Pathway links inflammation, angiogenesis and breast cancer
...and doctoral student Dung-Fang Lee, and colleagues works like this: TNFa activates IKK, which as a kinase works by attaching phosphate groups to other proteins. IKK phosphorylates tuberous sclerosis 1 (TSC1)...Reductive stress linked to heart disease
...trips of other proteins fold inside cells. When it works properly, the cell produces the correct amount of reduced glutathione, which is healthy for the body. Unfortunately, when the gene that makes alpha B-Crystallin is mutated in humans, the protein unfolds improperly into aggregrates, the hallmark of th...'Heroes of Chemistry' honored for medical, energy, environmental breakthroughs
...d chelation are life-long. A single dose of Exjade works throughout the entire day, removing excess iron --...rch until 2002, when he moved to Solvias, where he works now as a Project Leader in the Business Unit Contract Synthesis. He received his basic education as...In women, caffeine may protect memory
...r, France. While we have some ideas as to how this works biologically, we need to have a better understanding of how caffeine affects the brain before we can start promoting caffeine intake as a way to reduce cognitive decline. But the results are interesting caffeine use is already widespread and it has ...AASM to school-bound: Sleep is the right ingredient for academic success
...nd maintain a later bedtime, says Dr. Glaze. This works for the summer until the start of the school year. They then need to advance their bedtime to meet early school start times. It is difficult to advance your bedtime and, once a schedule has been established, it may take days or weeks to develop a n...Trials underway for 'essential' new TB vaccine
... under development by Dr McShane, known as MVA85A, works in tandem to the BCG, acting as a booster. It uses the 85A antigen, a protein found in all strains of TB, to boost the response of T cells already primed by the BCG vaccine. T cells are produced by the body's immune system to fight infection. This va...ESA's Earth Explorer gravity satellite on show
...gnificantly advance our knowledge of how the Earth works and provide insight into ocean circulation, sea-level change, climate change, volcanism and earthquakes. The spacecraft has been in Italy at Thales Alenia Space, the prime contractor for the development, integration and testing, for roughly nine mont...Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
...eceive it, says lead researcher Maria Aguilar, who works in the department of Neurology at the Mayo Clinic Scottsdale, Arizona, USA. While it is clear that both drugs can bring benefit, it is unclear at what point a person should start to take them. The threshold of benefit that would warrant anticoagu...Chemical in brain acts like a fuel gauge
.... If we dont know how an automobiles fuel system works to begin with, then how can we expect to fix one when it is not burning fuel appropriately" In his study, Khan injected insulin in a group of animals to drop their blood sugar levels. In another group, he injected norepinephrine directly into the p...Case study: cross-cultural bioethics training program helps fight African 'brain drain'
...phy professor from West Africa, a pediatrician who works with orphans, an advisor to the Cameroon military, two IRB coordinators, and a young staff member of an HIV vaccine-ethics group. In 2000, the Fogarty International Center of the National Institutes of Health (NIH) established the International Bi...Where is the most dangerous place to travel over the holiday?
... that can be done to prevent future deaths. CERS works to raise awareness of the problem of rural road fatalities, and advocate policy changes impacting road design and driver behavior. For instance, CERS advocates state adoption of primary seat belt laws, which allow law enforcement officers to pull pe...Damon Runyon renews its $2.25 million investment to support young clinical cancer investigators
...iam Harrington, Jr. and Dr. Glen Barber, Dr. Ramos works to clarify the precise mechanisms of interferon therapy in ATLL and identify the specific molecular markers associated with response and prognosis. Ultimately, his studies will provide a framework to develop tests that distinguish patients who will ...ACP supports improved access to information on relative strengths and weaknesses
...linicians and patients answer the question of what works best for each patient and for clinicians to partner with patients in an informed and shared decision-making process when considering alternative treatment options, a key element of the Patient-Centered Medical Home (PCMH). ACP recognizes the pot...Benefits of school-based fitness programs fade after summer
... action, more research is needed to determine what works to prevent or reduce childhood obesity, writes John Cawley, Ph.D., of Cornell University, Ithaca, N.Y., in an accompanying editorial. Specifically, the critical information that policymakers and educators lack is how to achieve the greatest reducti...Stanford researchers track human stem cells transplanted into rat brain
...ers can compare different techniques to learn what works best. The cells used in this study were similar to those that are part of a clinical trial for a childhood disorder called Batten's disease. Steinberg said he and others are interested in testing these or other stem cells as a way of treating a wid...Nonhormonal drug reduces hot flashes in men treated for prostate cancer
...t least 10 hot flashes a day. Because gabapentin works on the central nervous system, its function may be similar to some antidepressants that are prescribed to reduce hot flashes in women entering menopause, he says. "But we dont understand exactly how any of these drugs work to reduce hot flashes," say...VEGF Trap shows activity in patients with advanced ovarian cancer
...ly as a single agent in one of two dose levels. It works by blocking the development of new blood vessels to the tumor (angiogenesis) which stops tumor growth and the spread of cancer to other parts of the body (metastasis). It can also result in tumor shrinkage. VEGF Trap is generally well-tolerated altho...MRI detects cancers missed by mammography in breast cancer patients
...r, oncology resident Johnny Bernard Jr., M.D., who works with Dr. Vallow. This result mirrors findings of a 969-patient study reported in April 2007 in the New England Journal of Medicine ( http://content.nejm.org/ ) (NEJM) which concluded that MRI detected contralateral breast tumors in 3.1 percent of pat...Study: Directly observed HIV therapy for children is promising
...gorous cost-benefit analysis. We need to know what works in treating children in resource-poor settings so we know where to put limited HIV treatment dollars, he said....'Energy Up' demonstrates success as obesity intervention program for inner-city girls
...search gathered shows that the "Energy Up" program works and is successful in dealing with behavioral issues of adolescent girls. The program under review took place at an all girl, parochial high school in New York City during the school year of 2003-2004. Participants in "Energy Up" lost a significant a...