1 of 2 pediatric kidney disease research centers in world established
...ltimately to new diagnostic tests and new clinical trials for specific therapies in children with genetic and acquired kidney diseases which lead to progressive loss of kidney function. Michael Dunn, M.D., dean and executive vice president, whose research focus is kidney disease, says, The Center will draw...Reanalysis of controversial meta-analysis says writing off rosiglitazone may be premature
... Dr. Steven Nissen and Kathy Wolski of 42 clinical trials involving 27,847 patients for whom rosiglitazone w...l Center,concludes "that only prospective clinical trials designed for the specific purpose of establishing the cardiovascular benefit or risk of rosiglitazon...Pathway links inflammation, angiogenesis and breast cancer
... and similar mTOR inhibitors are in early clinical trials for a number of cancers at M. D. Anderson and elsewhere. One drug, temsirolimus, has been approved to treat renal cell carcinoma. Hung's lab is exploring the possibility that this TNFa-driven activation of mTOR is the molecular link between obesity...Chemotherapy with bevacizumab increases risk of blood clots in arteries
...gues analyzed data from five randomized controlled trials that included 1,745 patients with metastatic colorectal, breast, or nonsmall-cell lung cancer. Among patients treated with the combination therapy, 3.8 percent experienced blood clots in their arteries, compared with 1.7 percent of patients on che...Miniature implanted devices could treat epilepsy, glaucoma
... researchers for epilepsy currently is in clinical trials at several sites, including the Indiana University... Purdue researchers are planning to conduct animal trials by December and human trials within 18 months. The device is fully implantable and includes a batter...Early-childhood intervention may improve well-being through young adulthood
... so strong that we dont need randomized controlled trials to sort out these details; but with the quality of currently funded preschool programs so far below the standards embodied in the model programs on which the case for expanded preschool is based, we will need extraordinarily strong evidence to ensure...ACC/AHA release revised UA/NSTEMI guidelines
... the last several years. New evidence from pivotal trials over the past five years has been gathered togethe...o longer recommended because results from clinical trials have shown no benefit and possible harm. There is also a greater emphasis on smoking cessation. ...Annals of Internal Medicine tip sheet for Aug. 7, 2007, issue
...ersy will only be solved with prospective clinical trials designed for the specific purpose of establishing the cardiovascular benefit or risk of rosiglitazone. (This Perspective piece is published early online by Annals of Internal Medicine at www.annals.org. Authors appeared before the FDA advisory pane...Trial stops after stroke and mortality significantly reduced by blood
... mortality in the over-80s. A number of earlier trials had demonstrated that reducing blood pressurein the under-80s reduces stroke and cardiovascular events. However,previous smaller and inconclusive studies also suggested that whilstlowering blood pressure in those aged 80 or over reduced the number of...Statin drugs may delay progressive artery damage in children
... remains unknown and will require further clinical trials to resolve, Vissers said. We intend to continue t....S. Food and Drug Administration based on clinical trials performed in children with FH....Shining light on pancreatic cancer
... The next stages of the pancreatic cancer research trials incorporate some examinations that are biopsy-free... from ENH and an expert on pancreatic cancer. In trials that began before the pancreas research, the researchers saw encouraging results with colon cancer d...Method shows promise for early detection of pancreatic cancer
...at the Feinberg School, who is overseeing clinical trials at Evanston Hospital. (Roy also is a collaborator on the pancreatic cancer work.) The results in our colon cancer work, in which measurements are taken from the rectum, led us to wonder if we could use tissue taken from the duodenum to screen for p...Trials underway for 'essential' new TB vaccine
Clinical trials are underway with the first new vaccine against TB...em for the protein and the results of the clinical trials to date show the highest T cell responses ever induced with a vaccine. "This vaccine is safe and ...New algorithm matches any tumor cells to best possible anti-cancer treatments
... should greatly lower the failure rate of clinical trials testing new compounds. Likewise, as the drug disco... compounds. Dr. Theodorescu is planning clinical trials for the new compounds against bladder cancer. Another planned clinical trial would examine patients ...Should adult male circumcision be recommended for HIV prevention in the US?
Three clinical trials in Africa found that adult male circumcision reduc...among men who have sex with men (MSM). The African trials did not study MSM. While some observational studies have suggested that circumcised MSM in the US ma...Helicopter flight trials for EGNOS
Successful trials have recently been conducted at Lausanne, Switzerl...al service landing pad in the city. The Lausanne trials were performed by Eurocopter, using their EC155 experimental all-weather helicopter (Hlicoptre Tous ...Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
...omised controlled trials. Data from seven of these trials were available from trial reports and were combined in a meta-analysis. The seven trials involved a total of 988 patients. This is currently the best estimate of the effectiveness of this...Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
...dical literature, they drew on data found in eight trials that together involved a total of 9598 people who had AF but had not suffered stokes so far. The results showed that anticoagulants were more successful than anti-platelet therapies at reducing stroke. They reduced the risk of a stroke in people wi...Sucampo Pharmaceuticals submits supplemental new drug application for Lubiprostone to treat IBS-C
...er, double-blinded, randomized, placebo-controlled trials involving 1,171 adults, followed by one long-term, open-label safety and efficacy extension trial involving 522 adults diagnosed with IBS-C. In the two Phase III studies, patients received lubiprostone 8 mcg taken twice daily (783 adults) or placebo...