusive vs. partial breastfeeding, gluten amount vs. gluten timing, and infant cereal vs. follow-up infant formula on celiac disease risk and presentation," Dr. Farrell writes. (JAMA. 2005;293:2410-2...Ultrasound images transmitted over phone allow real-time diagnosis of patients in poorer countries
...eed the file transfer. The compressed images were then compared to the original noncompressed images," said Dr. Popov. Two attending radiologists, one radiology resident and a medical student reviewed both sets of images, and in 64% of the cases, they couldn't tell the compressed from the noncompressed ...Genes may influence nutritional composition of breast milk
...111 women ate a meal with an added dose of DHA and then pumped their breast milk hourly for 12 hours. The researchers then analyzed the amount of DHA and other fats in their blood and breast milk, and determined which women...Newly discovered 'branding' process helps immune system cells pick their fights
...tides, changing it to nitrotyrosine. Unanue's lab then showed that these changes increased the chances that various types of T cells would react to the modified peptides shown to them by antigen-presenting cells. Unanue's group is working to substantiate their findings and explore their potential releva...