Tag: "toxicity" at medical news

Study suggests use of stem cell transplantation is beneficial treatment of type 1 diabetes

...iods of insulin independence and treatment-related toxicity was low, with no mortality. Further follow-up is necessary to confirm the duration of insulin independence and the mechanisms of action of the procedure. In addition, randomized controlled trials and further biological studies are necessary to confir...

UCSF brain tumor vaccine trial shows promising results

.... According to investigators, no adverse events or toxicity identified were considered attributable to the vaccine. Cheryl Canagelo, a 52-year-old woman from Oakley, Calif., came to UCSF for a second opinion after undergoing radiation and chemotherapy elsewhere for treatment of a glioma. At UCSF she learn...

New prostate cancer treatment wins operations research award for Sloan-Kettering

...ontrol outcomes were excellent at 5 years and late toxicity was unusual. These data demonstrate that real-time planning methods can consistently and reliably deliver the intended dose distribution to achieve an optimal therapeutic ratio between the target and normal tissue structures." Resulting reduction...

Dealing deadly cancers a knockout punch

...n prefer to treat cancer with multiple agents, but toxicity limits these approaches. Since reovirus typically ...ot pathogenic in humans nor associated with severe toxicity in clinical studies, its co-administration is not expected to increase a treatment's overall toxicit...

Commercializing university research -- Hopping robots, liquid shoes, electricity from heat

...cient modules for pharmaceutical screening of drug toxicity and drug metabolism."The basic technology utilizes...fficient pharmaceutical in vitro screening of drug toxicity and drug metabolism. Further monochip development into modular arrays, composed of hundreds to housa...

Panel offers guidelines on skin reactions to new class of cancer drugs

...als and patients see EGFRI-associated dermatologic toxicity as manageable, thereby optimizing clinical benefit from continued and uninterrupted use of EGFRIs when possible," according to lead author Dr. Thomas J. Lynch, Jr., of Massachusetts General Hospital, Boston. Treatment with EGFRIs has been shown to...

Increasing radiation dose shortens treatment time for women who choose breast sparing treatment

...primary endpoint was acute skin toxicity. "Acute toxicity on this clinical trial is not only acceptable but ...treatment, none of the women had grade 3 or 4 skin toxicity or dermatitis (skin inflammation). Twelve percent had grade 0, 65 percent had grade 1, and 23 perce...

New system for reporting toxicity burden of cancer treatment

A new system for reporting the relative toxicity burden of different cancer treatments is proposed ...t data into three concise risk domains: short term toxicity (T), adverse long term effects (A) and mortality risk (M), which are calculated for each treatment p...

Lilly studies try to shed light on impact of race

... the treatment of NSCLC, viewing data outcomes and toxicity data of 128 African-Americans compared with 906 Caucasians. The trial was designed to compare the efficacy of GEMZAR plus carboplatin with GEMZAR plus paclitaxel and a reference regimen of carboplatin plus paclitaxel. Data from all three arms were po...

Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer

...a first-line ALIMTA-based regimen may deliver less toxicity than a commonly used therapy in advanced non-small.... Thus far, 384 patients have been analyzed for toxicity and there were fewer patients in the ALIMTA arm who experienced Grade 3/4 thrombocytopenia or a low ...

Targeted, oral agent Enzastaurin shows favorable results

... daily, until disease progression or un-acceptable toxicity occurred. In the 54 patients enrolled, the median ...s was 46.3% (95% CI: 32.1%-60.5%). The most common toxicity was fatigue. Additional toxicities observed included ataxia (n=1), thromboembolism (n=1), anemia (n=...

Radium-223: An alternative treatment for prostate cancer

...um-223 patients stopped treatment due to treatment toxicity However, radium-223 treatment had no significant effect on the timing of skeletal related events (SREs) another key indicator of HRPC progression. These include, among other factors, a 25% increase in pain severity, increased painkiller consumptio...

GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer

...le complete remissions observed in 7% of patients, toxicity has limited its widespread use. Lower dose cytokine therapies have not shown the same magnitude of response and are also limited by their toxicity.8 Recently, several anti-angiogenesis drugs, including sunitinib, sorafenib and bevacizumab have dem...

GSK's Pazopanib shows positive results in patients with advanced renal cell carcinoma

...le complete remissions observed in 7% of patients, toxicity has limited its widespread use. Lower dose cytokine therapies have not shown the same magnitude of response and are also limited by their toxicity.8 Recently, several anti-angiogenesis drugs, including sunitinib, sorafenib and bevacizumab have dem...

Brain-boosting pill alleviates post-chemotherapy fogginess

...t the University of Rochester is investigating the toxicity of cancer-killing drugs on healthy brain cells. In 2006 they showed that chemotherapy disrupts cell division in the hippocampus, the brain region essential for learning and memory. Until now, cancer patients had few options. Some studies have teste...

MU researchers find mechanisms that may unlock answers to Alzheimer's disease

... we dont know how toxic it is or at what stage the toxicity begins. In the past five years, we have started to understand how this disease works. With the new grant, we will be able to go forward and see if there are treatments that can modify the cellular response in the brain. The abnormal A-beta impairs ...

Benefits of trastuzumab are lasting, reducing both HER2 + breast cancer deaths and recurrence

...rapy group, she says. We have learned that cardiac toxicity that might result from trastuzumab can be managed in most cases, she says. Dr. Perez says that continuing follow-up is needed to continue to define the long-term benefit of using trastuzumab in these patients. Trastuzumab was approved for the tr...

UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells

...ot only dilute the potency of the drugs but create toxicity as well. In a paper scheduled to be published in the nanoscience journal Small in June, researchers from UCLAs California NanoSystems Institute and Jonsson Cancer Center report a novel approach using silica-based nanoparticles to deliver the antica...

Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans

...Council to develop a new approach and strategy for toxicity testing. The report recommends an approach that ...cifically, the new testing approach would focus on toxicity pathways -- cellular pathways that, when sufficiently perturbed, are expected to lead to adverse hea...

Environmental inequality study finds no direct links to segregation, income

...Using a measure of air pollutant concentration and toxicity developed by the Environmental Protection Agency to calculate the air pollution "burden" of each neighborhood in each metropolitan area, Downey compared levels of inequality between blacks and whites, Hispanics and whites, and Hispanics and blacks. H...

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