Gene variations point to why lung cancer drugs work better in Japanese vs. US patients
...ls groups in Japan. Gandara, who leads lung cancer trial efforts for the Southwest Oncology Group, is direc...rugs paclitaxel and carboplatin in a SWOG clinical trial and one conducted by the Japan Multicenter Trial Organization. In the trials, half the Japanese pati...Herb shows potential to reduce cancer-related fatigue
...d emotional well-being. Because this was a pilot trial designed to pinpoint which aspects of fatigue gins...Bartons research team hopes to open a new clinical trial in 2008 looking at a specific dose of Wisconsin ginseng versus placebo and trying to better refine t...VEGF Trap shows activity in patients with advanced ovarian cancer
...ry results of a randomized, international Phase II trial of VEGF Trap (aflibercept) show activity in patien...o have exhausted all other options. To date, the trial has enrolled 162 patients with advanced ovarian cancer at 44 centers in twelve countries in Europe, ...Shark cartilage shows no benefit as a therapeutic agent for lung cancer
...u. "This is the first large Phase III randomized trial of shark cartilage as a cancer agent. A unique and...ns can point to this large NCI-sponsored Phase III trial and tell patients that, at this point, the only studies that have been done with cartilage-derived p...Dasatinib shows high early response rate as first treatment for chronic myelogenous leukemia
...ccording to early results from a Phase II clinical trial at The University of Texas M. D. Anderson Cancer C...y in Chicago Saturday June 2nd, 2007. The clinical trial remains in progress with 35 patients enrolled. Dasatinib, known commercially as Sprycel and produc...Radium-223: An alternative treatment for prostate cancer
...23 has delivered promising results in a randomised trial to test its efficacy in treatment of hormone-refractory prostate cancer (HRPC). The findings are reported early Online - timed to coincide with presentation of the paper at the American Society of Clinical Oncology meeting in Chicago and in an upcom...Study supports activity of GEMZAR in the treatment of early-stage breast cancer
...rials.gov . More About ASCO Abstract # 595 The trial enrolled stage II-III breast cancer patients (with a median age of 45), including inflammatory tumors, a type of breast cancer that causes the breast to swell, redden and feel warm. Of the 73 patients enrolled in the study, 42 (57.5%) were classified...Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
...t ASCO from a Phase II, open-label, non-randomized trial will report on an International Oncology Network Study evaluating the safety of a triplet therapy in which bevacizumab (Avastin) was added to the combination of ALIMTA plus oxaliplatin (Eloxatin) in patients with advanced NSCLC (Abstract # 7700 ). Pr...Mouse model points to possible new strategy for treating rare muscle disease, kidney disorders
...globulin. NHGRI researchers expect the clinical trial of ManNAc for HIBM to begin in late summer or early fall. Based on their findings, the group is also exploring the possibility that ManNAc may benefit people suffering from diseases that involve damage to the cell layers of the kidney that are requir...Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
...participating in a phase III randomized controlled trial comparing two different chemotherapy regimens. One hundred and seventy patients (92 percent) had evidence of HBV infection. Of these, 125 had sera available to determine HBV DNA levels and were included in the study. For each patient, the research...Study tests oral insulin to prevent type 1 diabetes
...up of people at risk for the disease. An earlier trial suggested that oral insulin might delay type 1 dia...may be eligible to participate in the oral insulin trial or future studies that try to arrest the autoimmune process. To lower blood sugar levels once diab...OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
...lled in the ASCENT study, a large Phase 2 clinical trial that evaluated treatment with docetaxel and DN-101...Oncology. . The most significant finding from the trial of advanced prostate cancer subjects was the magnitude of DN-101 (Asentar) used in combination with ...Lilly studies try to shed light on impact of race
...survival data from a previous randomized Phase III trial in the treatment of NSCLC, viewing data outcomes a...frican-Americans compared with 906 Caucasians. The trial was designed to compare the efficacy of GEMZAR plus carboplatin with GEMZAR plus paclitaxel and a re......r research version, rather than a beta - ready for trial use in the field. As an example problem, the ISI team is now working to integrate into RAW risk analysis resources used in foot and mouth disease research being undertaken at one of the other centers, the Center for Foreign Animal and Zoonotic Dis...Study: Directly observed HIV therapy for children is promising
...atch said, are to conduct a randomized, controlled trial to compare directly observed therapy with standard care as well as to conduct a rigorous cost-benefit analysis. We need to know what works in treating children in resource-poor settings so we know where to put limited HIV treatment dollars, he said....New biodegradable magnesium stents for coronary arteries
...rough the body's natural processes. However the trial also showed that angiographic restenosis (re-blocking of the artery) occurred in 47.5% of patients who received the biodegradable stents, and 27% needed target lesion vascularisation within 12 months due to recurrent ischaemia (lack of blood flow to ...Society for Prevention Research meeting May 30-June 1, Washington, D.C.
...rams aimed at parents help" An ongoing population trial aimed at strengthening parenting and reducing risk for child maltreatment involving 18 counties each between 50,000 and 175,000 in population has seen promising results relative to reported child maltreatment rates and out-of-home placements.All stor...Second SPORT study shows surgery advantage for spinal stenosis and slipped vertebra
...omized changed their minds after enrollment in the trial and switched to the other group, i.e. choosing to have surgery after being randomized to the non-operative group, or deciding to proceed non-surgically after being randomized to the surgical group. As a result of the substantial crossover between su...How brain pacemakers erase diseased messages
...ice," he said. "Therefore, it might take months of trial and error to find the optimal setting." Grill's new model promises to streamline the process. ...Doctors conclude temsirolimus is effective new treatment for advanced renal cell carcinoma
...e metastatic disease. Only a randomized, clinical trial will give us that definitive knowledge." Temsirolimus was better tolerated than interferon. Fewer patients treated with temsirolimus had grade 3 or 4 (severe) side effects compared with those treated with interferon or the combination of interfe...