Basic research leads to a novel cancer therapy
...e vascular endothelial growth factor (VEGF), which triggers blood vessel development. Ullrich found some of the most important evidence in research on animals, conducted with colleagues Birgit Millauer and the late Werner Risau, formerly of the Max Planck Institute of Neurobiology. There is a receptor specifi...Worldwide study looks to find causes of type 1 diabetes
... Institutes of Health to investigate environmental triggers of the disease that turn the body's immune system ...oot and mouth disease) that have been suggested as triggers for type 1 diabetes. But the literature is very controversial: some studies are for it, some are aga...Preventing toxic side effects of inflammatory disease therapy
... autoimmune diseases, however, this defense system triggers an inflammatory response when there are no foreign substances to fight off, or the defense system goes into "overdrive" and forgets how to turn off. In these diseases, the body's normally protective immune system attacks and damages its own healthy ...JCI table of contents: January 19, 2006
....org/article.php?id=25964 IMMUNOLOGY TLR2 both triggers and tames the immune response It is an established premise that invading pathogens release antigens that bind to Toll-like receptors (TLR ligands) on the surface of various cells of the immune system. This event stimulates specialized immune cells ...Sequence-based early warning system for the detection of MRSA outbreaks in hospitals
...e integrated with epidemiological information, and triggers an alarm if an outbreak is suspected. This approach was more sensitive at identifying outbreaks than classical surveillance techniques. The combination of medical informatics and molecular laboratory techniques could help clinicians prevent limited ...Loss of caspase-8 makes neuroblastoma more aggressive
...January 5 issue of the journal Nature. Caspase-8 triggers apoptosis by binding to molecules called integrins...ti said. The binding of caspase-8 to integrin then triggers integrin-mediated death (IMD), a form of apoptosis. "Cells aren't usually supposed to break away f...Hopkins researcher links gene mutation with poor outcomes in people with most common thyroid cancer
...opkins have found that a mutation in the gene that triggers production of a tumor growth protein is linked to poorer outcomes for patients with papillary thyroid cancer (PTC). A report on the study is published in the December issue of The Journal of Clinical Endocrinology and Metabolism. Mingzhao Xing, M.D....Cell stress protein linked to aggressive breast cancer
... which normally protects cells from stress damage, triggers events that may cause breast cancer when overactive. Breast cancer is the most common cancer in women and is responsible for over 400,000 deaths annually in women throughout the world. Most of these deaths are the result of aggressive breast tumors ...Enzyme triggers plaque rupture in hardened arteries, causing heart attack and stroke
...plaque buildup in narrowed coronary arteries, that triggers plaque rupture. This rupture can cause blood clots and block blood flow to the heart and brain, causing a heart attack or stroke. The results appear online on December 22 in advance of print publication in the January 2006 issue of the Journal of Cli...Adults also suffer from cyclical vomiting syndrome
Migraines and panic attacks may be the triggers for Cyclical Vomiting Syndromein adults, according a small study published today in the open access journalBMC Medicine. Cyclical Vomiting Syndrome (CVS), widely accepted as occurring inchildren, is also found in adults according to researchers. Davi...Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
...ve discovered how to block a molecular switch that triggers brain damage caused by the lack of oxygen during a...cientists showed that stimulation of EP1 receptors triggers the damage caused when blood flow is suddenly restored after a stroke. The team blocked blood flow i...TRAF3 protein is a key part of the early immune response to viruses
... cells, is actually a key part of a mechanism that triggers release of anti-virus molecules called type I inte...h produced pairs of MyD88-gyrase B complexes, then triggers recruitment of the rest of the army of proteins that form the macrophages's signaling pathway, accor...Alzheimer's disease prevention may be easier than cure
...er time of amyloid beta peptide 142 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease. The reduction of amyloid levels is therefore a major therapeutic objective. Todd Golde and colleagues from the Mayo Clinic Jacksonville report evidence to suggest that pr...JCI table of contents: December 8, 2005
...er time of amyloid beta peptide 142 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease. The reduction of amyloid levels is therefore a major therapeutic objective. Todd Golde and colleagues from the Mayo Clinic Jacksonville report evidence to suggest that pr...Inflammation linked to chronic pain: Study
... impulse up the spine and to the brain. The signal triggers receptors called glutamate AMPA and kainate, which...ysiology of the cells. When the painful event also triggers inflammation, the nerves send extra information to the normally dormant NR2B receptors receptors th...Researchers uncover clues to vitamin A resistance in lung cancer
...xpression. "Combining a retinoid with a drug that triggers expression of RAR1 would form a new approach for treating patients with lung cancer," said Petty, an assistant professor of hematology and oncology at Wake Forest's School of Medicine, which is part of Wake Forest University Baptist Medical Center....A recipe for overeating: Studies outline dangers of mixing stress, deprivation and tempting foods
... a bite of highly palatable (often forbidden) food triggers binges and makes it difficult to abstain from binge eating." The researchers speculate that the deprived and stressed rats may have been in a "hedonic deprivation state," essentially craving something good and rewarding. The research underscores ...Gas-blockers might slow down Alzheimer's disease
...ty Weill Medical College found that an enzyme that triggers the production of nitric oxide (NO) -- a gas that helps immune cells fight off invading pathogens -- accelerates the formation of brain lesions in Alzheimer's-prone mice. The study suggests that inhibitors of this enzyme (called iNOS) -- which have ...Broccoli sprouts, cabbage, ginkgo biloba and garlic: A grocery list for cancer prevention
...e finding demonstrates for the first time that DAS triggers a gene alteration in PhIP that may play a significant role in preventing cancer, notably breast cancer, induced by PhIP in well-done meats. Thomas noted that no studies have shown a link between cooking vegetables and fruits and PhIP, regardless of...Be a control freak: Allergists outline new focus for asthmatics
...n of the diagnosis of asthma, assessment of asthma triggers (including allergy) and individualized treatment. Well-controlled or excellent control of asthma is defined by the paper's authors as follows: Asthma symptoms twice a week or less Rescue bronchodilator used twice a week or less No night or early m...