Study shows Diachrome improves blood sugar control in people with type 2 diabetes
...tes on oral anti-diabetic medications. Safety and tolerability were also assessed. Results showed a significant reduction in A1C levels for the treatment group (-0.54%) compared with the placebo group (-0.34%). The highest risk patients (baseline A1C equal to or greater than 10%) showed an even greater improve...Drug shows activity against brain metastases
... 11:15 a.m. (N Hall, B1). The trial examined the tolerability and efficacy of lapatinib in a Phase II study that included 241 patients who had been treated with the drug Herceptin for stage IV HER2-positive breast cancer, and had developed metastases to the brain. About 30 to 40 percent of women treated with He...Targeted, oral agent Enzastaurin shows favorable results
...dizziness. Based on the encouraging survival and tolerability data gathered thus far, further evaluation of en-zastaurin in NSCLC, as a single agent or in combination, is warranted, said chief investigator for the study, Gerold Bepler, M.D., Ph.D., chief of thoracic oncology at the H. Lee Moffitt Cancer Center ...New research supports early testing for prostate cancer
...hese patients to compare both efficacy and patient tolerability between these two forms of hormonal treatment. No statistically significant difference was seen in androgen-independent disease progression between the two groups. However, patients treated with IAD had an improved quality of life and fewer hot fla...New class of HIV drug attacks previously untargeted enzyme
...l therapy. They add: "The promising efficacy and tolerability profile of raltegravir suggest that this drug has the potential to become an important component of combination treatment regimens used to treat heavily pretreated patients failing current therapies with multidrug-resistant virus and limited treatmen...Bayer and Onyx announce pivotal Nexavar kidney cancer study published in NEJM
.... "This landmark study demonstrated the efficacy, tolerability and clinical benefit of Nexavar, which has rapidly become a valuable weapon against this devastating disease." Based on these data, Nexavar was granted U.S. Food and Drug Administration (FDA) approval for the treatment of patients with advanced R...Penn researchers demonstrate ability of new therapy to treat severely elevated cholesterol levels
...ted a dose-escalation study to examine the safety, tolerability and effects on lipid levels of an inhibitor of MTP in six patients with homozygous FH. Patients received the MTP inhibitor at four different doses, each for four weeks, and returned for a final visit after an additional four-week drug washout period....Study in the Journal of Clinical Pharmacology
...renal function on the pharmacokinetics, safety and tolerability of palifermin after a single IV injection.The clinical trial consisted of 31 participants with varying degrees of renal function, from normal to end-stage renal disease requiring hemodialysis. Each participant received a single dose of the drug, p...Individualized strategies needed for prevention of malaria in long-term travelers
...n personal protective measures, and the safety and tolerability of malaria treatments during long-term use and to consider prevention strategies. The studies indicated that long-term travelers (more than 6 months) have a higher risk of malaria than short-term travelers. "Long-term travelers underuse personal pro...The Journal of Clinical Pharmacology looks at effects of smoking cessation drug, varenicline
...t on the first clinical trial studying the safety, tolerability and pharmacokinetics of the drug varenicline on 65...from the study. "It is important to evaluate the tolerability of a potential treatment for smoking cessation," write the authors. "The normal physiologic processe...New data reinforce safety profile of ENBREL (etanercept)
...ve become familiar with the benefits and long-term tolerability profile of ENBREL since it was approved six years ago. Worldwide, 441,000 patients have been treated with ENBREL. It acts by binding tumor necrosis factor (TNF),3 one of the dominant inflammatory cytokines or regulatory proteins that plays an import...Tibotec Therapeutics announces start of largest US study on HIV treatment in women
...are gender differences in the efficacy, safety and tolerability of PREZISTA (darunavir) tablets administered with ... research suggesting that women may have different tolerability issues to HIV medications than men. "GRACE is a landmark study because HIV treatment trials inclu...OREXIGEN reports positive 24-week results for Contrave phase III obesity treatment study
... this middle dose provides the best combination of tolerability and efficacy. Patients completing the 24-week trial and receiving Contrave with the lowest dose of naltrexone also experienced weight loss with improved tolerability. No serious adverse events attributed to Contrave were reported by the study's in...Study shows men with ED favor treatment with Vardenafil
...of which have previously demonstrated efficacy and tolerability in a range of patient populations, according to researchers. Data from head-to-head clinical trials, like this one, are scarce. However, results from studies such as this should help clinicians to differentiate among sildenafil, vardenafil, and tad...Pine tree bark reduces diabetic leg ulcers
... weeks. Direct questioning was used to evaluate tolerability and compliance, particularly gastrointestinal problems, systematic and local skin alterations, signs of allergic reaction and any other manifestation. No side effects were reported. Over 35 years of research on Pycnogenol demonstrate the antioxida...Study drug holds promise as alternative to castration for early prostate cancers
...s Dr. See "Here we have evaluated the efficacy and tolerability of a non-castration-based therapy, and found the survival rates to be similar."...New medication appears effective in helping smokers kick the habit
...placebo-controlled study to evaluate the efficacy, tolerability and safety of varenicline for smoking cessation. ... than those for placebo while demonstrating a good tolerability profile in this population of smokers who on average had smoked approximately 20 cigarettes per day ...New data demonstrate effectiveness of LAMICTAL (lamotrigine) as adjunctive therapy
...led study was conducted to assess the efficacy and tolerability of adjunctive therapy with LAMICTAL in the treatme...0 years of age and was associated with a favorable tolerability profile. ABOUT EPILEPSY Epilepsy, defined by recurrent unprovoked seizures, is a change in sen...Cerebrospinal fluid used to deliver therapeutics for Lou Gehrig's disease to brain
...g second-generation oligonucleotides with enhanced tolerability and potency, the authors were able to modulate and deliver effective doses of antisense oligonucleotides. Antisense oligonucleotides to the enzyme superoxide dismutase reduced protein and mRNA levels in the CNS. Delivery of antisense therapy initiate...GroPep awarded key patent for infertility treatment in Europe
...clinical trial on PV903 to evaluate the safety and tolerability of vaginally administered PV903 gel and to determine whether PV903 has effects on vaginal immune cells in a manner consistent with its proposed role in treating immune-based infertility. Results from the trial are expected during the second half of...