Split the difference: Pill-splitting study looks at cost-saving step that could be used by millions
...s also the first prospective randomized controlled trial of pill-splitting, and the first to look at the im...m, 111 patients agreed to participate in a 6-month trial of pill splitting in which half were randomized to receive a financial incentive of 50 percent reduc...UK scientists set their sights on cure for AMD
...ular Degeneration (AMD) is to be taken to clinical trial by scientists and clinicians at the UCL Institute of Ophthalmology, Moorfields Eye Hospital and the University of Sheffield. The therapy, using cells derived from human embryonic stem cells to replace the faulty retinal cells that cause AMD, will be ...GSK announces launch of largest ever Phase III trial in lung cancer treatment
...al results of a Phase II proof-of-concept clinical trial of its investigational MAGE-A3 Antigen-Specific Ca...g in Chicago, Illinois, [Abstract No: 7554]. Final trial analysis showed a 27% reduction in the relative risk of cancer recurrence following surgery in patie...Folic acid supplements do not appear to reduce risk of colorectal tumors
...sons with a history of these types of lesions. The trial was conducted at nine clinical centers in the U.S....nearly impossible." "The results of the clinical trial by Cole et al illustrate, yet again, the principle that chemoprevention with single agents is proble...New drug shows promise in treatment of advanced thyroid cancer
...rs continue to grow. Another 18 patients left the trial for other reasons, including toxicity. Five of th...t had severe fatigue and only one patient left the trial for this reason. Axitinib also caused hypertension in about 28 percent of patients and a range of d...Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
...al Oncology in Chicago. The results of the 65-site trial also showed that those patients who underwent chemotherapy and whose CTC number went down fared better and had a more favorable prognosis. That is, the level of response to chemotherapy was reflected in the CTC level, notes Dr. Moreno. The numbers he...Research shows survival benefit for leukemia patients treated with arsenic trioxide
...nd their physicians to participate in the clinical trial has markedly improved the outcome for participants and future patients with APL. Study participants underwent extensive follow-up (32 months on average), including weekly blood tests and regular bone marrow tests. Arsenic trioxide appeared to be we...Benefits of school-based fitness programs fade after summer
...ison, previously conducted a randomized controlled trial in which 17 overweight children were assigned to participate in a lifestyle-focused, fitness-oriented physical education class for nine months. At the end of the trial, students in the class achieved significant improvements in cardiovascular fitness...Stanford researchers track human stem cells transplanted into rat brain
... were similar to those that are part of a clinical trial for a childhood disorder called Batten's disease. Steinberg said he and others are interested in testing these or other stem cells as a way of treating a wide range of diseases....Hot flashes may be welcome sign in women with breast cancer, study says
...g and Living (WHEL) study a multi-site randomized trial of the impact of a diet high in vegetables, fruits and fiber, and low in fat on the recurrence of breast cancer. The WHEL participating institutions are University of California, San Diego and Davis, Stanford University, Kaiser Permanente in Oakland ...Snoring in children might be an allergic type disease
...a Prevention Study (CAPS) a randomised controlled trial of dietary intervention and house dust mite avoidance during the first five years of life. 219 children within the original study group had rhinitis and of these, 213 could provide information on snoring. Almost 60% of these children snored at lea...International journal group updates guidelines on registration of clinical trials
...ly 1, 2008. This definition states that a clinical trial is any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. The ICMJE will not consider results posted in the same clinical trials...Revlimid data presented at ASCO stands to change the way physicians treat multiple myeloma
... the ECOG study were reported last month, when the trial closed early based on one-year data which showed a...ded that it was best to switch all patients in the trial onto the lower dose. However, for the first time at ASCO, the complete data were presented and sho...Drug shows activity against brain metastases
... breast cancer, according to results of a clinical trial being presented by Dana-Farber Cancer Institute sc... Sunday, June 3, at 11:15 a.m. (N Hall, B1). The trial examined the tolerability and efficacy of lapatinib in a Phase II study that included 241 patients w...Herceptin does not increase heart failure in patients long term
...Surgical Adjuvant Breast and Bowel Project (NSABP) trial B-31, presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. Based on the findings, the research team developed a prediction model to help oncologists assess the risk of heart failure in individual breast canc...Brain-boosting pill alleviates post-chemotherapy fogginess
...ast cancer, participated in an eight-week clinical trial testing the effects of modafinil (Provigil). All women took the drug for the first four weeks. During the next month half of the women continued to receive the drug while the other half took an identical looking placebo pill. The women who took modaf...Vorinostat shows anti-cancer activity in recurrent gliomas
...n overall survival of the patients enrolled on the trial was 5.7 months -- similar patient populations enrolled in prior NCCTG trials had a median overall survival of between 4 and 4.4 months." This study was the first application of vorinostat in targeting brain cancer. Vorinostat is approved by the U.S. ...Nonhormonal drug reduces hot flashes in men treated for prostate cancer
...223-patient, placebo-controlled Phase III clinical trial at the 2007 annual meeting of the American Society...es in men, where results from a placebo-controlled trial are positive enough to support that a nonhormonal medication can be used to help some of our patient...Phase II study shows combination improves survival of metastatic melanoma patients
...(ASCO) Annual Meeting. In this phase II clinical trial of 53 patients, tumor growth was delayed by almost six months, whereas, typically, these cancers begin spreading again eight weeks after chemotherapy treatment, researchers say. The researchers from Mayo Clinic ( http://www.mayo.edu/ ) and the Nor...Pre-operative chemotherapy does not increase survival rates for nonsmall cell lung cancer
...tive] chemotherapy. Combining the result of this trial with previous trials suggests use of neo-adjuvant chemotherapy results in a relative increase survival benefit of 12% and an absolute survival benefit of 5% at five years. The authors conclude: Although there was no evidence of a difference in over...