Using coxibs and NSAIDs to treat osteoarthritis
...described a stepped care approach to pharmacologic therapy for musculoskeletal diseases. The Editorial strong...dose aspirin be administered alone as a first line therapy for patients with chronic pain and arthritis. Dr Roland W. Moskowitz, Professor of Medicine at Ca...New treatment boosts muscle function in myasthenia gravis
... gravis. Oral antisense may become another mode of therapy in neuromuscular disease and further study is needed, said Argov. However, these preliminary results should be evaluated with caution since this was an open label study. Argov says further research is underway to look at the effects of this drug ...Grandparents, older adults encouraged to seek help for a sleep disorder
...cieties, this past June: Cognitive behavioral therapy successfully improves both immediate and long-term self-reported sleep and pain in older osteoarthritis patients. This demonstrates that improving sleep can be analgesic in older osteoarthritis patients, and that techniques to improve sleep should b...New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
...ll lines changed from being sensitive to endocrine therapy to being resistant, we saw an increase in spliced XBP1 inside the cell. So then we took sensitive cells and added spliced XBP1, which made them resistant to the therapy, explained Clarke, who is interim director of Georgetowns Biomedical Graduate Res...Nationwide data highlight encouraging trends, 'staggering' costs of ESRD
...dence that patients are starting renal replacement therapy at a less-severe stage of kidney disease. The increased use of fistulas for dialysis access reduces problems associated with the use of grafts or catheters. At the same time, there is continued concern about overaggressive use of drugs called erythro...Stanford researchers find culprit in aging muscles that heal poorly
...ng how inhibiting Wnt signaling might help provide therapy for that disease. Wnt has also popped up unexpectedly in work by researchers at the National Institutes of Health, published in the same issue of Science, who were studying the effects of a deficiency of a hormone called klotho. Klotho deficiency c...Warfarin better than aspirin at stroke prevention in elderly people with atrial fibrillation
...ulants [warfarin] were more hazardous than aspirin therapy in this age group, although the study had limited power to detect those differences. In an accompanying Comment, Dr David Garcia, University of New Mexico, Albuquerque, USA, says: BAFTA firmly establishes the superior efficacy of warfarin as a stro...Where's the beef? Not enough of it is on elders' plates, muscle-metabolism study suggests
...sociate professor in UTMBs departments of physical therapy and internal medicine. Paddon-Jones is the senior author of a paper on the study published in the August issue of the American Journal of Clinical Nutrition and now available online. The investigation compared changes in muscle protein synthesis in...Penn researchers discover novel pathway for increasing 'good' cholesterol
...ther the PC or EL enzyme might be targets for drug therapy to raise good cholesterol, an unmet medical need in patients with low HDL-C, says Rader. Whats more, the increase in HDL-C was shown to promote reverse cholesterol transport, the process by which HDL protects against heart disease. Low levels of HD...New research discovers independent brain networks control human walking
...s and adapts in relation to motor skills, physical therapy professionals have a vastly expanding toolbox from which to tailor therapeutic interventions, explains Gary Goldstein, MD, President and CEO of the Kennedy Krieger Institute. This study and other research from Kennedy Kriegers Motion Analysis Laborat...Chemotherapy with bevacizumab increases risk of blood clots in arteries
... The clinical benefit associated with bevacizumab therapy was maintained for all subgroups. Although death from [a blood clot in the artery] was uncommon, we did not capture functional disabilities from these events, and the risk factorsidentified in this study should be considered when making treatment dec...Osteoporosis screening and treatment may be cost-effective for selected older men
...phonate (a class of drugs used to strengthen bone) therapy for men found to have osteoporosis. The researcher... bone densitometry followed by oral bisphosphonate therapy among those found to have osteoporosis for all men aged 70 years or older regardless of fracture his...Backache sufferers who fear pain change movements
...r, said Thomas, an associate professor of physical therapy whose study is funded by a four-year, $1.5 million grant from the National Institutes of Health. "It's like if you run every day, and then a friend invites you to a game of racquetball," Thomas said, noting that the sports use different muscle gro...ACC/AHA release revised UA/NSTEMI guidelines
...e angiogram; recommending the use of anti-platelet therapy clopidogrel for at least one year after receiving ...e control. More stringent LDL cholesterol-lowering therapy and blood pressure management is recommended for UA/NSTEMI patients. LDL (bad cholesterol) should be...Inhaled nitric oxide safe for tiny preemie lungs, UCSF study finds
...produce insufficient amounts of surfactant, so any therapy that inhibited the work of surfactant would be harmful. In the study, half the infants were treated with nitric oxide and half received a placebo. Fluid from their lungs was then collected and examined for surfactant levels and properties. Finding...Why women get more migraines than men
...ms of migraine are leading to novel approaches for therapy for the hundreds of millions of individuals worldwide who suffer from this disabling condition....Statin drugs may delay progressive artery damage in children
Starting statin therapy as young as age 8 safely and effectively delays th...ation. Our data support early initiation of statin therapy in FH children, which might yield a larger benefit in the prevention of atherosclerosis later in lif...Many heart attack patients still not getting emergency clot-busting treatment
... who had had a type of heart attack for which this therapy is appropriate between 1994 and 2003. Its the m...subgroups still less likely to receive reperfusion therapy despite eligibility, so that we can focus our clinical efforts on them. Adds senior author Harlan ...Electric fields have potential as a cancer treatment
...nts were still alive two years after the electrode therapy started. These results were announced in a recent ...ng the possibility of combining the electric-field therapy with low-dose chemotherapy. ......ew of her condition which she controls with daily therapy and medication. I wanted to write this book to give hope to people who suffer from schizophrenia and understanding to people who dont, said Saks, an expert in the field of mental health law who also holds faculty appointments at the Keck School ...