Institute of Medicine news: Review of HIVNET 012 study
...ne the impact of other recent studies of potential toxicity or resistance buildup associated with the use of nevirapine either in short- or long-term treatment of HIV-infected individuals. Because of inconsistencies in and challenges to previous audits, the committee undertook its own assessment of the accura...Combination chemotherapy shows small survival benefit in advanced stomach cancer
...oes indeed compensate for the burden of additional toxicity to be endured by the patient," Wagner says. The overall rate of toxic deaths among the studies was 2.1 percent for combination chemotherapy and 0.9 percent for single-drug therapy, according to the Cochrane researchers. Although nine of 10 relevant s...Age is not a limiting factor in combined therapy for lung cancer
...ce is not statistically significant. While overall toxicity was similar between the two age groups, specific moderate and severe toxicities occurred more frequently in the elderly. Severe pneumonitis requiring ventilation or continuous oxygen was significantly more common in the elderly, occurring in 6 percen...Giving children access to drug clinical trials is crucial, clofarabine approval shows
...developed to improve the efficacy and minimize the toxicity of two similar drugs, cladribine and fludarabine. The other author of this paper is Peter Kirkpatrick (Nature Reviews/Drug Discovery)....Study is first to implicate dietary fat in 'fatty liver'
...sited in the liver. This leads to a kind of liver toxicity that would be good to avoid," said Parks....Children with high blood lead levels often do not receive follow-up tests
...line in children's blood lead concentrations, lead toxicity remains a major public health problem. Environmental lead exposure in children has been associated with an increased risk for reading problems, school failure, delinquency, and criminal behavior," Dr. Lanphear writes. "The effects of lead exposure e...Mayo Clinic researchers use pharmacogenetic test prior to chemotherapy to reduce toxic side effects
...rior to the start of chemotherapy can decrease the toxicity of a three-drug chemotherapy regimen, thus helping... difficulty putting the drugs together because the toxicity can be lethal. The genetic test detects a change in the DNA of a gene that encodes for a protein inv...Vitamin D, taxotere combination promising for advanced prostate cancer
...ves of men with advanced prostate cancer. And, the toxicity of the combination therapy proved to be no greater...known about the anti-tumor potential of vitamin D, toxicity has been a significant issue to be overcome in making it a successful part of prostate cancer therap...Researchers prevent post-traumatic brain damage
... but has not been proven successful because of the toxicity associated with sustained use, said Di Giovanni. But the researchers thought that it might work, and with limited side effects, if the drug was used just once. So, in this study, they delivered flavopiridol to the animals 30 minutes after brain inju...Jefferson researcher's results show promise for metastatic eye melanoma
...he trial, which was aimed at testing for treatment toxicity and feasibility, Dr. Sato found that 30 percent of 39 patients studied (34 of whom had uveal melanoma) had tumor shrinkage and another 30 percent had tumors that didn't grow. He presents his team's findings May 17, 2005 at the annual meeting of the ...Mayo researchers to announce new findings about promising early-stage breast cancer treatment
...e time they entered the study, the risk of cardiac toxicity was 2.2 to 3.3 percent for patients who received a... heart muscle damage. "The incidence of cardiac toxicity at this follow-up time is within what was expected at the time of trial design. But patient follow-u...Breast cancer chemotherapy regimen associated with life-threatening complications
...rminated prematurely when 2 deaths related to drug toxicity and 1 case of bowel perforation with peritonitis (...tions. Clinicians should be aware of the potential toxicity of the doxorubicin-docetaxel regimen and consider the preventive use of granulocyte colony-stimulati...Steroid-free regimen with CellCept found comparable to standard therapy in liver transplantation
...ctive, open-label randomized trial to evaluate low toxicity regimens including CellCept. The study will take place in more than 35 transplant centers in the U.S. and Canada. The study, which will recruit 340 liver transplant recipients, is designed to evaluate the efficacy and safety of a regimen of CellCep...Study finds drug works against scleroderma lung disease
...roup was the same-2 patients each. "Nobody died of toxicity from the drug," Dr. Tashkin said. "We know cyclophosphamide has toxic effects, but you have to balance the efficacy of the drug against its toxicity. It's a desperate disease, and nothing else has proven effective. We feel the benefits outweigh the r...Tiny bundles seek and destroy breast cancer cells
... to travel through the bloodstream without causing toxicity and release the ceramide in the tumor." Although the mechanism remains unknown, ceramide is inherently attracted to tumor cells. The liposome-encased ceramide travels through the bloodstream to the tumor where it enters the tumor cells through the tu...Personalized immunosuppression with leading organ transplant therapy may optimize patient care
... evaluate TDM strategies. The goal is to minimize toxicity and maximize efficacy of CellCept-containing regimens," said Robert Gordon, M.D., senior medical director at Roche and a former transplant surgeon. "We hope to provide the transplant community with robust information on monitoring CellCept levels so...Shorter course of radiotherapy effective for palliation of painful bone metastases
...e was a higher rate of re-treatment but less acute toxicity in the group that received only one course of 8 Gy radiation compared with the 30-Gy group. "Further analysis of data from [this] trial should yield important information on quality of life, health utilities (i.e., patient preferences for specific h...Chemotherapy options improve for patients with advanced colorectal cancer
... conclude that CAPOX shows comparable efficacy and toxicity profiles compared to the FUFOX regimen in patients chemonaive MCRC. "This study is important for patients because the CAPOX regimen is more convenient to administer. Patients will appreciate needing to come only twice in three weeks as outpatients to...National medical and public health groups sue EPA
...gnored the annual economic costs of methyl mercury toxicity attributable to mercury from American power plants...health and economic consequences of methyl mercury toxicity to the developing brain. Trasande, Landrigan and Schecter). The loss of intelligence continues ......anoparticle system, we may be able to overcome the toxicity problem and provide a broader range of therapeutic agents for people with cancer." By attaching different targeting molecules and different drugs to the nanoparticle, Baker believes scientists eventually will be able to develop effective therapies fo...