GSK's Pazopanib shows positive results in patients with advanced renal cell carcinoma
..., either alone or in combination, have been widely used in patients with advanced disease. Although high-dose IL-2 has shown promise with durable complete remissions observed in 7% of patients, toxicity has limited its widespread use. Lower dose cytokine therapies have not shown the same magnitude of r...GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer
..., either alone or in combination, have been widely used in patients with advanced disease. Although high-dose IL-2 has shown promise with durable complete remissions observed in 7% of patients, toxicity has limited its widespread use. Lower dose cytokine therapies have not shown the same magnitude of r...Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
... regimen may deliver less toxicity than a commonly used therapy in advanced non-small cell lung cancer (NS... compare ALIMTA plus carboplatin with the commonly used regimen of GEMZAR (gemcitabine HC1 for injection) plus carboplatin (ASCO Abstract # 7517 ). The stud...Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
...his is translational work," says Dr. Scalia. "Weve used a mouse model to prove Adiponectin conceptually wh...ting atherosclerosis and vascular disease." They used a technique, intravital microscopy, which permits researchers to illuminate blood vessels using fluo...Mouse model points to possible new strategy for treating rare muscle disease, kidney disorders
...ed by the sequencing of the human genome are being used to uncover new strategies for treating genetic human disease, said NHGRI Director Francis S. Collins, M.D., Ph.D. This work also underscores the value of animal models in learning more about the pathways involved in human disease and how to target th......rth American desert shrubs have been traditionally used by Native Americans as healing remedies. The preliminary results, to be published in August in the journal Aging Cell, show that male mice fed a normal diet and NDGA so far have survived in significantly greater numbers than mice on a normal diet...VA tops private hospitals in infection-control study
...tals. Ninety-one percent of VA hospitals regularly used chlorhexidine gluconate as an antiseptic, compared... line changes. Only 44 percent of non-VA hospitals used this combination of techniques. "While we're seeing the use of some of these recommend...Study explains why patients with OSA are at higher risk for cardiovascular disease
... according to Dr. El Sohl. While CPAP is currently used to treat OSA, looking for circulating apoptotic endothelial cells as a marker to fine-tune the therapy is one potential application. This may potentially reduce OSA patients' risk of CVD. Dr. El Sohl mentioned that statins, angiotensin converting enz...Treatment outcomes of patients with HIV and tuberculosis
...ding was corroborated by a similar study that also used molecular genotyping as a relapse indicator. HIV-infected patients who received 6 months of rifamycin-based TB treatment or who were treated intermittently (one to three times per week), were four times more likely to have a reoccurrence than tho...OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
...cer subjects was the magnitude of DN-101 (Asentar) used in combination with docetaxel (Taxotere), on survival, producing an estimated 49 percent improvement in survival (p=0.035), while reducing the frequency of serious adverse events by 34 percent (p=0.023) as compared to the use of Taxotere alone. Bec...Brain inflammation may be friend, not foe, for Alzheimer's patients
... as lentiviruses for use in gene therapy. The team used a lentivirus to boost levels of IL-1 beta in select brain regions of its engineered mouse, then applied the technology in mice specially designed to develop Alzheimers disease. The mice developed normally for six months. Then Shaftel raised the lev......alysis Workbench, or RAW, which will ultimately be used at all eight DHS research centers, not just CREATE...a small, man-portable anti- aircraft rockets being used to bring down a passenger airline, tracking consequences out a "decision trees" of alternate possibi...Older motorists improve driving performance with physical conditioning
...ic conditions based on the driving evaluation form used by the CT DMV. Each item was scored zero for major problem, one for minor problem and two for no problem. Total scores ranged from zero (worst) to 72 (best). Participants who received the intervention increased their road test scores after three ...Study: Directly observed HIV therapy for children is promising
...eliver those doses themselves. This method, widely used to combat tuberculosis, is aimed at ensuring that people take their medications. That adherence will keep patients healthy and reduce the likelihood of drug resistance. Researchers evaluated HIV-infected children living in orphanages or with extend...Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates
...yringe delivery of vaccine at the same 0.5 mg dose used in the juvenile animals. Neutralizing antibody levels exceeded the accepted protection threshold prior to the second injection at Week 4, peaked at Week 8, and remained above the accepted protective level throughout the 20-week follow-up period. No a...Men worry more about penile size than women, says 60-year-old research review
...e and Eardley also looked at the bizarre practices used by men worldwide to enhance the size of their penis, including the Topinama of Brazil, who encourage poisonous snakes to bite their penises to enlarge them for six months! They report that Indian Sadhus men are known to use weights to increase th...Mayo researchers discover overdiagnosis of long QT heart syndrome
...ds for interpreting data obtained from heart tests used to evaluate LQTS patients, particularly data of borderline cases, Dr. Ackerman says. This is a diagnosis in which the stakes are extremely high, he says. On one hand, failing to recognize this disease could end in a tragic, premature death that co...Human stem cell treatment restores motor function in paralyzed rats
...euralstem, the company that manufactures the hSSCs used in the study. In this study, we succeeded at reconstructing the neural circuitry, which had not been done before. The researchers believe that the therapy may eventually be proven even more effective in human patients, who would be able to receive ...Survey shows asthma not controlled in majority of patients
...s to assess control, such as the ACT questionnaire used in the survey. ...... for zeroing in on effective settings for implants used to treat diseases, such as epilepsy, in which seizures occur only sporadically, as well as conditions, such as depression, in which symptoms can vary widely from day to day. "In the case of tremor, physicians can alter the setting until they see th...