Discovery of T-cell 'traffic control' boosts new drug promise
... S1P function and slows the rush of T cells to the transplantation site without blocking normal immune response against bacteria and other infectious agents," he says. Similarly, such a drug should slow the autoimmune response that occurs in MS, a hypothesis recently confirmed in phase 2 clinical trials, he says. Su...Largest study of unrelated bone marrow transplantation for leukemia serves as benchmark
...kemia and related disorders undergoing bone marrow transplantation from unrelated donors. The study was designed to ...disease is a common complication after bone marrow transplantation in which the immune cells from the donated marrow attack the body of the patient who received the tr...Trial at Jefferson shows new drug may help cancer patients who need stem cell transplants
...tem cells available for transplantation. Stem cell transplantation entails collecting certain types of cells known as...amaged if not destroyed by treatment. Stem cell transplantation is considered "front-line therapy for multiple myeloma, or cancer of the bone marrow, and for high-r...Scans may help pin down tricky diagnosis
...n include liver transplantation, while bone marrow transplantation may be indicated for acquired monoclonal immunoglobulin light-chain amyloidosis. This small trial is the first assessment of scintigraphy in patients with cardiac amyloidosis. Intravenous solutions containing a radioactive isotope (99mTc-DPD) were gi......nd health care. Dr. Morell will present on cardiac transplantation for the management of hypoplastic left heart syndrome, while Dr. Munoz will speak on pre-operative management of hypoplastic heart syndrome. Hypoplastic left heart syndrome is a combination of several abnormalities of the heart and great blood vessel...Heart disease patients face greater risk of PTSD
...ck), sudden cardiac arrest, cardiac surgery, heart transplantation or congestive heart failure. The studies reported either an absolute number of PTSD cases among the patients or a prevalence rate -- how often the condition occurred within a larger group -- for PTSD. Among the 25 studies reviewed, the prevalence of ...Kidney transplant patients face higher cancer risk
...ma. Patients taking immunosuppressants after organ transplantation would be assumed to be at higher risk for cancers. Studies show that this holds true for nonmelanoma skin cancers but do not agree for melanoma risk. The baseline low incidence of melanoma in the general population may contribute to conflicting data....New blood transplant method stops fatal side effect, Stanford study finds
...ommon treatment for blood cancers. Blood stem cell transplantation replaces the cancerous blood cells of a leukemia o...phoma patient with those from a healthy donor. The transplantation cures the cancer, but in up to 80 percent of the cases there is a potentially deadly side effect: Th...Kidney transplant patients face higher skin cancer risk
...tes increased risk for patients who undergo kidney transplantation and who receive long-term immuno-suppression. Furt...hat patients taking immunosuppressants after organ transplantation to be at higher risk for all cancers, but disagree that there is a link to higher risk of skin cance...Use of kidney paired donation for incompatible donors could expand donor pool
...dividual organ recipients who undergo a successful transplantation have greatly improved expectations compared with t...ipients derive from a successful transplant, organ transplantation raises numerous ethical issues involving protection of the donor, informed consent, and equity in or...End-stage renal disease incidence, prognosis improving for patients with diabetes
...etes until development of ESRD (dialysis or kidney transplantation as identified from the Finnish Registry for Kidney Diseases), death, or end of follow-up on December 31, 2001. The median follow-up time after diagnosis was 16.7 years, with a maximum of 37 years. During the follow-up period, there were 632 cases of ...UK liver services need urgent improvement
...learly, specialised services for liver disease and transplantation will have to improve substantially to meet the considerably increased burden of liver disease that is predicted for the next 20 years, he concludes....Rapid restoration of immunity in immune-suppressed cancer patients using T-cell vaccines
... this form of cancer is high-dose chemotherapy and transplantation of one's own blood-producing adult stem cells; how...up received an initial pneumococcal vaccine before transplantation and chemotherapy, then a T-cell vaccine immediately after; a second group received the pneumococcal ...New clues into causes of scleroderma
...nts that were pre-treated with paclitaxel prior to transplantation significantly suppressed the activity of TGF-beta and lessened the formation of fibrotic tissue," Dong said. Just as importantly, the researchers said, the mice that received the skin samples from scleroderma patients exhibited the beginning of new b...HIV-positive patients have shorter survival periods while awaiting liver transplants
... and facilitate excellent outcomes following liver transplantation in this deserving group of recipients."...Regional disparities in transplantation rates
...may be eligible for kidney transplantation. Kidney transplantation is the treatment of choice for ESRD because it pro...is, there is marked regional disparity in rates of transplantation across Canada. This document provides detailed guidance on eligibility across broad criteria such as...Scientists use stem cells to grow cartilage
...ls. This could allow doctors to grow cartilage for transplantation for a number of injuries and medical problems, including sports injuries, new cartilage for people having hip replacements, and even for cosmetic surgery. Dr Archana Vats, from Imperial College London and first author of the paper, said: "The ability...Bluhm Cardiovascular Institute surgeons implant heart pump in comparative study of two devices
...otally implantable device will be available. While transplantation can be very effective for end stage heart disease, only 2000 are done annually in the United Sates and the number who could benefit from replacement therapy may be as many as 250,000. However, currently destination therapy is available only to those ...Liver transplants may not be indicated for cystic fibrosis patients with bleeding complication
...s in these patients. "There is no doubt that liver transplantation has a role in the management of end-stage liver disease due to CF," Dr. Jonas concludes. "However, the data presented by Gooding et al. suggest that perhaps it should be limited to those patients who have evidence of true hepatocellular dysfunction a......tigen 1 (LRH-1). Following hematopoietic stem cell transplantation in a patient with chronic myeloid leukemia, the authors observed a massive rise in the number of LRH-1specific T cells that coincided with remission of leukemic disease. The authors found that, in the transplant recipient, the P2X5 gene (which codes ...