Tag: "transporter" at medical news

Nature publication reports key links between mechanisms of aging and metabolic disorders

..., and 4) INDY ('I'm not dead yet'), a cell surface transporter known to increase lifespan in flies when mutated. Dr. Kopchick stated, "The article by DiStefano et al. will stimulate a paradigm shift in our thinking about aging and age-related disorders. As pointed out by the authors, we are beginning to recogni...

Study identifies fat-secreted protein linked to insulin resistance

...had focused on understanding the role of a glucose transporter protein called GLUT4 in the development of insulin resistance. Knowing that downregulation of GLUT4 expression in fat tissue is an almost universal feature of insulin-resistant states (including obesity, type 2 diabetes and the metabolic syndrome), p...

Mayo Clinic researchers invent 'hitchhiking' viruses as cancer drug delivery system

...r showed that once it reached the tumor, the viral transporter successfully transferred a gene to both mouse and human tumor cells that then infected the cells. This proved that the concept works. Collaboration and Support In addition to Dr. Vile, the Mayo Clinic research team included Caroline Cole, Ph.D.; Ji...

JCI table of contents: December 1, 2005

...ausanne demonstrate that expression of the glucose transporter type 2 (GLUT2) in glial cells of the brain, but no...TITLE: Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors AUTHOR CONTACT: Bernard Thorens University o...

Evidence links cocaine abuse and Parkinson's disease

... them in those neurons. Specifically, the ratio of transporter proteins to the sacs increased by 27 percent in th... the investigators reported. "This means that the transporter proteins were pumping more dopamine back into the pre-synaptic nerves than could be repackaged in th...

Drug aimed at Huntington's eases chorea, the disease's hallmark feature

...e inhibits a molecule known as vesicular monoamine transporter 2 (VMAT2), an action that ultimately blocks the release of dopamine. This is not a wonder drug for Huntingtons. It doesnt address the psychiatric or cognitive problems, for instance. But there are some patients for whom chorea is clearly a devastatin...

Delayed-release stimulant used to treat ADHD may be less subject to abuse

...ET scans which showed whether or not the dopamine transporter molecule was occupied by the medication were take... maximum blood levels and blockade of the dopamine transporter than did the immediate-release drug. While most of those receiving immediate-release methylphenidat...

Dying of excitement

..., is a mutation in the gene encoding the glutamate transporter protein EAAT2. This mutation --- a single nucleotide change in the promoter region of the EAAT2 gene -- was equally prevalent in healthy individuals and stroke patients. But among stroke patients, those with the mutated allele had higher plasma leve...

Yale researchers identify gene depth protects against kidney stones

...hat abnormal expression or regulation of the anion transporter encoded by the gene could cause kidney stones in humans, although this has not yet been tested directly....

Transporter is possible target for safer pain medicine

A transporter that silences one of the body's natural pain kille...g Abuse, he is working to clone the opioid peptide transporter he identified three years ago and identify the responsible gene and protein. Interestingly he also h...

NIDCR's Turner to receive IADR Salivary Research Award

...ch he and his colleagues established as the single transporter responsible for the vast majority (~70%) of salivary fluid secretion. The body of work generated by his research group includes kinetic, regulatory, and structural studies. Thanks to their efforts, we know how important NKCC1 is to salivation, how to...

Johns Hopkins lab scientists tame overactive CF protein

... 97 (valosin containing protein), kills a chloride transporter in the cells of the vast majority of CF patients, but quieting the protein restores the cells' ability to transport chloride in and out, researchers found. The inability to transport chloride is the hallmark of CF that causes dangerous buildup of thi...

Serotonin receptor: A rheostat in brain for emotion that may be linked to depression

...mechanisms underlying the effects of the serotonin transporter gene variation on amygdala reactivity. "Antidepressants, especially the SSRIs, which increase the availability of serotonin, may actually be working by shifting the availability of 5-HT1A autoreceptors and, as a consequence, modulating the reactiv...

Navigable nanotransport

... species that are recognized by cells, showing the transporter the way to reach its goal, such as a tumor cell. To demonstrate the power of their new concept, Kim and his team chose rigid, disk-shaped monomers equipped with a ring of special molecular "hooks" that can be activated by UV light. When a solution c...

JCI table of contents: May 1, 2007

...vestigation, show that mice lacking organic cation transporter 1 (OCT1) have reduced effects of metformin on AMPK... Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action AUTHOR CONTACT: Kathleen M. Giacomini University of California San...

OCT1 required for therapeutic effects of diabetes drug Metformin

...vestigation, show that mice lacking organic cation transporter 1 (OCT1) have reduced effects of metformin on AMPK phosphorylation and a decreased ability to control glucose levels. The authors also identified seven mutations in OCT1 in humans that reduce metformin uptake. These studies indicate that OCT1 is impo...

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