Two drugs combined more cost-effective safer for managing arthritis in high-risk patients
...t can cause gastrointestinal complications such as ulcers and hemorrhages in high-risk patients. The UCLA study found that for high-risk patients, it is more cost-effective and safer to use a non-steroidal anti-inflammatory drug combined with a proton pump inhibitor, which is an acid-lowering drug, compare...UBC-U of S research offers hope for treatment of age-related blindness
...SAIDS can have side effects such as stomach upset, ulcers and stress on kidneys, they are not appropriate for everyone and criteria for high-risk patients that would benefit from their use will need to be defined. Macular degeneration is the most common cause of severe vision loss in Canada, especially amon...Mayo Clinic study determines surgery is best remedy for hammer hand
...nts feel their hands are warmer right away, though ulcers take a little longer to heal," he says. "Most peop...to the sensory damage, they also can develop small ulcers in their fingertips resulting in blackened fingers or even gangrene, due to lack of oxygenation. "M...Study compares stomach acid control of three proton pump inhibitors in chronic NSAID users
...ibitors have been shown to reduce the incidence of ulcers associated with chronic NSAID use," said Jay L. Go...dicated for reducing the risk of gastric (stomach) ulcers developing among at-risk patients on continuous NSAID therapy. Patients are considered to be at risk...Biologic therapies for bowel disease show promise in clinical trials
...ve colitis, a disease that causes inflammation and ulcers in the superficial layers of the large intestine. The standard first- and second-line therapies, 5-ASA agents and corticosteroids, are not effective in all patients and are often associated with severe side effects. While the use of anti-tumor necr...Study shows grapefruit extract can heal stomach ulcers
...s. For the study, investigators induced gastric ulcers in rats and applied graded doses of GSE (2-20 mg/k... and a progressive decrease in the area of gastric ulcers by days six and nine of treatment. The treatment also prompted a significant rise in blood flow at ...Benefits of continuous NSAID use in ankylosing spondylitis
...ssion of AS, without increasing the risk of peptic ulcers or other adverse events. The clinical trial began with 215 outpatients, drawn from the records of 76 hospitals and private practices in France, with a history of AS. Using a computer-generated randomization list, the patients were divided into two t...Researchers shed new light on cause of bedsores and other chronic wounds
...dsores -- also known as pressure sores or pressure ulcers -- have been estimated to affect about five to ten percent of hospital patients, 13 percent of nursing home residents, and up to 39 percent of spinal cord injury patients in the United States. Chronic wounds can lead to widespread infections and limb...Giving oxygen may do more harm than good, new report shows
...ing difficult birth procedures; and treating foot ulcers and gangrene in people with type 2 diabetes. Dr. Iscoe hopes to evaluate the promise of the new technique in a study of diabetic patients. As the incidence of obesity rises, diabetes is expected to affect a growing number of people and exert increas......xidant and neutrophil killing, and produced larger ulcers when injected into the skin of normal mice. "The discovery of the critical role played by golden pigment in protecting against infection provides an novel target for treatment of serious Staph infections including those produced by antibiotic-resista...Three deadly parasite genomes sequenced
...so known as "Baghdad boil," produces numerous skin ulcers that can leave sufferers permanently scarred. Some 1,000 American service members have been diagnosed with cutaneous leishmaniasis according to testimony by Walter Reed Army Institute of Research's Alan Magill, M.D., at an Institute of Medicine meeti...Mental health following stroke, spinal cord injury; sensory evaluation tools
...n, is thought to play a role in the development of ulcers that can lead to infection and subsequent amputation. Investigators constructed a prototype shear and pressure sensor consisting of two arrays (top and bottom) of fiber optic cables sandwiched between three layers of gel insole. They demonstrated the...New study examines impact of nurse-patient ratios law
...nce of patient falls or the prevalence of pressure ulcers (bedsores), but they emphasized the preliminary nature of these findings and the limitations of the study, concluding that more research would be needed to determine the effect of mandatory staffing ratios on patient outcomes. In an accompanying edi...Findings relate aspirin-induced ulcers, hearing loss
...'s well known that high doses of aspirin can cause ulcers and temporary deafness, but the biochemical mechanism responsible for these phenomena has never been deciphered. New research from Rice University offers clues, showing for the first time how salicylate -- an active metabolite of aspirin -- weakens l...Chronic arthritis pain and the disappointment of u-opioid therapy
...so bring the risk of adverse effects, from stomach ulcers to heart attack. Recent studies have suggested the potential of tapping into the body's supply of painkilling peptides as a safe, natural approach to arthritis pain management. Extraneous substances such as morphine can be disadvantageous in arthrit...Researchers win Nobel Medicine Prize for discovering cause of ulcers
... nearly half a million people newly diagnosed with ulcers in the U.S., an annual cost to the health care sys...ning the role of H. Pylori in the development of ulcers and stomach inflammation has not only allowed gastroenterologists to offer more effective treatments...Which drugs should health plans cover?
...save money in the long run by reducing the risk of ulcers and intestinal bleeding. But that claim was not consistently demonstrated in randomized comparisons. The most recent evidence now finds that Cox-2 inhibitors probably do not reduce intestinal side effects and probably do increase risk of heart proble...High doses of ibuprofen cause significant GI bleeding, despite safety profile
...th the fewest side effects and lowest incidence of ulcers or GI bleeding. Everyday more than 30 million people take over-the-counter (OTC) and prescription NSAIDs for pain relief, headaches and arthritis. Although long-term use of NSAIDs in high doses can provide great benefit in terms of anti-inflammator...... lining. Without treatment, gastritis may lead to ulcers and in some cases, stomach cancer. Unlike the gree...tists who some years ago demonstrated that stomach ulcers are almost always caused by H. pylori infection, and that a course of antibiotics could cure most of...